Gene Information

Name : merA (SNSL254_pSN254_0165)
Accession : YP_001102037.1
Strain :
Genome accession: NC_009140
Putative virulence/resistance : Resistance
Product : mercuric reductase
Function : -
COG functional category : C : Energy production and conversion
COG ID : COG1249
EC number : 1.16.1.1
Position : 145357 - 147042 bp
Length : 1686 bp
Strand : -
Note : identified by match to protein family HMM PF00070; match to protein family HMM PF00403; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR02053

DNA sequence : 
ATGACCCATCTAAAAATCACCGGCATGACCTGCGACTCGTGCGCGGCGCACGTCAAGGAAGCGCTGGAAAAAGTACCCGG
CGTCCAATCTGCCATAGTGTCCTATGCCAAGGGCGCGGCCCAGCTCGCCCTTGATCCAGGCACAGCGCCGGACGCACTGA
CCGCCGCCGTGGCTGGCCTGGGCTACAAAGCGATGCTCGCCGATGCCCCGCCGACCGACAACCGCACTGGGCTGTTCGAC
AAGGTGCGCGGCTGGATGGGTGCCGCCGACAAGGGCAGCGGCGGCGAGCGCCCGTTGCAAGTCGCCGTGATCGGCAGCGG
TGGAGCCGCGATGGCGGCAGCACTGAAGGCCGTCGAGCAAGGCGCGCAGGTCACGCTGATTGAGCGCGGCACCATCGGCG
GCACCTGCGTCAACGTCGGTTGTGTGCCGTCCAAGATCATGATCCGCGCCGCCCACATCGCCCATCTGCGCCGGGAAAGC
CCATTCGACGGCGGCATGCCACCCACACCGCCGACGATCTTGCGCGAGCGGCTGCTGGCCCAGCAGCAGGCCCGTGTCGA
AGAACTCCGTCATGCCAAGTACGAAGGCATCCTGGACGGCAATTCAGCCATCACCGTTCTGCACGGTGAAGCGCGTTTCA
AGGACGACCAGAGCCTTATCGTTAGTTTGAACGAGGGTGGTGAGCGCGTCGTGATGTTCGACCGCTGCCTGGTCGCCACG
GGTGCCAGTCCGGCCATGCCGCCGATTCCGGGCCTGAAAGAGTCACCCTACTGGACTTCGACCGAGGCCTTGGTCAGCGA
CACCATTCCCGAACGCCTAGCCGTGATCGGCTCGTCGGTGGTCGCGCTGGAACTGGCGCAAGCCTTCGCCCGGCTGGGCA
GCCAGGTCACGATCCTAGCTCGCAACACGCTGTTCTTCCGCGACGACCCGTCCATCGGCGAGGCCGTCACAGCGGCCTTC
CGTGCCGAAGGGATCAAGGTACTGGAACACACGCAAGCCAGCCAGGTCGCGCATGTGAACGGCGAATTCGTGCTGACCAC
GGGACACGGTGAAGTACGTGCCGACAAGCTGCTGGTCGCTACCGGACGGACACCGAACACGCGCAGCCTGGCACTCGACG
CGGCGGGAGTCACCGTCAATGCGCAGGGTGCCATCGTCATCGACAAGGGCATGCGCACCAGCACGCCACACATTTACGCG
GCCGGCGACTGCACGGACCAGCCACAATTCGTCTATGTGGCGGCAGCGGCCGGCACCCGTGCCGCGATCAACATGACCGG
AGGGGATGCTGCCATCAATCTAACCGCGATGCCGGCCGTGGTGTTCACCGATCCGCAAGTAGCAACCGTGGGCTACAGCG
AAGCGGAAGCGCATCACGACGGGATCGAAACCGACAGTCGCACGCTCACGCTCGACAACGTGCCGCGTGCGCTTGCCAAC
TTCGACACACGCGGCTTTATCAAGCTGGTCATCGAGGAAGGTAGCGGACGGCTCATCGGCGTGCAGGTCGTCGCCCCGGA
AGCCGGCGAATTGATCCAGACGGCTGTTCTCGCCATTCGCAACCGCATGACGGTGCAGGAACTGGCCGACCAGTTGTTCC
CCTACCTGACGATGGTCGAGGGGCTGAAGCTCGCGGCGCAGACCTTCACCAAGGATGTCAAACAATTGTCCTGCTGCGCA
GGATGA

Protein sequence : 
MTHLKITGMTCDSCAAHVKEALEKVPGVQSAIVSYAKGAAQLALDPGTAPDALTAAVAGLGYKAMLADAPPTDNRTGLFD
KVRGWMGAADKGSGGERPLQVAVIGSGGAAMAAALKAVEQGAQVTLIERGTIGGTCVNVGCVPSKIMIRAAHIAHLRRES
PFDGGMPPTPPTILRERLLAQQQARVEELRHAKYEGILDGNSAITVLHGEARFKDDQSLIVSLNEGGERVVMFDRCLVAT
GASPAMPPIPGLKESPYWTSTEALVSDTIPERLAVIGSSVVALELAQAFARLGSQVTILARNTLFFRDDPSIGEAVTAAF
RAEGIKVLEHTQASQVAHVNGEFVLTTGHGEVRADKLLVATGRTPNTRSLALDAAGVTVNAQGAIVIDKGMRTSTPHIYA
AGDCTDQPQFVYVAAAAGTRAAINMTGGDAAINLTAMPAVVFTDPQVATVGYSEAEAHHDGIETDSRTLTLDNVPRALAN
FDTRGFIKLVIEEGSGRLIGVQVVAPEAGELIQTAVLAIRNRMTVQELADQLFPYLTMVEGLKLAAQTFTKDVKQLSCCA
G

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
merA ACN81005.1 MerA Hg(II) mercuric ion reductase Not tested AbaR5 Protein 0.0 94
merA CAJ77060.1 Mercuric ion reductase Not tested AbaR1 Protein 0.0 94
merA ABQ57371.1 MerA Not tested SGI1 Protein 0.0 88
merA AGK07021.1 MerA Not tested SGI1 Protein 0.0 88
merA AGK07079.1 MerA Not tested SGI1 Protein 0.0 88
merA AET25397.1 MerA Not tested PAGI-2(C) Protein 0.0 85
merA AFG30120.1 MerA Not tested PAGI-2 Protein 0.0 85
merA YP_006098387.1 mercuric ion reductase Not tested Tn2411 Protein 0.0 85
merA AAN62178.1 mercuric (Hg(II)) reductase Not tested PAGI-2(C) Protein 0.0 80
unnamed ABR13401.1 mercuric reductase Not tested PAGI-5 Protein 0.0 77

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
merA YP_001102037.1 mercuric reductase BAC0652 Protein 0.0 91
merA YP_001102037.1 mercuric reductase BAC0653 Protein 0.0 80
merA YP_001102037.1 mercuric reductase BAC0650 Protein 3e-176 69