Gene Information

Name : guaA (Pars_1772)
Accession : YP_001153975.1
Strain : Pyrobaculum arsenaticum DSM 13514
Genome accession: NC_009376
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1592247 - 1593764 bp
Length : 1518 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGAGAAGATCCTTGTCGTAAATCTAGGCGGACAATATGCTCACCTAATAGCGAGAAGAATTAGAGAAATCGGGGCATA
CGCGGAGATTGCTTCATACGACTCCGTTCTCGAAGTGGCGAAAAGCGATGAGGTAAAAGCCATAGTTCTCTCGGGAGGCC
CGGCTTCGGTGTACGAACCAAACTCGCCAGATCTGCCGGTGGACCTCCTTTACCTCGGAAAACCTGTGCTTGGCATATGC
TTCGGACACCAGTGGATAGCCAAAAAACTAGGAGGAGTCGTAGAACGCGGCAAGGGCGAGTACGGAAAGACTATGGTTAG
AATCTTGTCTAGCGACCCCCTCTTTGAGGGGTGGGAAGCAGAGGAGGTGGTTTGGATGAGCCACAGCGACTACGTAAAGG
AGGTCCCAAGCGGCTTCCAAGTCTTGGCAGTAAGCGAAAACGGCTACGTTGCGGCTATGAGGAGCGGCCACATCTACGGA
GTTCAGTTCCACCCTGAGGTTAGACACACGGTAAAGGGGATTCGACTTTTAGAAAACTTTGTGAGAAAGGTTGCCGGCAT
CAAATCGGTTTGGGTGCCTGAAGAGCAAGTTGGTAAAATAGTGGAAGAGATAAAAGCAATGGTCAAGGAAGGCATTGTAG
TCGTAGGCGTTAGCGGTGGCGTGGACAGCACCGTCACCGCGGTTCTCCTCCACATGGCGTTAGGGAGCCGCGTCAAGGCA
GTCTTCATCGACCACGGCTTATTCAGAGAGGGGGAGCCCGAGAAGGCTGTACAGCTCCTTAGATCAGTAGGAATAGACGT
GTTGTATATCGACGCGAGAGAGCGTTTCCTTAAAAAGCTTGATGGGGTGTCCGACTGCGAAGAGAAGAGAAGAATTGTCG
GAGAGACCTTCGCCGAGGTGTTCACAGAAGTGGTGGCTGGGATACCTAATGCCAAATACCTCGCACAAGGTACGCTGTAT
CCAGACGTCATAGAAAGCGGAGCAGTAAAGGGCGCAGATAGAATAAAAAGCCACCACAACGTCGGAGGGATCCCACCCTG
GTTTACCCTAGAACTAATCGAACCGCTTAGAGACTTTTACAAAGACGAGGTAAGAAGAATAGCAAAGTCCCTTGGTTTGC
CAGATGAGGTAGTTTACCGACATCCCTTTCCCGGTCCAGGTCTTGCAGTAAGGATAATAGGGCCCTTTACCCTTGAGAAG
CTTGAAATAGTGAGGAGAGCTACAAAGATTGTAGAAGAAGAGCTGGAAAGGGCGGGTCTTCTGAGAAAGGTATGGCAAGC
CTTCGCCACAGTGGGTGAGGATAAATGGGTGGGAGTAAAGGGAGATAGACGCGCCGAGGGCTACATAGTTACAGTTAGGG
TTGTGGAAAGCGAAGATGCTATGACAGCCGACTGGGCCAAGATCCCACACGACGTCTTGGACAAGATCTCCTCGCGTATT
GCATCAGAAATTCCACACGTAACAATGGTTACATATGCAATTACCTCCAAACCCCCCTCAACAATTGAGCCGTGTTAA

Protein sequence :
MEKILVVNLGGQYAHLIARRIREIGAYAEIASYDSVLEVAKSDEVKAIVLSGGPASVYEPNSPDLPVDLLYLGKPVLGIC
FGHQWIAKKLGGVVERGKGEYGKTMVRILSSDPLFEGWEAEEVVWMSHSDYVKEVPSGFQVLAVSENGYVAAMRSGHIYG
VQFHPEVRHTVKGIRLLENFVRKVAGIKSVWVPEEQVGKIVEEIKAMVKEGIVVVGVSGGVDSTVTAVLLHMALGSRVKA
VFIDHGLFREGEPEKAVQLLRSVGIDVLYIDARERFLKKLDGVSDCEEKRRIVGETFAEVFTEVVAGIPNAKYLAQGTLY
PDVIESGAVKGADRIKSHHNVGGIPPWFTLELIEPLRDFYKDEVRRIAKSLGLPDEVVYRHPFPGPGLAVRIIGPFTLEK
LEIVRRATKIVEEELERAGLLRKVWQAFATVGEDKWVGVKGDRRAEGYIVTVRVVESEDAMTADWAKIPHDVLDKISSRI
ASEIPHVTMVTYAITSKPPSTIEPC

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 7e-104 49
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-104 49
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-104 49
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-97 45