Gene Information

Name : guaA (cgR_0726)
Accession : YP_001137599.1
Strain : Corynebacterium glutamicum R
Genome accession: NC_009342
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 785908 - 787479 bp
Length : 1572 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGAGCCTTCAGACAAATCATCGCCCAGTACTCGTCGTTGACTTCGGCGCACAGTACGCGCAGCTGATCGCACGTCGTGT
GCGTGAGGCCGGCATCTACTCCGAAGTCATCCCGCACACCGCCACCGCAGACGATGTGCGCGCTAAAAATGCAGCAGCCC
TCGTCCTTTCCGGTGGTCCATCCTCCGTGTACGCCGAGGGAGCACCATCCCTTGACGCTGAGATCTTAGATCTCGGATTG
CCAGTATTTGGCATTTGCTACGGCTTCCAAGCCATGACCCACGCGCTTGGTGGCACCGTTGCCAACACCGGTAAGCGCGA
ATACGGACGTACCGACATCAACGTTGCCGGTGGCGTCCTCCACGAAGGCCTCGAAGCCTGCCACAAGGTGTGGATGAGCC
ACGGCGACGCCGTCTCTGAAGCCCCAGAAGGTTTCGTAGTCACCGCGTCCTCCGAAGGTGCGCCTGTCGCAGCTTTCGAA
AACAAGGAACGCAAAATGGCTGGCGTGCAGTACCACCCAGAGGTATTGCACTCACCACACGGCCAGGCAGTTCTGACCCG
CTTCCTCACTGAGATCGCAGGTCTAGAGCAGAACTGGACCGCAGCAAACATCGCTGAAGAACTCATCGAGAAGGTCCGCG
AGCAGATCGGCGAAGATGGCCGCGCTATTTGTGGCCTTTCCGGTGGTGTGGACTCCGCAGTCGCAGGTGCACTGGTTCAG
CGCGCTATTGGCGACCGTTTGACCTGTGTCTTTGTTGACCACGGTCTGCTTCGTGCCGGTGAGCGCGAGCAGGTTGAAAA
GGACTTCGTCGCAGCAACCGGCGCCAAGCTGGTTACCGTTGATGAGCGCCAGGCATTCCTATCCAAGCTGGCCGGAGTTA
CCGAACCAGAAGCAAAGCGCAAGGCTATCGGCGCTGAGTTCATCCGCTCCTTCGAGCGCGCAGTTGCCGGTGTGTTGGAA
GAAGCTCCAGAAGGTTCCACCGTGGACTTCCTGGTTCAGGGCACCCTGTACCCAGACGTTGTTGAATCCGGTGGTGGATC
TGGTACCGCAAACATCAAGAGCCACCACAACGTCGGCGGACTGCCAGACGACGTGGAATTCAAGCTCGTTGAGCCACTGC
GTGATCTGTTCAAGGACGAAGTTCGTGCCGTTGGCCGTGAACTTGGCCTCCCTGAGGAAATCGTTGGCCGCCAGCCATTC
CCAGGACCAGGACTTGGTATTCGCATCATCGGTGAAGTCACCGAAGAGCGCCTAGAAACCCTCCGCCACGCTGACCTGAT
CGCACGCACCGAGCTGACAGCAGCTGGCCTTGACGGAGTGATCTGGCAGTGCCCAGTAGTCCTCCTGGCAGATGTCCGCT
CTGTTGGTGTTCAAGGCGATGGCCGCACCTACGGACACCCAATCGTGCTGCGCCCAGTGTCTTCCGAAGACGCCATGACG
GCTGACTGGACTCGACTTCCATACGAGGTTCTTGAGAAGATCTCCACCCGCATCACCAACGAAGTTCCAGATGTGAACCG
CGTGGTTTTGGACGTAACCTCCAAGCCACCAGGAACCATTGAATGGGAGTAG

Protein sequence :
MSLQTNHRPVLVVDFGAQYAQLIARRVREAGIYSEVIPHTATADDVRAKNAAALVLSGGPSSVYAEGAPSLDAEILDLGL
PVFGICYGFQAMTHALGGTVANTGKREYGRTDINVAGGVLHEGLEACHKVWMSHGDAVSEAPEGFVVTASSEGAPVAAFE
NKERKMAGVQYHPEVLHSPHGQAVLTRFLTEIAGLEQNWTAANIAEELIEKVREQIGEDGRAICGLSGGVDSAVAGALVQ
RAIGDRLTCVFVDHGLLRAGEREQVEKDFVAATGAKLVTVDERQAFLSKLAGVTEPEAKRKAIGAEFIRSFERAVAGVLE
EAPEGSTVDFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDVEFKLVEPLRDLFKDEVRAVGRELGLPEEIVGRQPF
PGPGLGIRIIGEVTEERLETLRHADLIARTELTAAGLDGVIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMT
ADWTRLPYEVLEKISTRITNEVPDVNRVVLDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 89
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-133 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-133 51
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-133 51