Gene Information

Name : guaA (PTH_2551)
Accession : YP_001213101.1
Strain : Pelotomaculum thermopropionicum SI
Genome accession: NC_009454
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2655660 - 2657201 bp
Length : 1542 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACTTTGCCTGAGCAGGAAATGGTAATAGTCCTGGATTTCGGCGGCCAGTACAGCCACCTGATTGCCCGCCGCGTCCG
GGAACTGAAAGTATTCTGTGAGATGCTGCCTTTCTCGACGCCGGTCGAGGAGATAAAAAAGAAAGGGCCCAGGGGCATTA
TCTTTTCGGGCGGACCTTCCAGCGTGTATCAGAAAAATGCGCCGTTCTGCGACCCGGCCGTTTATGATCTGGGCGTGCCC
ATTCTGGGCATCTGCTACGGGATGCAGTTGATGGCTTACCAGCTTGGGGGCCGTGTGTCTCCGGCCGGCCGCCGGGAGTA
CGGCCGGACCGGCCTGAACGTTCTTGACAGGGGCGGGCTTTTTTCCGGCCTTGAGCCCTTCGAGCAGTGCTGGATGAGCC
ACGGCGACCTGGTGGAGTTGCCGCCTCCCGGCTTCAACGTTACCGCGCGCACGGACAAGGCCCCGGTGGCGGCTATGGCC
GACCCGGCCAGAAAGCTTTATGCCGTCCAGTTTCACCCTGAAGTGGTGCACACCCCGAAGGGCCAGGACATACTGAGGAC
CTTTCTTTACGGCATCTGCGGCTGCAGGGGGCTGTGGACGATGGGCTCTTTCCTGGAGCGGGCCGTGGCCGAGGTGCAGG
AGCAGGTGGGAAGCGGAAGGGCGCTCTGCGCTTTGAGCGGCGGGGTGGATTCCTCCGTGGCGGCGGTGCTGGTGCACCGG
GCGGTGGGGGACCGTCTCACCTGCGTTTTTGTAAACCACGGACTTTTGCGCAAGGGCGAGGCGGAGCAGGTGCAGAAGAC
CTTCAAGGAAAAGTTCAAGATGAACCTGATCTACGTGGACGCGCGCCGGCGGTTCCTGTCCAGGCTGGCCGGGGTGACCG
ACCCGGAAATGAAGAGGAAGATTATCGGCGAGGAGTTTATCCGCGTTTTTGAAGACCAGGCGGCCGCCTTAGGCCAGGTT
GACTTTCTGGTTCAGGGGACGCTTTACCCGGACGTGGTGGAAAGCGGCACGGCCACGGCGGCGGTAATCAAGAGCCACCA
CAACGTGGGCTGTTTGCCGGGGGACATGCGCTTCGGCCTGGTGGAGCCCCTGCGCTGGCTGTTTAAGGACGAGGTGAGGG
AGCTTGGCGAGGAAATGGGCCTGCCGGAAGAGGTGATCTGGCGCCAGCCTTTCCCCGGCCCGGGTCTGGCGGTGCGCATC
CTGGGCGAGGTGACCGAGCACAAGCTGGCCATCCTGCAGGAGGCGGACGCCATCGTGGAGGAGGAAATCCGGAAGGCCGG
CCTTTACCGGCAGATCTGGCAGTCTTTTGCCGTGTTGCCCGACATAAAAAGCGTGGGCGTGATGGGGGACGAGCGGACTT
ATTCGTACACCGTGGCCGTCCGGGCGGTGCACAGCCGCGACGCCATGACCGCCGACTGGGTGCGCCTGCCCTACGAGGTG
CTGGAGGCCATCTCCTCCCGCATTGTCAGCGAGATCAAGGAAGTGAACCGGGTGGTCTACGACATTACTTCCAAGCCCCC
GGCGACAATTGAGTGGGAATAG

Protein sequence :
MTLPEQEMVIVLDFGGQYSHLIARRVRELKVFCEMLPFSTPVEEIKKKGPRGIIFSGGPSSVYQKNAPFCDPAVYDLGVP
ILGICYGMQLMAYQLGGRVSPAGRREYGRTGLNVLDRGGLFSGLEPFEQCWMSHGDLVELPPPGFNVTARTDKAPVAAMA
DPARKLYAVQFHPEVVHTPKGQDILRTFLYGICGCRGLWTMGSFLERAVAEVQEQVGSGRALCALSGGVDSSVAAVLVHR
AVGDRLTCVFVNHGLLRKGEAEQVQKTFKEKFKMNLIYVDARRRFLSRLAGVTDPEMKRKIIGEEFIRVFEDQAAALGQV
DFLVQGTLYPDVVESGTATAAVIKSHHNVGCLPGDMRFGLVEPLRWLFKDEVRELGEEMGLPEEVIWRQPFPGPGLAVRI
LGEVTEHKLAILQEADAIVEEEIRKAGLYRQIWQSFAVLPDIKSVGVMGDERTYSYTVAVRAVHSRDAMTADWVRLPYEV
LEAISSRIVSEIKEVNRVVYDITSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-152 59
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 7e-152 58
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 6e-152 58
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-141 57