Gene Information

Name : zntA (ASA_0629)
Accession : YP_001140540.1
Strain : Aeromonas salmonicida A449
Genome accession: NC_009348
Putative virulence/resistance : Resistance
Product : zinc/cadmium/mercury/lead-transporting ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 643833 - 646256 bp
Length : 2424 bp
Strand : -
Note : P-type ATPase involved in the export of lead, cadmium, zinc and mercury

DNA sequence :
ATGAGCAAATCCTGCTGCAGCCATCAACACACAGCGGCCACCGGCAAGGCCGTCACCAGCCAAGTCGAACATCAACACGA
CAGCCACTGCTGTGACAATGTCGAACAGGTCAGTTGCTGCGCCAGCAAGGCACCCCATGATCATCAGGATCAGGGGGTGA
GTGAATCACCGGGGGATGAAGAGCCCCCCAGAGGAAGTTGTCAAAGCCAGGGCTGCTGCAGCCCGCAGCCGCCTCATGAC
CATGACCATGACCATGACCATCATGAGCATGATCACCATGAGCAAACCACCGACACCGCCGAGCCGTTAGTCGCGCCGGA
GCAGGACAGCCGCCGCCACAGCTGGCAGGTGCTGGGGATGGATTGCCCCAGCTGCGCCCGCAAGATAGAGACCGCCGTCA
GCCGGGTGGCGGGCGTGCAGCAGGCCCGGGTGCTGTTTGCCACCGAGAAGCTGGTGGTGGATCTCGCCCCCGGCCTCTCC
CCCGACCCCGTCACCGCCGCCGTGCTGGCCGCGGGTTTCCGGCTCAAAGGCGCAACTCAGCCCGGGGACGACAACGCCAG
GCGCCGCAGCCCGCAGATGGCCCTGCTCGCCAAGTATTGGCAGCCCCTGTCGCTGGCCGGCCTGATGCTGTTGGCTGCCC
TGCTGCCGAAAGAGTTCGGCCAGCCGCTGTTTACCCTGGCCACCCTCTGGGGCCTGTGGCCCATCTCCCGCAAAGCCTGG
GCCCTGACCAGGAGCGGCTCCCCCTTCGCCATCGAGACCCTGATGACGGTGGCGGCGCTGGGCGCCCTCTTCCTAGGTGA
AACCGCCGAGGCGGCCATGGTGCTGCTGCTGTTCATGCTGGGGGAGCATCTGGAGGCCTACGCCGCCGGCCGTGCTCGCG
CCGGCGTCACCGCCCTGATGGCGCTGGTGCCCGACAAGGCACTGCGGATCCGCACCAGGGTTGACGGTGACGTTCGGGAA
GAGGTGGCGGCCGACCAGCTGCGTCCCGGCGACATCATAGAGATCGCCCCGGGCGCCCGCCTGCCGGCAGATGCCCGCTT
GCTCGACGCCCTTGGGGCGTTTGACGAGAGTGCCCTGACCGGTGAGTCCATTCCGGTGGAACGTCGCCAGGGTGACAAGG
TGCCCGCCGGCAGTCTGGCGGCAGATCGGGTGCTGCGCCTCGAGGTGGTGTCCGAGCCCGGCAACAACGCCATCGACCGC
ATACTGCACCTGATCGAGGAAGCCGAGACCCAGCGCGCCCCCATAGAGCGCTTCATCGACCGCTTCAGCCGCTGGTATAC
CCCTGCCATGATGCTGGTTGCCCTGCTGGTGGTGATAGTGCCACCGCTGGCCTTTGGCCAGAGCTGGGACGAGTGGGTCT
ATCGCGGACTGGCGCTGCTGCTCATCGGCTGCCCCTGCGCCCTGGTGATCTCCACCCCGGCGGCTGTCACCTCCGCCCTG
GCGGCGGCAACCCGCCAGGAGGCCCTGATCAAGGGCGGTGCCGCGCTGGAGCGACTGGCCCATATAGACACAGTCGCCTT
TGACAAGACAGGCACCCTGACCCTGGGCAAGCCGCAACTGACCGAACTTGTCAGCCTCAATGACCAACCGGAGGACGAAC
TGCTGGCACTGGCCGCCGCCATAGAGCAAGGCTCCCATCATCCTCTGGCCCGCGCCGTGGTGGCCGCCGCCCGTGAGCAG
GGGCTGACTCTGGCCGCAGCCCAGGATCTGCGCGCCCTGCCAGGCATGGGGGTGGAAGGACGCGTCGACGGCACCCTCTG
GCAACTGCTGGCACCGAGCCGGATTGACTCGCTGAGCAATGCCCTCAACGCACAAATAGCCACCCTTGAGCAGCAGGGCA
AGACGGTGGTCGTGCTCGGCCAGCCGGGCGCAGCGCCGGCGGCCCTGTTGGCCCTGCGGGACCAGATCCGGCCCGAAGCG
GCAGCGGCCCTGGCGGAGCTCAAGGGGCTGGGACTGCGCAGCATTATGCTGACCGGTGACAACCCCCGCGCCGCCGAGGC
GATTGCCAACGAGCTCGGCATGGGCTGGCGCGCCAGCCTGCTGCCGGAAGACAAGGTGGAAGAGATCGCCAAGCTGGCCG
CCAGCCAGAAGGTCGCCATGATAGGGGATGGCATCAACGACGCCCCCGCCATGAAGCGGGCCAACATTGGCATCGCCATG
GGTGGCGGCACAGACGTGGCGCTGGAGACGGCCGATGCCGCCCTGACCCACAACCAGCTCGGTGGCATCGCCGCCATGAT
CCGCCTGTCGCGGGCGGCACTGGCCAACATCCACCAGAACATAGCGCTGGCGCTGGGACTCAAGGCCATCTTCCTGGTCA
CCAGTCTGCTCGGCATCACGGGCCTGTGGATTGCCGTGCTGGCGGATACCGGAGCCACCGCCCTGGTGACGGCCAACGCC
CTGCGTCTGCTGCGCAAGCGCTGA

