Gene Information

Name : guaA (DNO_0380)
Accession : YP_001209299.1
Strain : Dichelobacter nodosus VCS1703A
Genome accession: NC_009446
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 417628 - 419181 bp
Length : 1554 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCTTCATTCTAATCTTCATAACGATAAAATTTTAATTCTGGACTTTGGCTCGCAATTTACGCAATTAATTGCGCGCCG
TGTGCGCGAGGCGGGCGTTTATAGCGAAATCTACGCTTACGATGTGGATCCGCAAATGATCCGCGCTTTTGCGCCCAAAG
GCATCATTCTTTCCGGCAGTCCTAATAGTACGCTCGAAAGCGATGCGCCAACCATTCCTGAAATTGTTTGGCAATTGGAT
TGCCCGATTTTAGGCGTTTGCTACGGCATGCAGGCGATGATTAAACATTGGGGCGGTCAAGTTACGCATACAAATCAACA
AGAATTTGGTTATGCCGCGCTGGATTTTCAAGCGGATCACGCCTTTTTTGCCGGATTGGATATGCGCGATGTTTGGATGA
GCCACGGCGACCACGTCAGCCAATTGCCGGCAGAATTTGTTGCGATTGCGTCTTCAAATAATGCGCCGATTGCTGCTTGC
GCGCATCAATCAAAACCGTGGTACGGCGTGCAATTTCACCCAGAAGTCACGCATACACCAAACGGCGCGGCATTAATCGC
ACAATTCGTGCGCAAAATATGCGGTTGTTCAGCTGATTGGACAACCGAGCATTTTATTACCGAAAAACGGCGCGAAATTG
CCGAAAAAGTAGGCACCGAAAAAGTTATTTTGGGATTATCGGGCGGCGTGGATTCTTCCGTGGTTGCGGCGTTATTGCAC
GAAGTCATCGGCGCGCAATTGACATGTGTTTTTGTGGATACGGGTTTATTGCGTTTGCATGAAGGCGATGAAGTGATGGC
GGTTTTTGCGCAAAATATGGGCGTTAACGTGATTCGCGTTAATGCGGCTGATCGCTTTTTTGCAGCATTAAAAGGGGTGA
CCGATCCCGAGGAAAAACGCAAAACTATCGGGCGTTTGTTTATTGAAATTTTTGATGAAGAAGCGGCAAAAATTAAGGAC
GCTAAATGGTTGGCGCAGGGCACGATTTATCCTGATGTGATTGAATCGGCTGGTAGTAAAACGGGCAAAGCGCAAGTGAT
TAAATCGCATCACAATGTGGGCGGTTTGCCTGAAAAGATGAATTTATCGCTTTTGGAACCGTTGCGCATGTTGTTTAAAG
ATGAAGTGCGGCAATTGGGGCTGGCTTTGAGCTTGCCAAAAACGATGATTTATCGTCACCCTTTTCCGGGGCCAGGTTTG
GGCGTGCGCATTTTGGGAGAAGTGAAGGCGGAATATGCCGATTTGCTGCGGCAAGCCGATGCGATTTTTATTCAAGCGTT
GCGCGAATATGATTTATATGATGCTGTGAGCCAAGCGTTTGCTGTTTTTTTACCGATTCGTTCGGTGGGCGTGATGGGCG
ACGGGCGGCGTTATGATTTTGTAGTGGCGTTGCGCGCGGTGGAAACAATTGATTTTATGACGGCGCGGTGGGCAAAATTG
CCTTATGATTTTTTAGATGAAGTTTCGCGGCGGATTATTAATCATGTTTCGGGCATTTCGCGCGTGGTTTACGATGTGAG
TAGTAAACCGCCGGCAACGATTGAGTGGGAATAG

Protein sequence :
MLHSNLHNDKILILDFGSQFTQLIARRVREAGVYSEIYAYDVDPQMIRAFAPKGIILSGSPNSTLESDAPTIPEIVWQLD
CPILGVCYGMQAMIKHWGGQVTHTNQQEFGYAALDFQADHAFFAGLDMRDVWMSHGDHVSQLPAEFVAIASSNNAPIAAC
AHQSKPWYGVQFHPEVTHTPNGAALIAQFVRKICGCSADWTTEHFITEKRREIAEKVGTEKVILGLSGGVDSSVVAALLH
EVIGAQLTCVFVDTGLLRLHEGDEVMAVFAQNMGVNVIRVNAADRFFAALKGVTDPEEKRKTIGRLFIEIFDEEAAKIKD
AKWLAQGTIYPDVIESAGSKTGKAQVIKSHHNVGGLPEKMNLSLLEPLRMLFKDEVRQLGLALSLPKTMIYRHPFPGPGL
GVRILGEVKAEYADLLRQADAIFIQALREYDLYDAVSQAFAVFLPIRSVGVMGDGRRYDFVVALRAVETIDFMTARWAKL
PYDFLDEVSRRIINHVSGISRVVYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 7e-124 52
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 9e-124 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 8e-124 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-105 46