Gene Information

Name : GTNG_0078 (GTNG_0078)
Accession : YP_001124210.1
Strain : Geobacillus thermodenitrificans NG80-2
Genome accession: NC_009328
Putative virulence/resistance : Virulence
Product : negative regulator of genetic competence ClpC/MecB
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 94900 - 97335 bp
Length : 2436 bp
Strand : +
Note : -

DNA sequence :
ATGATGTTCGGCAGATTTACGGAACGGGCGCAAAAGGTATTGGCGTTGGCACAGGAAGAAGCCATTCGCCTTGGCCATAA
CAATATTGGCACAGAGCACATTTTGCTTGGGTTGATCCGCGAAGGAGAAGGAATCGCCGCTAAAGCGCTTATGGCGCTTG
GCCTTGGTCCAGATAAAATTCAGAAAGAAGTGGAATCGCTCATTGGCCGTGGGAACGAGGTATCACATACGATTCACTAC
ACACCGCGGGCGAAGAAAGTGATTGAGCTGTCAATGGATGAAGCGCGGAAGCTCGGTCATTCGTACGTCGGCACGGAACA
TATTTTGCTTGGATTGATCCGCGAGGGCGAAGGAGTGGCCGCCCGCGTGTTAAACAACTTAGGGGTGAGCTTGAACAAGG
CGCGCCAACAAGTATTGCAGCTGCTCGGCAGCAATGAATCAGTATCGGGCCATGGTGGTGGAGGTGCCTCGCATGTAAAC
ACGCCGACGCTTGACAGCCTCGCCCGTGATTTAACGGCGATCGCCCGTGAAGGGCGGCTTGATCCGGTCATTGGCCGGAG
CAAAGAAATCCAGCGCGTTATTGAAGTGTTGAGCCGACGGACGAAAAACAACCCGGTGCTGATCGGTGAACCGGGTGTCG
GGAAAACAGCGATCGCCGAAGGATTGGCTCAACAAATTGTCAATAACGAGGTGCCGGAAACGTTGCGCGACAAGCGGGTC
ATGACGCTCGATATGGGTACAGTTGTGGCCGGGACGAAATACCGTGGCGAGTTTGAGGATCGGTTGAAAAAAGTGATGGA
TGAGATTCGCCAAGCAGGCAACATCATTTTGTTCATCGATGAGCTCCATACGCTAATCGGCGCTGGCGGAGCCGAAGGAG
CGATCGATGCATCGAACATTTTAAAACCAGCGTTGGCGCGTGGCGAACTGCAATGCATTGGAGCGACGACGCTTGATGAG
TATCGGAAATATATCGAGAAAGATGCCGCGCTTGAGCGCCGTTTCCAGCCGATTCATGTCGATGAGCCAACTGTGGAAGA
ATCGATCCAAATTTTAAAAGGGCTGCGCGACCGTTATGAAGCGCACCATCGCGTCTCGATTTCCGATGAGGCGATCGTGC
AGGCGGTCAAACTGTCGGACCGTTACATTACCGACCGTTTTCTGCCGGATAAAGCGATCGACTTAATTGATGAAGCTTGC
TCAAAAGTGCGCCTCCGCTCGTTCACGGCGCCGCCGAAACTGAAAGAGCTGGAGCAAAAGCTCGAGGAAGTGCGGAAAGA
AAAAGACGCGGCCGTACAAAGCCAAGAGTTTGAAAAAGCAGCCTCGTTGCGTGATATGGAACAACGGTTGCGCGAAGAGC
TCGAGGAAACAAAACGGGCATGGAAAGAAAAGCAAGGTCAAGAAAATTCTGAGGTGACAGTTGAAGATATTGCTGCAGTT
GTCTCGAGTTGGACCGGCATTCCGGTATCGAAACTCGCTGAGACGGAAACGGAGCGGTTGCTCAAGCTTGAAGAAATTTT
GCATGCGCGCGTTGTCGGCCAAGACGAGGCGGTCAAAGCGGTTGCGAAAGCCGTGCGCCGTGCCCGGGCCGGTTTGAAAG
ACCCGAAACGCCCGATCGGTTCATTTATTTTCCTCGGTCCGACAGGTGTCGGGAAAACAGAATTGGCCCGCGCATTGGCA
GAAGCCATGTTTGGCGATGAAGACGCCCTGATCCGCATCGATATGTCCGAGTATATGGAAAAACACTCGACATCGCGGCT
CATCGGTTCGCCGCCAGGGTATGTCGGCTACGAAGAAGGCGGCCAGCTGACAGAAAAAGTGCGTCGCAAGCCGTACTCGG
TCGTTCTGTTGGATGAAATGGAAAAAGCGCACCCAGACGTATTTAACATTTTGCTGCAAGTATTAGAAGACGGGCGGTTG
ACTGACTCGAAAGGGCGGACGGTCGACTTCCGCAATACGATTATCATTATGACGTCCAATGTTGGTGCTGATGCGCTGAA
ACGGAACAAGTACGTCGGCTTTAATATTCAAGATGGGAACCAACAATATAAGGACATGAAAGGCAAAGTGATGGATGAAC
TGAAAAAAGCGTTCCGTCCGGAGTTTTTGAACCGGATCGATGAAATCATCGTCTTCCATTCACTCGAAAAAGACCATCTG
AAACAAATTGTCCGCTTGATGGCTGATACGCTTGTGAAGCGGCTGAAGGAACAAGATATCGATCTTGAACTGACTGAAGC
AGCGATTGAGAAAATTGCTGCCGAAGGGTTTGATCTGGAATACGGTGCCCGTCCGCTGCGCCGCGCCTTGCAAAAACATA
TTGAAGACCGTTTGTCCGAAGAATTATTAAAAGGCACGATCGCCAAAGGTCAAAAAGTTGCTGTCGATGTGAAAGATGGA
GAATTTGTCGTGTTGTCGAAACAGGCGGTCGTGTAA

