Gene Information

Name : thyA (Pnuc_0381)
Accession : YP_001155165.1
Strain : Polynucleobacter necessarius QLW-P1DMWA-1
Genome accession: NC_009379
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 373325 - 374119 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGCGCCAATATCACAATTTAATGAAAGAAGTCCTAGCCAAGGGCGTACAAAAGTCCGATAGAACTGGGACCGGCACGAT
CTCGGTATTTGGGCACCAGATGCGTTTTAATTTGGCCGACGGCTTTCCAATGGTCACCACCAAGAAGCTCCACATGAAGT
CCATTGTTTATGAATTACTCTGGTTTCTCAAAGGCAGTACAGATAATAATTGGCTTAAAGAGCGTGGCGTATCCATCTGG
AATGAATGGGCAGCTCCTGACGGCGATTTAGGCCCTATATATGGCTATCAATGGCGTTCTTGGCCTGCGCCTAATGGTCA
GCACATTGATCAGATCTCTGAAGTGGTGGAGACCATCAAAAAGAATCCTGACTCACGTCGCATCATTGTTTCAGCTTGGA
ATGTGGCAGATATCCCGCGTATGGCTTTAGCGCCTTGCCACGCCTTCTTTCAGTTTTATGTTGCCGACGGAAAGTTATCC
TGCCAGCTATATCAGCGAAGTGCTGATATTTTCTTGGGCGTCCCATTTAATATCGCTAGCTACGCTTTATTGACCCATAT
GGTGGCGCAGCAATGTAATTTAGAAGTGGGTGACTTTATTTGGACTGGTGGCGATTGTCATTTATATAGCAACCATTTAG
AGCAAGTTGACCTCCAATTATCGAGAGATTTTTTACCCCTGCCTAAACTCAATATTCTGCGTAAACCAGATTCACTCTTC
GATTATGAATTTGAAGACTTTGAAATTGTTGGCTACGAATCCCATCCCCACATTAAAGCTCCAGTAGCTATTTAA

Protein sequence :
MRQYHNLMKEVLAKGVQKSDRTGTGTISVFGHQMRFNLADGFPMVTTKKLHMKSIVYELLWFLKGSTDNNWLKERGVSIW
NEWAAPDGDLGPIYGYQWRSWPAPNGQHIDQISEVVETIKKNPDSRRIIVSAWNVADIPRMALAPCHAFFQFYVADGKLS
CQLYQRSADIFLGVPFNIASYALLTHMVAQQCNLEVGDFIWTGGDCHLYSNHLEQVDLQLSRDFLPLPKLNILRKPDSLF
DYEFEDFEIVGYESHPHIKAPVAI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 7e-89 66