Gene Information

Name : Mflv_2046 (Mflv_2046)
Accession : YP_001133312.1
Strain : Mycobacterium gilvum PYR-GCK
Genome accession: NC_009338
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 2124804 - 2125976 bp
Length : 1173 bp
Strand : +
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
ATGGGTGAGCAGCGCAGTAACGCAGACCGGTACCGGGCCTACGGACCCGCGACCAAGGCCATTCATGCCGGTTACCGGCC
CGATCCGGCCACCGGTGTGGTCAATCCGCCGATCTATGCGAGCTCCACGTTCGCCCAGGACGGTGTCGGCGGGCTGCGCG
GCGGGTTCGAGTACGCCCGCACCGGGAACCCGACCCGGTCCGTCCTGGAGTCGGCGCTGGCCGCGATGGAGGGCGCCTCC
TACGGGCGTGCGTTCTCCTCAGGGATGGCCGCCACCGATTGCGTGCTGCGTGCGGTGCTGCGGCCGGGCGATCACATCGT
GATCCCCGACGACGCCTACGGCGGCACGTTCCGGCTGATCGACAAGGTCTTCAGCCTGTGGGGTATCAGCTACACCGCCG
TCGCGCTGTCGGATCTCGACCGGGTGCGCGCCGCGATCACCGACCGCACGCGACTCGTCTGGATCGAGACCCCGACCAAC
CCGCTGCTGTCGATCGCCGACATCGCGGCGATCTCGGCGCTGGGCGCCGAGAAGGACGTGAAAGTGTTGGTGGACAACAC
CTTCGCCTCGCCGGCACTTCAGCAGCCGCTCGCGCTGGGGGCCGATATCGTGCTGCACTCGACGACGAAGTACATCGGCG
GACACTCCGATGTGGTCGGGGGAGCGGTGCTGACCAACGACGAGGCACTCGACGGCGCGTTCGCGTTCCTGCAGAACGGC
GCCGGTGCCGTGCCGGGACCGTTCGACGCGTACCTGACGATCCGCGGGCTCAAGACGCTGCCGTTGCGGATGCAGCGGCA
CAGCGAAAACGCCACTGCCGTCGCGGAGTTCCTCGACGGACACCCCGCGGTCGACACCGTGCTGTACCCGGGGCTGCCGT
CGCATCCGGGGCACGAGGTCGCGGCGCGGCAGATGAGCGGTTTCGGCGGGATGATCTCGGTGCGGCTCGCCGGCGGACCG
CAGGCCGCACGCGACTTCTGTGCGCGCACAGAGATTTTCATTCTCGCCGAGTCGTTGGGCGGCGTGGAGTCGCTGATCGA
GTATCCGGGTGCGATGACGCACGCCTCCACGGCGGGTTCGCAACTGGAGGTGCCCGACGACCTGGTGCGGCTGTCGGTCG
GGATCGAGGACGTGGCCGATCTCGTCGGCGACGTGGAACAGGCGCTCGGCTAG

Protein sequence :
MGEQRSNADRYRAYGPATKAIHAGYRPDPATGVVNPPIYASSTFAQDGVGGLRGGFEYARTGNPTRSVLESALAAMEGAS
YGRAFSSGMAATDCVLRAVLRPGDHIVIPDDAYGGTFRLIDKVFSLWGISYTAVALSDLDRVRAAITDRTRLVWIETPTN
PLLSIADIAAISALGAEKDVKVLVDNTFASPALQQPLALGADIVLHSTTKYIGGHSDVVGGAVLTNDEALDGAFAFLQNG
AGAVPGPFDAYLTIRGLKTLPLRMQRHSENATAVAEFLDGHPAVDTVLYPGLPSHPGHEVAARQMSGFGGMISVRLAGGP
QAARDFCARTEIFILAESLGGVESLIEYPGAMTHASTAGSQLEVPDDLVRLSVGIEDVADLVGDVEQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-70 47
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-69 46
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 7e-53 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Mflv_2046 YP_001133312.1 cystathionine gamma-synthase BAC0207 Protein 6e-62 42