Protein sequence :
MMFGRFTERAQKVLALAQEEAIRLGHNNIGTEHILLGLIREGEGIAAKALMALGLGPDKIQKEVESLIGRGNEVSHTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNESVSGHGGGGASHVN
TPTLDSLARDLTAIAREGRLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIVNNEVPETLRDKRV
MTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPALARGELQCIGATTLDE
YRKYIEKDAALERRFQPIHVDEPTVEESIQILKGLRDRYEAHHRVSISDEAIVQAVKLSDRYITDRFLPDKAIDLIDEAC
SKVRLRSFTAPPKLKELEQKLEEVRKEKDAAVQSQEFEKAASLRDMEQRLREELEETKRAWKEKQGQENSEVTVEDIAAV
VSSWTGIPVSKLAETETERLLKLEEILHARVVGQDEAVKAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALA
EAMFGDEDALIRIDMSEYMEKHSTSRLIGSPPGYVGYEEGGQLTEKVRRKPYSVVLLDEMEKAHPDVFNILLQVLEDGRL
TDSKGRTVDFRNTIIIMTSNVGADALKRNKYVGFNIQDGNQQYKDMKGKVMDELKKAFRPEFLNRIDEIIVFHSLEKDHL
KQIVRLMADTLVKRLKEQDIDLELTEAAIEKIAAEGFDLEYGARPLRRALQKHIEDRLSEELLKGTIAKGQKVAVDVKDG
EFVVLSKQAVV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 0.0 59
STY0294 NP_454876.1 ClpB-like protein Not tested SPI-6 Protein 2e-89 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
GTNG_0078 YP_001124210.1 negative regulator of genetic competence ClpC/MecB VFG0079 Protein 0.0 78
GTNG_0078 YP_001124210.1 negative regulator of genetic competence ClpC/MecB VFG0080 Protein 5e-140 54