Gene Information

Name : guaA (Mflv_4903)
Accession : YP_001136157.1
Strain : Mycobacterium gilvum PYR-GCK
Genome accession: NC_009338
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 5225988 - 5227556 bp
Length : 1569 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGGAATCTGCTCATCCCCGCCCCGTGTTGATCGTCGACTTCGGCGCGCAGTACGCCCAGCTCATCGCCCGGCGTGTGCG
CGAGGCCCGGGTCTTCTCGGAGGTCATCCCGCACACCGCGAGCATCGAGGAGATCAAAGCCCGCGACCCGCGGGCCGTCG
TCCTCTCCGGTGGCCCGTCCAGCGTCTACGCCGACGGCGCCCCGCAACTGGACCCCGCGCTGTTCGACCTCGACATCCCG
GTGTTCGGAATCTGCTACGGGTTCCAGGCGATGGCGCAGGCGCTGGGCGGCACCGTCGCCCGCACCGGAACCAGCGAGTA
CGGCCGTACCGAGCTGAAAGTCGCTGGCGGAGAACTTCATTCGGACCTGCCGGAGGTCCAGCCGGTGTGGATGAGCCACG
GCGACGCGGTGACGGAGGCCCCGTCGGGGTTCGAGGTCGTCGCCACCAGCGTCGGCGCACCCGTCGCGGCGTTCGAGAAC
CGCGCCCGTCGACTGGCCGGTGTGCAATATCACCCCGAGGTGATGCACAGCCCCCACGGTCAGCAGGTCCTCAGCCGCTT
CCTGCACGAATTCGCCGGTATCGATGCGGCCTGGACGCCGGCCAACATCGCCGAGGCGTTGGTCGAGCAGGTGCGCAACC
AGATCGGCGACGGGCGCGCCATCTGCGGTCTGTCCGGCGGTGTGGACTCGGCGGTGGCGGCCGCGCTGGTGCAGCGTGCC
ATCGGCGACCGGCTCACCTGCGTGTTCGTCGACCACGGCCTGCTGCGGGCGGGTGAACGGGCACAGGTTCAGCGCGATTT
CGTCGCGGCGACCGGCGCGAATCTGGTCACCGTCGACGTCGCCGACCGCTTCCTGGAAGCCCTGTCGGGGGTTACCAATC
CCGAGGGCAAGCGCAAGATCATCGGGCGCGAGTTCATCCGCGCGTTCGAGGGCGCGGTGCGTGACACGGTGGAGCGCTCG
GACGGCTCGGATGTGCCCGTGGAGTTCCTGGTCCAGGGCACCCTCTATCCCGACGTGGTGGAGTCGGGCGGCGGGTCCGG
CACCGCGAACATCAAGAGCCACCACAATGTCGGAGGCCTTCCCGACGACCTGAAGTTCGCCCTCGTGGAACCGTTGCGGC
TGCTGTTCAAGGACGAGGTGCGCGCCGTCGGTCGGGAACTCGGTCTGCCCGAGGAAATCGTTGCGCGCCAACCCTTCCCG
GGTCCGGGACTGGGCATCAGGATCATCGGCGAAGTCACCTCGGACCGGCTCGACACGCTGCGGCGCGCGGACGTCATCGC
CCGCGAGGAACTCACCGCTGCCGGGTTGGACCACCAGATCTGGCAGTGCCCGGTGGTTCTGCTGGCCGATGTCCGCTCGG
TCGGAGTGCAGGGCGACGGGCGCACCTACGGCCATCCGATCGTGCTCCGACCGGTGTCGAGCGAGGACGCGATGACGGCG
GACTGGACGCGGGTGCCTTACGAAGTGCTGGAACGGATCTCGACCCGGATCACCAACGAGGTGCCCGAGGTGAATCGGGT
GGTGCTCGACATCACCAGCAAGCCGCCGGGCACCATCGAATGGGAGTGA

Protein sequence :
MESAHPRPVLIVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIKARDPRAVVLSGGPSSVYADGAPQLDPALFDLDIP
VFGICYGFQAMAQALGGTVARTGTSEYGRTELKVAGGELHSDLPEVQPVWMSHGDAVTEAPSGFEVVATSVGAPVAAFEN
RARRLAGVQYHPEVMHSPHGQQVLSRFLHEFAGIDAAWTPANIAEALVEQVRNQIGDGRAICGLSGGVDSAVAAALVQRA
IGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDVADRFLEALSGVTNPEGKRKIIGREFIRAFEGAVRDTVERS
DGSDVPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFALVEPLRLLFKDEVRAVGRELGLPEEIVARQPFP
GPGLGIRIIGEVTSDRLDTLRRADVIAREELTAAGLDHQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTA
DWTRVPYEVLERISTRITNEVPEVNRVVLDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 78
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-136 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-136 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-136 52