Gene Information

Name : guaA (YPDSF_2215)
Accession : YP_001163563.1
Strain : Yersinia pestis Pestoides F
Genome accession: NC_009381
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2503680 - 2505257 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAAAAAATATCCATAAGCATCGCATCCTTATTCTTGATTTCGGCTCGCAGTACACCCAATTATTGGCGCGTCGTGT
GCGTGAGATTGGTGTCTATTGTGAACTATGGGCATGGGATGTCACCGAAGCCCAAATCCGTGAATTTAATCCAAGTGGTA
TCATCCTCTCTGGTAGCCCTGAAAGTACGATAGAAAACGGTAGCCCGCGCGCACCAGACTATGTGTTTACGGCTGGTGTA
CCGGTGTTGGGTGTGTGCTATGGCATGCAGACCATGGCGATACAATTGGGCGGTAAAGTTGAGAGTTCAAATCAGCGTGA
ATTTGGTTATGCGCAAGTTGAAATTAAAGCTGACAGCGCGCTGATCCGTGATATCAAAGATGCCATCAATCCGGCAGGCG
AAGCCGTATTGGATGTTTGGATGAGTCACGGTGACAAAGTTGCGGAGATCCCTGCTGATTTTGTCACGGTTGCCAGCACG
GATACCTGTCCGTTTGCCATTATGGCTAACGAAGAAAAACGTTTTTATGGTGTCCAGTTCCATCCTGAAGTGACACACAC
CAAGCAAGGCCTGCGTTTGTTGGAGCGTTTCGTGCTGGGTATCTGTGGCTGCGAAGCGCTATGGACATCTGCCACCATTA
TCGAAGATGCAATTGTCCGTTTGCGTGAGCAAATCGGCGACGATCATGTGATCTTGGGGTTAAGTGGCGGTGTCGACTCT
TCAGTGACGGCCATGTTGTTGCACCGCGCTATCGGTAAACGCCTGACCTGTGTATTCGTGGATAACGGCCTATTACGCTT
AAACGAAGCAGATCAGGTCTTGGAAATGTTTGGCGATAAATTTGGCCTGAATATTGTCCATGTGGCGGCAGAGGATCGCT
TCCTTTCGGCACTGACGGGAGTGGACGAACCAGAAGCGAAACGTAAAATCATTGGCCGTGTCTTTGTCGAACTCTTCGAC
GAAGAAGCCTGTAAACAAGAGCAGGTGAAATGGTTGGCACAGGGTACGATTTACCCTGATGTGATCGAATCGGCTGCATC
AGCTACCGGTAAAGCGCATGTGATTAAATCTCACCACAATGTGGGCGGTTTGCCAAAAGAGATGAAGCTGGGCCTGGTTG
AGCCGCTGAAAGAGCTGTTTAAAGATGAAGTGCGCAAGATTGGTCTGGAGCTTGGCTTGCCATACGACATGCTGTACCGC
CATCCTTTCCCAGGGCCGGGCTTAGGTGTGCGCGTATTGGGCGAAGTGAAGAAAGAGTATTGCGATTTGCTGCGCCGTGC
TGACGCTATCTTTATTGAAGAGCTGCACAAAGCTGATTTGTACAATAAAGTTAGCCAGGCTTTCACTGTCTTCCTGCCAG
TACGTTCAGTCGGTGTGATGGGTGATGGCCGTAAATATGATTGGGTTGTCTCTCTGCGTGCGGTAGAGACGGTTGATTTC
ATGACTGCACATTGGGCACATCTGCCATACGACTTCCTTGGCCGCGTTTCAAACCGCATCATTAATGAAGTCAATGGTAT
CTCGCGCGTAGTTTATGATATCAGCGGCAAGCCACCTGCAACGATTGAGTGGGAATGA

Protein sequence :
MTKNIHKHRILILDFGSQYTQLLARRVREIGVYCELWAWDVTEAQIREFNPSGIILSGSPESTIENGSPRAPDYVFTAGV
PVLGVCYGMQTMAIQLGGKVESSNQREFGYAQVEIKADSALIRDIKDAINPAGEAVLDVWMSHGDKVAEIPADFVTVAST
DTCPFAIMANEEKRFYGVQFHPEVTHTKQGLRLLERFVLGICGCEALWTSATIIEDAIVRLREQIGDDHVILGLSGGVDS
SVTAMLLHRAIGKRLTCVFVDNGLLRLNEADQVLEMFGDKFGLNIVHVAAEDRFLSALTGVDEPEAKRKIIGRVFVELFD
EEACKQEQVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKLGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETVDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 6e-127 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-127 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 8e-127 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-110 47