Gene Information

Name : dhbE (SACE_3853)
Accession : YP_001106049.1
Strain : Saccharopolyspora erythraea NRRL 2338
Genome accession: NC_009142
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 4216632 - 4218257 bp
Length : 1626 bp
Strand : -
Note : -

DNA sequence : 
TTGACTGACGACGAGATCCTGCCTGGGTGTCCGACCTGGCCCGCCGAGTTCGCCGAACGCTACCGGGCGGCCGGCTACTG
GCGCGGTGAGACCTTCGGCCGGATGCTGCGGGACCGCGCGAACGCCCACCCCGACCGGGTCGCGGTGGTCGACGGCGACC
GCAGGACCACCTACGGCGAGCTCGACGCGCGCGCCGACCGCCTGGCCGCCGGCCTGCGCGGGCTCGGCATCACCGCCCGC
GACCGCGTCGTGGTGCAGCTGCCCAACATCGCCGAGTTCTTCGACGTCTGCTTCGCGCTGTTCCGCATCGGAGCCGTCCC
GGTCTTCGCGCTGCCCTCGCACCGGCTGACCGAGATCGGCTACTTCTGCGAGTTCAGCGAGGCGGTCGCCTGCATCACCA
CCGACGTCGAGGCGGGCTTCGACCACCGGGTGCCGGCCGCCGAGGTCGCTCGGCGGGTGCCGGGGCTGCGCCAGGTCCTC
ATCGCGGGAGACCCGGGCGACTCCGGTTTCATCGCGCTGGAGCAGATCGACGGCGAGCCGACGGACGACCCGGGCCCGCG
GCCGGGCGACATCGCCTTCCTCCAGCTCTCGGGCGGGAGCACCGGCGTGCCCAAGCTGATCCCGCGCACGCACGACGACT
ACATCTACTCCTTCCGTGCCAGCAACGACATCTGCGGCGTCACCGAGGACACCGTCTACCTCGGCGCGCTGCCGATCGCG
CACAACTTCCCGATGAGCTCGCCCGGCACGTTCGGCGTCCTGCACGCCGGGGGCCGCGTCGTGCTGGCGCGCAGGCCGAG
CCCGGACGAGGTCTTCCCGCTCGTGGAACGCGAACGCGTCACGATGGTCGCCGCGGTCCCGCCGCTGGCGCTGGTCTGGC
TGGACGCCGCGGCCGGCACCGAGCACGACCTGTCGAGCCTCCAGGTGCTGCAGGTAGGCGGCGCCAAGTGCAGCGAGGAG
GTCGCGCGCCGGGTCCGGCCGGTTCTGGGCGCCACCCTCCAGCAGGTGTTCGGCATGGCCGAGGGGCTGGTGAACTACAC
CCGCCTCGACGATCCGGAGGAGGTCGTGCTCACCACGCAGGGCAGGCCGATCTCCCCCGGCGACGAGGTGCTGGTGGTGG
ACGACGGCGACCGGCCGGTCGCCGCAGGGGAGACCGGGCACCTGCTCACGCGCGGCCCCTACACGATCCGCGGCTACTAC
AAGGCCGACGAGCACAACGCCAAGGCGTTCACCCCGGACGGTTTCTACCGCACCGGCGACGTCGTGGTCGAGGGCAGGGC
CAAGGACCAGATCAACCGCGGCGGCGAGAAGGTGGCCGCCGAGGAGGTCGAGAACCACCTGCTGGCCCACCCGGCGGTGC
ACGACGCGGCGGTGGTGTCGATGCCCGACGACTACCTGGGCGAGCGCACCTGCGCCTTCGTGGTCCCGCGCGGCACGCCG
CCGAAGGCCCGCGAGCTCATCCGGTTCGTCCGGGAGCGCGGGCTCGCCGGGTACAAGGTTCCGGACCGGGTGGAGTTCCT
CGAGCGGTTCCCTCGGACCGGGGTGGGCAAGGTCAGCAAGCGAGACCTCCGGGAGGTCATCAGCCGCGAGCTGGTACCGG
AGCTCGGCAAGGACGCAGGACGATGA

Protein sequence : 
MTDDEILPGCPTWPAEFAERYRAAGYWRGETFGRMLRDRANAHPDRVAVVDGDRRTTYGELDARADRLAAGLRGLGITAR
DRVVVQLPNIAEFFDVCFALFRIGAVPVFALPSHRLTEIGYFCEFSEAVACITTDVEAGFDHRVPAAEVARRVPGLRQVL
IAGDPGDSGFIALEQIDGEPTDDPGPRPGDIAFLQLSGGSTGVPKLIPRTHDDYIYSFRASNDICGVTEDTVYLGALPIA
HNFPMSSPGTFGVLHAGGRVVLARRPSPDEVFPLVERERVTMVAAVPPLALVWLDAAAGTEHDLSSLQVLQVGGAKCSEE
VARRVRPVLGATLQQVFGMAEGLVNYTRLDDPEEVVLTTQGRPISPGDEVLVVDDGDRPVAAGETGHLLTRGPYTIRGYY
KADEHNAKAFTPDGFYRTGDVVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAVVSMPDDYLGERTCAFVVPRGTP
PKARELIRFVRERGLAGYKVPDRVEFLERFPRTGVGKVSKRDLREVISRELVPELGKDAGR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 3e-107 49
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 5e-107 49
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-107 49
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 5e-107 49
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-107 49
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-107 49
ybtE CAA21394.1 - Virulence HPI Protein 5e-107 49
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-105 48
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 4e-105 48

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
dhbE YP_001106049.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 5e-130 55
dhbE YP_001106049.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 2e-103 49
dhbE YP_001106049.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 2e-101 48