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Name : leuS (SpyM50141) Accession : YP_001127737.1 Strain : Streptococcus pyogenes Manfredo Genome accession: NC_009332 Putative virulence/resistance : Unknown Product : leucyl-tRNA synthetase Function : - COG functional category : J : Translation, ribosomal structure and biogenesis COG ID : COG0495 EC number : 6.1.1.4 Position : 158957 - 161458 bp Length : 2502 bp Strand : + Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl DNA sequence : ATGACATTTTACGATCACACCGCTATTGAACCCAAATGGCAAGCCTTTTGGGCAGATAATCACACCTTTAAAACAGGAAC AGACGCATCAAAACCTAAGTTTTATGCCCTAGATATGTTCCCATACCCATCAGGAGCTGGTCTCCACGTTGGTCACCCAG AAGGCTATACAGCAACTGATATTCTCAGCCGTTTCAAACGTGCCCAAGGTCACAATGTCCTCCACCCAATGGGTTGGGAT GCCTTTGGACTTCCTGCTGAGCAGTACGCTATGGATACTGGTAATGACCCAGCCGAGTTTACAGCTGAAAACATCGCTAA CTTCAAACGCCAGATTAATGCTCTTGGTTTCTCATACGACTGGGATCGTGAAGTTAACACAACTGACCCTAACTACTACA AGTGGACGCAGTGGATCTTTACCAAGCTTTATGAAAAAGGTCTAGCCTACGAAGCTGAAGTTCCCGTTAACTGGGTTGAA GAATTGGGAACAGCTATCGCCAACGAAGAGGTTCTTCCAGATGGGACATCAGAGCGTGGCGGCTACCCAGTTGTCAGAAA ACCCATGCGCCAATGGATGCTCAAAATCACTGCCTATGCAGAGCGCTTGCTAGAAGACCTGGAAGAAGTTGACTGGCCCG AATCAATCAAGGACATGCAACGCAACTGGATTGGTAAATCAACTGGTGCTAATGTAACCTTCAAGGTTAAGGATACAGAT AAGGACTTCACTGTCTTCACAACACGTCCTGACACGCTTTTTGGTGCAACTTACGCGGTTCTTGCTCCTGAGCATGCCTT GGTTGATGCTATTACGACAGCTGACCAGGCAGAAGCCGTTGCTGACTACAAACGTCAAGCAAGTCTCAAATCAGACCTTG CTCGTACAGACCTTGCCAAAGAAAAAACAGGTGTTTGGACGGGTAGCTACGCTATTAACCCAGTTAATGGTAACGAAATG CCAGTTTGGATTGCGGACTATGTCCTTGCTAGCTACGGTACTGGAGCTATCATGGCTGTTCCAGCCCACGATGAACGTGA CTGGGAATTCGCAAAACAATTTAACCTAGACATCATCCCTGTTCTTGAAGGTGGTAATGTTGAAGAGGCTGCCTTTACAG AAGACGGTCTTCACATCAACTCAGGCTTCCTAGATGGTCTTGACAAAGCGTCAGCTATTGCCAAAATGGTCGAATGGCTT GAAGCAGAAGGCGTCGGTAATGAAAAAGTCACTTACCGTCTCCGTGACTGGCTCTTTAGCCGTCAACGTTACTGGGGTGA GCCAATCCCAATTATCCACTGGGAAGATGGTACATCAACAGCGGTTCCTGAGAGTGAATTGCCATTGGTTCTTCCAGTAA CTAAGGATATTCGTCCTTCAGGTACTGGTGAGAGCCCGCTTGCTAACGTGACAGACTGGTTGGAAGTTACCCGTGAAGAT GGTGTTAAAGGTCGTCGTGAGACTAACACCATGCCACAATGGGCAGGTTCAAGCTGGTATTATCTTCGTTACATCGATCC ACACAACACCGAAAAACTGGCTGATGAGGAACTCCTCAAACAATGGTTGCCAGTTGATATCTATGTCGGTGGTGCAGAGC ATGCCGTGCTTCACCTTCTCTACGCTCGCTTCTGGCACAAGGTTCTTTACGATCTCGGTGTTGTACCTACCAAAGAGCCA TTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGGACAAGCTACCGCGATAGCCGTGGAGCGCTTGTAGCGACTGACAA GGTTGAAAAACGTGATGGCAGCTTCTTCCATTTGGAAACTGGTGAAGAGCTTGAACAAGCACCAGCTAAGATGTCTAAAT CACTTAAGAACGTTGTCAACCCAGATGATGTTGTTGAGCAGTACGGTGCTGACACCCTTCGTGTTTACGAGATGTTCATG GGACCACTTGACGCTTCCATCGCTTGGTCTGAAGAAGGTCTTGAAGGCTCACGTAAGTTCTTGGACCGTGTTTACCGTTT GATCACGACTAAAGAGATCACTGAGGAAAATAGCGGAGCCCTTGACAAGGTTTACAACGAAACCGTTAAGGCCGTTACTG AGCAAGTTGACCAAATGAAATTCAACACAGCTATCGCTCAACTCATGGTATTTGTCAATGCAGCCAACAAGGAAGACAAA CTCTTTAGCGACTATGCCAAAGGCTTTGTTCAATTGATTGCACCATTTGCACCGCACTTAGGTGAGGAACTCTGGCAAGC CTTGACAGCCTCAGGTGAGTCAATCTCTTACGTGCCATGGCCAAGTTATGATGAAAGCAAATTGGTTGAAAACGATGTGG AAATCGTTGTCCAAATCAAAGGTAAGGTCAAAGCTAAACTTGTAGTTGCTAAAGACCTTTCACGCGAAGAATTACAAGAA GTTGCCCTTGCTAACGAAAAAGTCCAAGCCGAAATCGCAGGCAAAGACATCATCAAAGTCATCGCAGTACCAAACAAACT CGTTAATATTGTTATCAAATAG Protein sequence : MTFYDHTAIEPKWQAFWADNHTFKTGTDASKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRFKRAQGHNVLHPMGWD AFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVE ELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLEDLEEVDWPESIKDMQRNWIGKSTGANVTFKVKDTD KDFTVFTTRPDTLFGATYAVLAPEHALVDAITTADQAEAVADYKRQASLKSDLARTDLAKEKTGVWTGSYAINPVNGNEM PVWIADYVLASYGTGAIMAVPAHDERDWEFAKQFNLDIIPVLEGGNVEEAAFTEDGLHINSGFLDGLDKASAIAKMVEWL EAEGVGNEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPESELPLVLPVTKDIRPSGTGESPLANVTDWLEVTRED GVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEELLKQWLPVDIYVGGAEHAVLHLLYARFWHKVLYDLGVVPTKEP FQKLFNQGMILGTSYRDSRGALVATDKVEKRDGSFFHLETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFM GPLDASIAWSEEGLEGSRKFLDRVYRLITTKEITEENSGALDKVYNETVKAVTEQVDQMKFNTAIAQLMVFVNAANKEDK LFSDYAKGFVQLIAPFAPHLGEELWQALTASGESISYVPWPSYDESKLVENDVEIVVQIKGKVKAKLVVAKDLSREELQE VALANEKVQAEIAGKDIIKVIAVPNKLVNIVIK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| leuS | YP_281511.2 | leucyl-tRNA synthetase | Not tested | Not named | Protein | 0.0 | 99 |
