Gene Information

Name : guaA (Acry_0899)
Accession : YP_001234037.1
Strain : Acidiphilium cryptum JF-5
Genome accession: NC_009484
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 992345 - 993907 bp
Length : 1563 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTCCGACGCACCCTCCGCAGACCGCATCCTCATCCTCGATTTCGGCAGCCAGGTGACGCAGCTGATCGCGCGCCGCCT
GCGCGAGACCGGCGTCTATTGCGAAATCTGGCCATTCGACGCCGATCCGGCGCGCATGGCGGCTTTTGCGCCGAAGGGCA
TCATCCTTTCCGGCGGCCCGGCGAGCGTGATCGAGGAGGTCGCGCCGAAGCCCCCGGCCGACGTGTTCGGCGCCGGCGTG
CCGGTGCTCGGCATCTGCTACGGCGAGCAGGCGATCTGCGATGCGCTGGGCGGCGCGGTGGAAGGGTCGGACCATCGCGA
GTTCGGCCGCGCCTTCATCGACGTCACCGCGGACTGCGCGTTGTTCGAGGGCGTCTGGGCCAGGGGCCAGCGCGCCCAGG
TCTGGATGAGCCATGGCGACCGGGTGACCGCGCTGCCGCCCGGCTTCCGCGCGGTGGCGGTGAGCGAAGGCGCGCCCTTC
GCCGCCATCGCCGACGATGCGCGGCGCATCTACGGCGTGCAGTTCCATCCCGAGGTCGTCCACACGCCGGACGGCGCCCG
CCTGCTCGCGAATTTCGCGCACAAGGTCTGCGGCCTTGCGGGCGGCTGGACGATGGCGAATTTCCGCGAGACCGCGCGCG
ATGCGATCCGCGCCCAGGTCGGCACCGGGCGGGTGATCTGCGGCCTGTCCGGCGGCGTCGATTCCTCGGTCGCGGCGGCC
CTGATCCACGAGGCGATCGGCGACCAGCTCGTCTGCATCTTCGTCGATCACGGCCTGCTCCGCGCCGGCGAGGCGGACGA
GGTCGTGCGCGTCTTCCGCGACCGCTTCAACATACGACTGGTGCATCGAGACGCATCGGACCTGTTCTTCGCGGCTCTCG
AGGGCGTCACCGATCCGGAGGTGAAGCGCAAGACGATCGGCCGCCTGTTCATCGAGGTGTTCGAGGAAGAGGCGAAGAAT
CTCGGCGGCGCCGATTTCCTCGCCCAGGGCACGCTGTATCCGGACGTGATCGAAAGCGTCTCCGCTCGCGGCGGGCCCAG
CGCCGTCATCAAGTCGCACCACAATGTCGGCGGCCTGCCCGACCGGATGCGGATGAAACTGGTCGAGCCGCTGCGCGAAC
TCTTCAAGGACGAGGTGCGCGAACTCGGCCGCGAGCTGGGGCTGCCCGAGACCATCGTCGGCCGCCATCCCTTCCCCGGC
CCCGGCCTTGCCATCCGCATCCCCGGCCCGGTCGACCGCGAGAAGGTCCGCATCCTGCAGAAGGCAGATGCGATCTATCT
CGAGGAAATCCGCAATGCCGGCCTGTATGACGCGATCTGGCAGGCCTTCGTGGCCCTGCTACCGGTGCGCAGCGTCGGCG
TGATGGGCGACGGCCGCACCTACGACTTCGCCTGCGCCCTGCGCGCCGTCACCAGCACTGACGGAATGACAGCCGACGTC
TACCCGTTTGACATGAGCTTCCTGACGCGTGTCGCCGGGCGGATCGTCAACGAAGTGCGCGGCATCAACCGCGTCACCTA
TGACATCACCAGCAAGCCGCCCGGCACCATAGAGTGGGAATAG

Protein sequence :
MSDAPSADRILILDFGSQVTQLIARRLRETGVYCEIWPFDADPARMAAFAPKGIILSGGPASVIEEVAPKPPADVFGAGV
PVLGICYGEQAICDALGGAVEGSDHREFGRAFIDVTADCALFEGVWARGQRAQVWMSHGDRVTALPPGFRAVAVSEGAPF
AAIADDARRIYGVQFHPEVVHTPDGARLLANFAHKVCGLAGGWTMANFRETARDAIRAQVGTGRVICGLSGGVDSSVAAA
LIHEAIGDQLVCIFVDHGLLRAGEADEVVRVFRDRFNIRLVHRDASDLFFAALEGVTDPEVKRKTIGRLFIEVFEEEAKN
LGGADFLAQGTLYPDVIESVSARGGPSAVIKSHHNVGGLPDRMRMKLVEPLRELFKDEVRELGRELGLPETIVGRHPFPG
PGLAIRIPGPVDREKVRILQKADAIYLEEIRNAGLYDAIWQAFVALLPVRSVGVMGDGRTYDFACALRAVTSTDGMTADV
YPFDMSFLTRVAGRIVNEVRGINRVTYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-128 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-128 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-128 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-115 52