Protein sequence :
MSKSCCSHQHTAATGKAVTSQVEHQHDSHCCDNVEQVSCCASKAPHDHQDQGVSESPGDEEPPRGSCQSQGCCSPQPPHD
HDHDHDHHEHDHHEQTTDTAEPLVAPEQDSRRHSWQVLGMDCPSCARKIETAVSRVAGVQQARVLFATEKLVVDLAPGLS
PDPVTAAVLAAGFRLKGATQPGDDNARRRSPQMALLAKYWQPLSLAGLMLLAALLPKEFGQPLFTLATLWGLWPISRKAW
ALTRSGSPFAIETLMTVAALGALFLGETAEAAMVLLLFMLGEHLEAYAAGRARAGVTALMALVPDKALRIRTRVDGDVRE
EVAADQLRPGDIIEIAPGARLPADARLLDALGAFDESALTGESIPVERRQGDKVPAGSLAADRVLRLEVVSEPGNNAIDR
ILHLIEEAETQRAPIERFIDRFSRWYTPAMMLVALLVVIVPPLAFGQSWDEWVYRGLALLLIGCPCALVISTPAAVTSAL
AAATRQEALIKGGAALERLAHIDTVAFDKTGTLTLGKPQLTELVSLNDQPEDELLALAAAIEQGSHHPLARAVVAAAREQ
GLTLAAAQDLRALPGMGVEGRVDGTLWQLLAPSRIDSLSNALNAQIATLEQQGKTVVVLGQPGAAPAALLALRDQIRPEA
AAALAELKGLGLRSIMLTGDNPRAAEAIANELGMGWRASLLPEDKVEEIAKLAASQKVAMIGDGINDAPAMKRANIGIAM
GGGTDVALETADAALTHNQLGGIAAMIRLSRAALANIHQNIALALGLKAIFLVTSLLGITGLWIAVLADTGATALVTANA
LRLLRKR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 4e-81 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
zntA YP_001140540.1 zinc/cadmium/mercury/lead-transporting ATPase BAC0461 Protein 5e-153 58
zntA YP_001140540.1 zinc/cadmium/mercury/lead-transporting ATPase BAC0298 Protein 2e-83 43