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Name : ureC (SACE_2526) Accession : YP_001104743.1 Strain : Saccharopolyspora erythraea NRRL 2338 Genome accession: NC_009142 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 2734499 - 2736325 bp Length : 1827 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGACTGAGGCGCCGACCGGCCCCCGGTACAAGAATCCACTGAGCCGCTCCGAATACCTGGAGCTGTTCGGGCCGACGGT CGGTGACCGGATCCGGCTCGCCGACACCGCCTTGTCCATCCGGATCACCGAGGACTGGGCCGGCGGACCCGGACGCAGCG GCAACGAGGTCGTCTTCGGCGGCGGCAAGGTGATCCGCGAGTCGATGGGCCAGTCCGGCATCCCCCGCGACCCGGGCCCC CGGGATCAGCGCAGGCCTGCGGACACGGTCATCACCGGCGTGGTGGTGCTGGACCACTGGGGGATCGTCAAGGCGGACGT GGCCCTCCGCGACGGCAGGATCCAGGCGCTGGGCAAGGCGTACAACCCCGAAACGATGGACCCACTGCACGGGGAGAACG AAACACCCACCAACATCGTTATCGGCCCGGAGACCGAAATCATCTCAGGCAAGGGCCGCATCCTCACAGCCGGCGGCGTG GACACCCACGTGCACTTCATCTGTCCGGAACAGGTCCGAGAAGCCCTCGCGGCCGGGGTGACCACGCTGATCGGCGGCGG AACGGGTCCGGCCGAGGGGTCCACCGCCACCACCGTCACACCTGGGACGTGGCATCTGGCCCGGCTCTTCGAGGCGCTGG ACGACTTCCCGGTCAACATCGGTCTGCTCGGAAAGGGCAGCACCATGTCCAAGGCCGCGCTGTACAACCAGGTGGACGCC GGCGTTCTCGGCTTCAAGATCCACGAAGACTGGGGAGCTACCCCCGCGGTGCTCGACACCTGTCTTCAGGTCTGCGACGA CACAGGCGTGCAGCTGGCCCTGCATGCGGACTCGCTGAACGAGGCCGGCTTCGTCGACGACACGATCAAGGCCATCGACG GGCGTTGCCTGCACGTCTTCCACATCGAGGGCGCGGGCGGCGGCCACGCCCCTGACCTGATCAAGATGGTGGGTCTGGAC AACGTCCTGCCCGCTTCGACGAACCCGACCCGTCCTTTGACGGTCAACACCGTCGCGGAACACCTCGACATGATGATGGT CTGCCACCACCTCAACCCGGAGATCGAGGCGGACCTGGCCTTCGCAGACTCACGAATCCGCCCTTCCACCATGGCGGCCG AGGATCTGCTGCACGATCTGGGCGCGATCTCCATGATGTCCTCCGACGCCCAGGCCATGGGCCGCATCGGTGAGATGATC ACGCGTACCTGGCAGACCGCGCACGTGATGAAGAAGCGATACGGATTCCTGTCCGGAGACAACGGAGCGGACAACCTCCG CGCACGCCGCTACGTCGCCAAGTACACCATCAATCCCGCGATCGCCCAGGGCGTCGACCACGAGGTCGGCTCGATCGAGG TCGGCAAGCTCGCCGATCTGGTGCTGTGGGAGCCGAAGTTCTTCGGCGTGAAACCGCACATGGTCGTCAAGGGCGGCCAG ATCGCCTACGCCCAGGTGGGAGACGCCAACGCGTCGATTCCCACGCCACAGCCGATCCTGCCCCGTGCGGTGTGGGGAGC GCAGGGCCGAGCTCCCGCGGCGAACTCGTTCAACTTCGTCTCGCAGCGCGCCCTGGACAAGGGTCTGGCCCAACGGCTGG GCGTCGGCAAGAGATTCAGCGCTATCACCGACACCCGGTGCCTGAGCAAGAGCGACATGCAGGAGAACAGCGCCACGCCC GACGTCGACGTCGACCCCAACACCTACACGGTGGAAATCGGCGGTGCCGAGACATCGGACACGAAAACCTTCGTCGAGCA GCAGGAGATTTCTCTGGAGCACGTCGTCGAGGAGCTGCCGATGGCCCAGCGGTACTTCCTGTTCTGA Protein sequence : MTEAPTGPRYKNPLSRSEYLELFGPTVGDRIRLADTALSIRITEDWAGGPGRSGNEVVFGGGKVIRESMGQSGIPRDPGP RDQRRPADTVITGVVVLDHWGIVKADVALRDGRIQALGKAYNPETMDPLHGENETPTNIVIGPETEIISGKGRILTAGGV DTHVHFICPEQVREALAAGVTTLIGGGTGPAEGSTATTVTPGTWHLARLFEALDDFPVNIGLLGKGSTMSKAALYNQVDA GVLGFKIHEDWGATPAVLDTCLQVCDDTGVQLALHADSLNEAGFVDDTIKAIDGRCLHVFHIEGAGGGHAPDLIKMVGLD NVLPASTNPTRPLTVNTVAEHLDMMMVCHHLNPEIEADLAFADSRIRPSTMAAEDLLHDLGAISMMSSDAQAMGRIGEMI TRTWQTAHVMKKRYGFLSGDNGADNLRARRYVAKYTINPAIAQGVDHEVGSIEVGKLADLVLWEPKFFGVKPHMVVKGGQ IAYAQVGDANASIPTPQPILPRAVWGAQGRAPAANSFNFVSQRALDKGLAQRLGVGKRFSAITDTRCLSKSDMQENSATP DVDVDPNTYTVEIGGAETSDTKTFVEQQEISLEHVVEELPMAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 1e-144 | 54 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 1e-144 | 54 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-137 | 52 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-137 | 52 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 3e-137 | 52 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 3e-137 | 52 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_001104743.1 | urease subunit alpha | VFG0270 | Protein | 3e-136 | 52 |
