Gene Information

Name : topB (SNSL254_pSN254_0063)
Accession : YP_001101942.1
Strain :
Genome accession: NC_009140
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 43217 - 45409 bp
Length : 2193 bp
Strand : -
Note : identified by match to protein family HMM PF01131; match to protein family HMM PF01396; match to protein family HMM PF01751; match to protein family HMM TIGR01056

DNA sequence :
ATGGACCTTTATATCTGCGAGAAGCCTTCTCAGGCAAAAGATTTGGCTGGCGTAATGAAGGCCTCCCAACGAGGTGATGG
ATTTCTCCATGATGGAGGAAACCGCGTTATTACGTGGGCGTTCGGCCACCTGCTGGAATTGTATATGCCAGACGATTATG
ACGAACGCTACAAGTCATGGTCACTGGAGACCCTCCCTATTGCACCAGAGTCATGGCGGTACAACGTTCGCAAGAGTGCG
TTCAAACAGTACAAAATTGTTGAGGGACTGGTCAAAAAGGCGAGCACCATCTACATCTCAACGGACTACGACCGAGAAGG
TGAGGCTATCGCCCGTTCGCTTCTGGATCGATTCCGCTACTCTGGCCCTATTCGCCGAGTTTGTTTGACGGCTCTCGATG
AGTCAAGCATCAAGAAAGCGCTGAACAACGTAAAGGATGGCAAGGATACGGTCTCACTCTACTACGCCGCATTGGCACGG
CAACGCGCTGACTGGTTGGTAGGCATGAACGTGAGCCGCCTCTACACAGTGCTGGCCCGAGATGTCGGCTTCAACCACAC
TCTTCACGTTGGCAGGGTTATCACCCCAACCGTCGCTCTTGTTTGTCAACGGGACCGAGAGATCGCCGGTTTCACCCCCT
CACCATACTGGACTCTGGGTGTGAACGTGTCCGTACAGAATGGACAGTTTGCCGCCCAATGGATACCACCAGAAGAGTGC
AGTGACGAGCAAGGCCGGTGCGTCAATAAGGCCTATGCCGAGCAGGTAGCCTCCCAGGTCAATGGTGCCAATGCTGTTAT
CAGCAAAGCAGAAACCAAACCAGGTAAAGAGTCAGCCCCCCTCCCCTTCGATCTAACGTCGCTGCAACAATACGCGAGCA
AACGATGGGGATACACAGCTCAGCAGGTACTGGATGCAGCTCAAGCTCTGTACGAGACGCACAAAGCGACCACCTACCCT
CGTACTGACAGTCGTTATCTACCCGAGAGCCAAAAGGAAGACATTCCGGACATTCTCCAGGCGCTCATTTTGTCCGATCA
GAACGTCTCTGGGCTGGTGGCTGGCGCAGATCCTCATCGCAAGGCCAGGGTATTCAATGACGCCAAAGTGACCGCGCACC
ACGCGATCATTCCAACACCGGCCAGAACAGACATCAGTGCCATGTCTGAGATCGAGTTCAATCTTTACGACGCCATCCGT
CGTTTCTACATCGCGCAGTTCTACAGCGAGTTCGAGTTCACCAAAACCTCCATCGAGGTGCAGTGTGGGCGTCACCTCTT
TGCGTCCGCTGGTAAGACACCTACCAAACAAGGCTGGAAGGTTTTGTTTGCTTCTGATAGTGAAAGCAGTCCCAAGGACG
AGGGGGAAGACACCGACGCGCCGGTTGAACAAGAGAAGCTCCCCAGGGTTAGCCAGGGCGAACCTGCCTTGCTGAATGGG
GCCGAGCTGGCAAACAAAATGACGCGGCCAGCACCGCACTTCACCGAAGCCACATTGCTTGCCGCGATGGAGAACATTGC
CCGGTTCGTGACTGAGGAGAAGTTCAAACAAATCCTCAAAGACACAGCCGGTTTAGGCACTCCAGCAACACGCGCAAGCA
TCATCCAGGGCGCTGTTGATAAAGGCTACTTCAAGCGTCAGAAAAAGGTACTGCTTGCAACTGATAAGGCTCATGCGCTT
ATAGCAGTGCTTCCACCAGCCATCAAATCACCCGGCATGACTGCGGCTTGGGAGCAGGAGCTTGAGAAAGTTGCCTCCGG
CTCCGGGAACATGTCTGTCTTCATGAAGCAGATTTCCACCTGGATCTGCCAAATGGTTGAGCAGCTCAAAGTGGCCGCAC
CGGTTCTGACCAAAGAAGGTGGCGCGATGGCTAAAGCCTTCGAGGGCGCGAAGCCTCCTTCACACGAATGCTTCAACTGC
GGTGGAGAGATGCACCGGATCAAAGGGAAGAACGGTTTTTTCTGGGGCTGCCAGAACGAGGCTTGCAAGAAGACGTTCCC
AGACAACCGAGGGAAACCCGAGAAACGTATCGCGGCGGAGGATTGTCCAGACTGCCCAGATTGCGGTAGCCCGATGCGTC
TCAGGAAAGGAAAAGCCCCTGGCAAGAAACGAGCCTCTAAGTTCTGGGGCTGCACAGCGTATCCCGATTGCAAAGGCACT
ATGCCCTTCAAAAAGTCGGACTTTATGGATTGA

Protein sequence :
MDLYICEKPSQAKDLAGVMKASQRGDGFLHDGGNRVITWAFGHLLELYMPDDYDERYKSWSLETLPIAPESWRYNVRKSA
FKQYKIVEGLVKKASTIYISTDYDREGEAIARSLLDRFRYSGPIRRVCLTALDESSIKKALNNVKDGKDTVSLYYAALAR
QRADWLVGMNVSRLYTVLARDVGFNHTLHVGRVITPTVALVCQRDREIAGFTPSPYWTLGVNVSVQNGQFAAQWIPPEEC
SDEQGRCVNKAYAEQVASQVNGANAVISKAETKPGKESAPLPFDLTSLQQYASKRWGYTAQQVLDAAQALYETHKATTYP
RTDSRYLPESQKEDIPDILQALILSDQNVSGLVAGADPHRKARVFNDAKVTAHHAIIPTPARTDISAMSEIEFNLYDAIR
RFYIAQFYSEFEFTKTSIEVQCGRHLFASAGKTPTKQGWKVLFASDSESSPKDEGEDTDAPVEQEKLPRVSQGEPALLNG
AELANKMTRPAPHFTEATLLAAMENIARFVTEEKFKQILKDTAGLGTPATRASIIQGAVDKGYFKRQKKVLLATDKAHAL
IAVLPPAIKSPGMTAAWEQELEKVASGSGNMSVFMKQISTWICQMVEQLKVAAPVLTKEGGAMAKAFEGAKPPSHECFNC
GGEMHRIKGKNGFFWGCQNEACKKTFPDNRGKPEKRIAAEDCPDCPDCGSPMRLRKGKAPGKKRASKFWGCTAYPDCKGT
MPFKKSDFMD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
PMI2630 YP_002152332.1 DNA topoisomerase III Not tested Not named Protein 5e-136 44
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 1e-140 43
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 4e-132 43
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 3e-130 43
topB AAN62194.1 putative DNA topoisomerase III Not tested PAGI-2(C) Protein 3e-140 42
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 4e-131 41
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 6e-131 41
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 6e-131 41