Gene Information

Name : Mflv_2691 (Mflv_2691)
Accession : YP_001133956.1
Strain : Mycobacterium gilvum PYR-GCK
Genome accession: NC_009338
Putative virulence/resistance : Virulence
Product : AMP-dependent synthetase and ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 2821319 - 2822992 bp
Length : 1674 bp
Strand : -
Note : PFAM: AMP-dependent synthetase and ligase; KEGG: mva:Mvan_3850 AMP-dependent synthetase and ligase

DNA sequence :
ATGACCACTGGATTCCCGATCGAATACGGCCATGGCCTAACAAACGGCGACCTGAAGCACGGCTTCGTCCCCTTCCCCGA
GGATCGCGCCGAGGCCTACCGGCGGGCCGGCTATTGGACGGGACGGCCGCTCGACTCGATCCTGACCGACGCGGCCTCCC
GGTGGCCGGACAAGCCGGCGATCATCGACGCCACGCGCAGCTACACGTTCGCCGAGCTGGACGCCGCCGCCGACCGGGCC
GCCGCGGGGCTGGCCGACCTCGGCATCCGCCCGGGAGAGCGGGTGCTGCTGCAGCTGCCGAACTCGTGCCAGTTCGCCGT
CGCGCTCTTCGCCCTGCTGCGGGCCGGCGTCGTACCCGTGATGTGCCTGACCGGGCACCGTACGGCAGAACTCGGTCACT
TCGCCGACGTCAGCGGCGCGGTCGCGGTGATCGTTCCCGACCGGGCGGGAGGGTTCGACTACCGCGACATGGCGGCCTCG
CTCGCCGCGCAACGTCCGGCACTGCGCCACGTGATCGTCGACGGCGAACCCGGCGATCAGGTCTCGTGGCAGTCGATCCT
CGACTTCGCCGGGCCACGTCTCGGGCGCACGCCAGTCGATCCGTCGCTTCCGGCGCTGTTGCTGGTCTCGGGCGGAACCA
CGGGGCTGCCCAAGCTCATCGCACGCACCCACGACGACTACGTCTACAACGCGCATGCCTGCGCGCAGGCATGCGAGATG
ACCGGTGAGGACGCCTATCTCGTTGCGCTGCCCGCGGGGCACAACTTCCCGCTGGCCTGTCCCGGGCTGCTCGGGTCGAT
GACGGTCGGAGCGCCGACGGTGTTCACCGCAGACCCCAGCCCGGAGAACGCCTTCGCGTTGATCGACAAGCATCGGATCA
CGGTGACCGGGTTGGTGAACGCACTGGCCAAGTTGTGGGCGCAGGCGTGCGACTGGGAGCCGGTGCTGCCGACGTCACTG
CGGTTCGTCCAGGTCGGCGGGTCGCGGATGAGCCCGGAGGAAGCGCGTTTCATCCTCGACCGGCTCACCCCGGGAATGTC
GCAGATCTTCGGCATGGCCGAGGGGATGCTCAACTTCACCCGGCCCGGCGATCCCGAGGACGTCGTGGTGCACACGCAGG
GACGGCCGATGTCGCCGCACGACGAGATGCGCGTCGTCGACGAGGACGGTGTCGAGGTCGCACCCGGCGAGGAGGGCGAG
CTGCTGGTCCGGGGGCCCTACACGCTCAATGGGTACTACCGGGCCGACGACGCCAACGCCCGCTCCTTCACGCCGGACGG
CTTCTACCGCACGGGTGACCGGGTCCGGATCTTCACCGACGGGCCCCGTGCCGGGTACGTCGAGGTCACCGGCCGGGTCA
AGGACGTGATCCACCGCGGTGGTGAGACGGTGTCGGCGACCGACCTTGAGGATCACCTGCACACCCACCCGTCCGTCTAC
GCGGCGGCCGCAGTGGCGCTGCCCGACGAGTACCTGGGCGAGAAAATCTGCGCTGCAGTCGTTTTCACGGGACCGCCGCT
CACGCTCGCCGATCTCAATGCCTTCCTCGACGAGCGCGGCGCCTCCACGCACGCGCGTCCCGATGTGCTGGTTCCGGTAC
CGTCGCTGCCGACGACAGCGGTGGGCAAGGTCGACAAGAAGGCACTCGTGGCGCAGTTGACGGCGAATTCCTAG

Protein sequence :
MTTGFPIEYGHGLTNGDLKHGFVPFPEDRAEAYRRAGYWTGRPLDSILTDAASRWPDKPAIIDATRSYTFAELDAAADRA
AAGLADLGIRPGERVLLQLPNSCQFAVALFALLRAGVVPVMCLTGHRTAELGHFADVSGAVAVIVPDRAGGFDYRDMAAS
LAAQRPALRHVIVDGEPGDQVSWQSILDFAGPRLGRTPVDPSLPALLLVSGGTTGLPKLIARTHDDYVYNAHACAQACEM
TGEDAYLVALPAGHNFPLACPGLLGSMTVGAPTVFTADPSPENAFALIDKHRITVTGLVNALAKLWAQACDWEPVLPTSL
RFVQVGGSRMSPEEARFILDRLTPGMSQIFGMAEGMLNFTRPGDPEDVVVHTQGRPMSPHDEMRVVDEDGVEVAPGEEGE
LLVRGPYTLNGYYRADDANARSFTPDGFYRTGDRVRIFTDGPRAGYVEVTGRVKDVIHRGGETVSATDLEDHLHTHPSVY
AAAAVALPDEYLGEKICAAVVFTGPPLTLADLNAFLDERGASTHARPDVLVPVPSLPTTAVGKVDKKALVAQLTANS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-92 44
ybtE CAA21394.1 - Virulence HPI Protein 7e-92 44
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 5e-92 44
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 9e-92 44
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-92 44
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 7e-92 44
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 7e-92 44
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-90 44
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-90 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mflv_2691 YP_001133956.1 AMP-dependent synthetase and ligase VFG1817 Protein 2e-170 65
Mflv_2691 YP_001133956.1 AMP-dependent synthetase and ligase VFG0168 Protein 6e-88 42
Mflv_2691 YP_001133956.1 AMP-dependent synthetase and ligase VFG0932 Protein 1e-83 41