Gene Information

Name : tpx (Mflv_3254)
Accession : YP_001134519.1
Strain : Mycobacterium gilvum PYR-GCK
Genome accession: NC_009338
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : -
Position : 3445056 - 3445553 bp
Length : 498 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGGCACAGATCACTTTGCGTGGAAACCCGATCAACACCGTCGGAGAGCTGCCCTCGGTCGGCTCCGCGGCACCTGGCTT
CACGCTCACCGGAACGGATCTCGGCACGGTCAGCGACGAGCAGTTCCGCGGCAAGCCCCTGCTGCTCAACATCTTCCCGT
CGGTCGACACCCCTGTCTGCTCGGCGAGCGTCCGCAAGTTCAACGAGGCGGCGGCATCCAGCGGTGTGACCGTGCTGAAC
GTCTCCAACGATCTGCCGTTCGCGCAGAAGCGCTTCTGCGGCGCCGAGGGCATCGAGAACGTGACGTCGGCGTCGGGATT
CCGCGACAGCTTCGGCGATGATTTCGGGATCAAGATCGTCGACGGCCCGATGGCCGGACTGCTCGGCCGCGCGGTGGTCG
TGGTCGATGGCGACGGCAAGGTCACCTACACCGAGCTCGTTCCCGAGATCGGTCAGGAGCCCGACTACGACGCCGCTCTC
TCCGCGCTCAAGGCGTGA

Protein sequence : 
MAQITLRGNPINTVGELPSVGSAAPGFTLTGTDLGTVSDEQFRGKPLLLNIFPSVDTPVCSASVRKFNEAAASSGVTVLN
VSNDLPFAQKRFCGAEGIENVTSASGFRDSFGDDFGIKIVDGPMAGLLGRAVVVVDGDGKVTYTELVPEIGQEPDYDAAL
SALKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 1e-33 47
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 1e-33 47
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 1e-33 47
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 1e-33 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001134519.1 thiol peroxidase VFG0087 Protein 4e-34 47