Gene Information

Name : guaA (Ent638_2998)
Accession : YP_001177713.1
Strain : Enterobacter sp. 638
Genome accession: NC_009436
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 3259993 - 3261570 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACGGAAAACATTCATAAACATCGCATTCTTATCCTGGACTTCGGCTCCCAATACACGCAGCTTGTTGCTCGTCGCGT
GCGTGAACTTGGCGTTTATTGTGAACTGTGGGCATGGGATGTCACGGAAGCACAGATCCGTGAATTTAACCCAAGCGGCA
TTATTCTTTCTGGTGGTCCGGAAAGTACCACTGAAGACAACAGCCCACGCGCGCCGCAGTATGTATTTGAAGCAGGCGTT
CCTGTATTTGGCGTGTGTTACGGCATGCAGACGATGGCGATGCAGTTGGGCGGCCATGTTGAAGCCTCTAACGAGCGCGA
ATTTGGTTACGCGCAGGTCGAAGTGTTGACCGACAGCGCGCTGGTGCGTGGCATTGAAGATTCCCTGACCGCAGACGGTA
AACCGCTGCTGGACGTGTGGATGAGCCACGGCGATAAAGTGACAGCCATTCCGTCAGACTTCGTGACCGTTGCCAGCACC
GAAACCTGTCCGTTTGCCATTATGGCCAACGAAGAAAAACGCTTCTACGGCGTGCAGTTCCACCCGGAAGTGACCCATAC
CCGCCAGGGCATGCGCATGCTGGATCGTTTTGTTCGCGATATCTGCCAGTGCGAAGCCCTGTGGACACCAGCGAAAATCA
TCGACGACGCCATTGCGCGTATCCGCCAGCAGGTTGGCGACGATAAAGTGATCCTCGGTCTGTCCGGTGGCGTTGACTCC
TCCGTAACTGCCATGCTGCTGCACCGTGCTATCGGTAAAAATCTGACCTGTGTATTCGTCGATAATGGCCTGTTACGCCT
GAACGAAGCCGAGCAGGTGATGGATATGTTTGGTGACCACTTCGGCCTGAACATCGTTCACGTCGAAGGTGAAGAGCGTT
TCCTGACCGCACTGGCGGGCGAGAACGATCCGGAAGCAAAACGTAAAATTATCGGCCGCGTGTTTGTTGAAGTCTTCGAC
GAGCAAGCGCTGCGTCTGGAAGATGTGAAGTGGTTGGCACAGGGTACGATTTACCCTGATGTGATCGAGTCTGCTGCCTC
TGCTACCGGCAAGGCACACGTCATCAAATCTCACCACAACGTGGGCGGCCTGCCGAAAGAGATGAAGATGGGTCTGGTTG
AGCCGCTGCGTGAGCTGTTCAAAGACGAAGTGCGTAAGATTGGCCTTGAGCTGGGTCTTCCATACGACATGCTGTACCGT
CACCCGTTCCCGGGACCAGGTCTTGGCGTGCGTGTGCTGGGCGAAGTGAAGAAAGAGTACTGCGACCTGCTGCGTCGTGC
TGATGCTATCTTCATCGAAGAACTGCACAAAGCCGATCTGTACAATAAAGTGAGCCAGGCATTCACCGTGTTCCTGCCGG
TTCGTTCCGTCGGCGTGATGGGCGATGGCCGCAAATACGACTGGGTTGTCTCCCTGCGTGCGGTAGAAACCATCGACTTC
ATGACGGCACACTGGGCGCACCTGCCGTATGATTTCTTAGGCCGCGTGTCTAACCGCATCATCAACGAAGTGAACGGTAT
TTCCCGTGTCGTGTACGACATCAGCGGTAAACCGCCAGCGACGATTGAGTGGGAATGA

Protein sequence :
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGPESTTEDNSPRAPQYVFEAGV
PVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVLTDSALVRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVAST
ETCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLDRFVRDICQCEALWTPAKIIDDAIARIRQQVGDDKVILGLSGGVDS
SVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVEGEERFLTALAGENDPEAKRKIIGRVFVEVFD
EQALRLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLRELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-123 50
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-123 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-123 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-108 49