Gene Information

Name : dhbE (SACE_2694)
Accession : YP_001104901.1
Strain : Saccharopolyspora erythraea NRRL 2338
Genome accession: NC_009142
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 2947991 - 2949655 bp
Length : 1665 bp
Strand : +
Note : -

DNA sequence : 
ATGAACGCGATGCCCGCACTCGACGGGTTCACACCCTGGCCCGGTGAGCTCGCCGACCACTACCGGAACGCGGGTCACTG
GCGCGACGAGACGCTGGGCGGCCTGCTCCGGACCTGGGCGGCGCGCTCGGGTGACGCGCCGGCCGTCGTGGCCGAGAACG
TCGGCTCGGCACGACGACTTTCCTACGCCGAACTCGATGGCCGGGTGGATGCGACCGCCGCGGGGCTGCGTGCGCTGGGC
ATCGCCGCTCGCGACCGAGTCGTGGTCCACCTGCCGAACACGCTCGACTTCGTCGTCGTGTTCTTCGCTCTGCTGCGGTG
CGGCGCCGTGCCGGTGCTGGCGCTGCCCGCGCACCGGCAGTCCGAGATCGAACACTTCGTCACCCTCAGCGAGGCCGTGG
CCTACGTGGTTCCCGACGAGCACGAAGGGTTCGACTTCCGCGGACTGGCCGCTGACGTGGCCGCCAAGGCGCCCTCGCTG
CGGCACGTGTTGGTCTCCGGCGATCCCGGCCCCTTCACCGCGCTCGACGCGCTGCCGGCAGGCTCGGCCGAACCGCTTCC
CGAAGCCGATCCGGGTGACGTCGCCGTTCTGCTCATTTCGGGCGGGACGACGGGAAAGCCCAAGCTCATCCCGCGCACTC
ACCGGGACTACGCCTACAACGCGCGAGCCAGCGCCGAGGTGTGCGCGCTGACCTCCGACGACGTCTACCTCGCGAGCCTG
CCCGTCGCGCACAACTTCCCCCTCGCGTGCCCTGGGCTCCTCGGGGTGCTGGGTGCAGGCGGGACCGTTGTGCTGTCCCC
CTCGCCGAGTCCCGACGTCGGGTTGCGGCTCGTGGAAAGGCATCGGGTGACCGTCACCGCGCTGGTGCCGCCCATGGTCC
GGATGTGGGTGGACGTGGCGGCGTGGGACACCCACGACCGGTCGAGCCTGCGGCTGCTCCAGGTGGGCGGGGCCAAGCTC
GACGACGGGTTGGCGCGGCAGGTCACGCCCGCTCTGGGCTGCCGGTTGCAACAGGTCTTCGGGATGGCTGAGGGACTGCT
CAACTACACCCGCCTCGATGATCCGGACGAGCTCGTCTTCGGTACCCAGGGCAGACCGCTGTCACCCGACGACGAGGTGC
GCGTGGTCGACGAGAACGGTGATCCGGTCGCTCCCGGTGAGGTGGGGGAGCTGTGGACGCGCGGCCCGTACACGCTGCGC
GGCTACTACCGCGTGCCGGAGTACAACGCGACGTCGTTCACCCCCGACGGCTTCTACCGGAGCGGCGATCTCGTGCGTCA
GCTGCCGAGCGGACATCTGGTCGTCGAGGGGCGGCGCAAGGACGTCATCAACCGCGGTGGTGAGAACGTGTCCGCCGCCA
CCCTCGAAGAGCACCTGCTCGCGCATCCGGCGATCGCTCAGGTGGCCGTTCTGGGCCTTCCCGACGACTCGGTCGGGGAG
CGCGTGTGCGCGGTGGTCGTCCTCGCACCCGACGCCGGGCGCGCCCCGAAGCTCAAGGAGCTGCGGGCGTTCCTCATCGA
CCGCGGGCTCGCCCGGTTCATGTACCCGGACCGGCTCGTCGTGCGCGACGCGCTGCCCCTGACCGGCGTCGGCAAGATCA
ACAAGCGGGAGCTGGTCGCCGGCCTGACCGCAGGTTCCCAGGAGAAGGAAGGCGATGTCTCATGA

Protein sequence : 
MNAMPALDGFTPWPGELADHYRNAGHWRDETLGGLLRTWAARSGDAPAVVAENVGSARRLSYAELDGRVDATAAGLRALG
IAARDRVVVHLPNTLDFVVVFFALLRCGAVPVLALPAHRQSEIEHFVTLSEAVAYVVPDEHEGFDFRGLAADVAAKAPSL
RHVLVSGDPGPFTALDALPAGSAEPLPEADPGDVAVLLISGGTTGKPKLIPRTHRDYAYNARASAEVCALTSDDVYLASL
PVAHNFPLACPGLLGVLGAGGTVVLSPSPSPDVGLRLVERHRVTVTALVPPMVRMWVDVAAWDTHDRSSLRLLQVGGAKL
DDGLARQVTPALGCRLQQVFGMAEGLLNYTRLDDPDELVFGTQGRPLSPDDEVRVVDENGDPVAPGEVGELWTRGPYTLR
GYYRVPEYNATSFTPDGFYRSGDLVRQLPSGHLVVEGRRKDVINRGGENVSAATLEEHLLAHPAIAQVAVLGLPDDSVGE
RVCAVVVLAPDAGRAPKLKELRAFLIDRGLARFMYPDRLVVRDALPLTGVGKINKRELVAGLTAGSQEKEGDVS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 1e-103 49
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 1e-103 49
ybtE CAA21394.1 - Virulence HPI Protein 5e-104 49
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 4e-104 49
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 6e-104 49
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-104 49
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 5e-104 49
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-104 49
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 5e-104 49

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
dhbE YP_001104901.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 2e-123 54
dhbE YP_001104901.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 1e-110 51
dhbE YP_001104901.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 4e-96 44