Gene Information

Name : thcA (SACE_2377)
Accession : YP_001104602.1
Strain : Saccharopolyspora erythraea NRRL 2338
Genome accession: NC_009142
Putative virulence/resistance : Virulence
Product : aldehyde dehydrogenase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1012
EC number : 1.2.1.3
Position : 2579062 - 2580585 bp
Length : 1524 bp
Strand : -
Note : -

DNA sequence :
ATGGTTCTGTATGCGGCGCCGGGTGCGGCGGGTTCGGTCGTGGAGTACCGCTCGCGCTACGACCACTTCATCGGTGGCGA
GTACGTGGCCCCGGCCGGGGGCGAGTACTTCGAGAACCCCACCCCGGTCACCGGCAAGACGTTCACCGAGATCGCCCGCG
GCACCGCAGACGACGTCGAACGCGCGCTGGACGCCGCCGAGGGCGCCGCGCCGGCGTGGGGCCGCACCCCGGCGGCCGAG
CGGGCAGGCGTCCTGCTGCGGATCGCCGACCGGATGGAGCACAACCTCGAAAAGCTCGCGGTCGCCGAGAGCTGGGAGAA
CGGCAAGCCGGTGCGCGAGACGCTGGCCGCCGACCTGCCGCTGGCCATCGACCACTTCCGCTACTTCGCCGGGGCGCTGC
GCGCCCAGGAGGGCTCGATCTCCCAGATCGACGAGGACACCGTCGCCTACCACTTCCACGAGCCGCTGGGCGTAGTCGCC
CAGATCATCCCGTGGAACTTCCCACTGCTGATGGCCACCTGGAAGCTCGCGCCCGCGCTGGCCGCGGGCAACGCCGTGGT
CCTCAAGCCCGCCGAGCAGACCCCGGCCTCGATCCACGTGCTGCTCGACCTGATCGCCGACCTGCTGCCCGCCGGCGTGC
TCAACGTGGTCAACGGCTTCGGCGTGGAGGCCGGCAAACCGCTGGCCTCCAGCCCGCGGGTGCGCAAGGTCGCCTTCACC
GGCGAGACCACCACCGGCAGGCTGATCCTGCAGTACGCCAGCCAGAACATCATCCCGGTCACCGTCGAGCTCGGCGGCAA
GAGCCCGAACATCTTCTTCGACGACGTCGCCGCCCAGCAGGACGCCTTCTACGACAAGGCACTGGAAGGCTTCACCATGT
TCGCCCTCAACCAGGGCGAGGTCTGCACCTGCCCGTCGCGGGCGCTGATCCAGTCCGGCATCTACGAGGGCTTCCTGTCC
GACGCCGTCGCGCGCACCGAGCGGATCAAGCAGGGCAACCCGCTGGACACCGACACCCAGATCGGCGCCCAGGCCAGCAA
CGACCAGCTCGAGAAGATCCTGTCCTACATCGACATCGGCAGGCAGGAAGGCGCCGAAGTCCTCACCGGCGGCCACCGCG
TCGAGCTGGAAGGCGACCTGGCGGGCGGCTACTACGTCGCGCCCACCATCTTCCAGGGCCACAACAATCAGCGCATCTTC
CAGGAAGAGATCTTCGGCCCCGTCGTCTCGGTCGCGAAGTTCGACGACTACGCCGACGCGATGAACACCGCCAACGACAC
CCTCTACGGTCTGGGCGCCGGCGTGTGGTCGCGCAACGCCGGCACCGCCTACCGGGCCGGACGCGACATCCAGGCGGGCC
GGGTGTGGGTCAACAACTACCACGCCTACCCCGCCCACGCCGCCTTCGGCGGCTACAAGCAGTCCGGCATCGGCCGCGAG
ACCCACAAGATGATGCTCGACCACTACCAGCAGACCAAGAACATGCTGGTCAGCTACTCCGACAACGCACTTGGCTTCTT
CTGA

Protein sequence :
MVLYAAPGAAGSVVEYRSRYDHFIGGEYVAPAGGEYFENPTPVTGKTFTEIARGTADDVERALDAAEGAAPAWGRTPAAE
RAGVLLRIADRMEHNLEKLAVAESWENGKPVRETLAADLPLAIDHFRYFAGALRAQEGSISQIDEDTVAYHFHEPLGVVA
QIIPWNFPLLMATWKLAPALAAGNAVVLKPAEQTPASIHVLLDLIADLLPAGVLNVVNGFGVEAGKPLASSPRVRKVAFT
GETTTGRLILQYASQNIIPVTVELGGKSPNIFFDDVAAQQDAFYDKALEGFTMFALNQGEVCTCPSRALIQSGIYEGFLS
DAVARTERIKQGNPLDTDTQIGAQASNDQLEKILSYIDIGRQEGAEVLTGGHRVELEGDLAGGYYVAPTIFQGHNNQRIF
QEEIFGPVVSVAKFDDYADAMNTANDTLYGLGAGVWSRNAGTAYRAGRDIQAGRVWVNNYHAYPAHAAFGGYKQSGIGRE
THKMMLDHYQQTKNMLVSYSDNALGFF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
VC0819 NP_230467.2 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-153 62
aldA AAK20776.1 aldehyde dehydrogenase Virulence VPI Protein 4e-160 61
aldA AAC12273.1 aldehyde dehydrogenase Virulence VPI Protein 4e-160 61
aldA AAK20747.1 aldehyde dehydrogenase Virulence VPI Protein 4e-160 61
aldA-1 YP_001216300.1 aldehyde dehydrogenase Not tested VPI-1 Protein 2e-159 61

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
thcA YP_001104602.1 aldehyde dehydrogenase VFG0082 Protein 9e-154 62