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Name : ureC (Msed_0887) Accession : YP_001190983.1 Strain : Metallosphaera sedula DSM 5348 Genome accession: NC_009440 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 820729 - 822396 bp Length : 1668 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : TTGAAAATTTCAAGGGAGAGATACGCAGAACTATACGGACCAACAGAGGGGGATAAGATCAGACTGGGTGACACAAACCT AGTTATCACGGTCGAGAAGGACATGATTAGAAAGGGTGATGAACTTGTGTTTGGTGCAGGCAAATCCGCCCGTGACGGAT TGGGTCTTCTTCCGACGGTGAAGGAAGAGGAGTCCATGGATCTCGTTATCACAAATGTGGTGATAATGGACCCTTTACTT GGAATAGTTAAAGCCGACATAGGAATAAAGGACGGAGTCATCGTGGGGATAGGTCATGGTGGTAACCCATTTACCATGGA TGGAGTTGACTTCGTGCTGGGACCGTCGACCGAGGTAATTTCTGGAGAGGGGTTAATAGCCACTCCAGGTTTCATAGACA CTCACGTTCACTGGGTTGCCCCACAGCAGGTATACGATGCGATCTCCGCAGGCTTCACGACCTTAATTGGCGGAGGTACC GGTCCGGCCGAGGGGACCAAGGCAACCACGGTCACCCCAGGATCTTGGAACTTGAGAGTGATATTTTCTGCCCTGGACCA GTATCCCGTAAACTTCGGTCTAACTGCGAAGGCGTCATCAACGTCAGTTAGCATGGAGCAAGTGCTGAACCAGGGCGCGT GTGGATTCAAGATTCATGAGGACTGGGGAGCCATGCCGAGGGTAATTGATGAAACCTTAACCTTGGCTGACCAGAGGGAC GTGCAGGTCACTATTCACACAGATACATCTAATGAGAGCGGATTCCTCGAGGACACCTTAAGCGCGATTGGCGGTAGGAC TATTCACGCCTATCACGTGGAAGGTGCGGGAGGAGGTCACGCTCCAGACATCATTAAAATTGCAGGAGAACCCAACATAC TTCCGTCCTCAACTAATCCCACTAAACCCTTCACAGTCCACACATATGAGGAACACCTGGAGATGCTCATGGCAGTTCAT CACCTGAACCCAAAGGTACCTGAGGACGTGTCCTATGCGGAATCCAGAATCAGGGCTGAAACCATGGCTGCCGAGGATTA CCTCCACGATCTTGGGGCAATAAGCATGATGTCTTCGGACTCGCAAGCCATGGGAAGGATTGGGGAGACAGGAATTAGGA CATTCCAGCTTGCTCATAAGATGAAGGAACTTAACCTGATCCCCATGCCTGACAATCAAAGGGTCCTGAGATATCTCGCA AAAATAACCATAAATCCTGCCATAACCCACGGTATATCAGAGTACGTAGGATCCCTGTCCCCTGGAAAGCTGGCAGATAT TGTTCTGTGGGACCCTAGGTTTTTCCCCGCGAAGCCCTACATGGTTATCAAGGGCGGAGCCATCTCATGGGCCCTAATGG GTGAAACCAACGCCTCTATTGCATATGCTCAGCCTGTGCTTTACAAACCCATGTTCGGATTTACAGCGCCGGTATCCCTG CTATTTTCCTCACTGGATGGGGTAAACGAAGCGGGGAAAAATGTCAAGAGGAGAGTGGTACCAGTAAGAAATACTAGGAC CATCTCGAAATCTCACATGAAACTTAACGATGCTACGCCTGAGATAGAGGTGGACCCTGACAAATATGAGGTTAAGGTCG ATGGGGTAGTCCCGAAGATCCCGCCTTCTAAGGAATTGCCTCTAACCAGATTATACTTCCTGTTTTAG Protein sequence : MKISRERYAELYGPTEGDKIRLGDTNLVITVEKDMIRKGDELVFGAGKSARDGLGLLPTVKEEESMDLVITNVVIMDPLL GIVKADIGIKDGVIVGIGHGGNPFTMDGVDFVLGPSTEVISGEGLIATPGFIDTHVHWVAPQQVYDAISAGFTTLIGGGT GPAEGTKATTVTPGSWNLRVIFSALDQYPVNFGLTAKASSTSVSMEQVLNQGACGFKIHEDWGAMPRVIDETLTLADQRD VQVTIHTDTSNESGFLEDTLSAIGGRTIHAYHVEGAGGGHAPDIIKIAGEPNILPSSTNPTKPFTVHTYEEHLEMLMAVH HLNPKVPEDVSYAESRIRAETMAAEDYLHDLGAISMMSSDSQAMGRIGETGIRTFQLAHKMKELNLIPMPDNQRVLRYLA KITINPAITHGISEYVGSLSPGKLADIVLWDPRFFPAKPYMVIKGGAISWALMGETNASIAYAQPVLYKPMFGFTAPVSL LFSSLDGVNEAGKNVKRRVVPVRNTRTISKSHMKLNDATPEIEVDPDKYEVKVDGVVPKIPPSKELPLTRLYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 3e-121 | 53 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 3e-121 | 53 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-111 | 51 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-111 | 51 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-111 | 51 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-111 | 51 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_001190983.1 | urease subunit alpha | VFG0270 | Protein | 2e-116 | 52 |
