Gene Information

Name : HEAR0519 (HEAR0519)
Accession : YP_001098856.1
Strain : Herminiimonas arsenicoxydans
Genome accession: NC_009138
Putative virulence/resistance : Resistance
Product : metal-transporting P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 519965 - 522193 bp
Length : 2229 bp
Strand : +
Note : Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter

DNA sequence :
ATGGCTGAAATACATCGTCCTCAGAGTAAACAGGACATTGCGGATTGCTGCTCAATCGGCGATTGTCAGAGTTTATCCAA
TACTGCCACTCAGCCAGCTTCATCGGATGTGCCATCCAATGCACAGTCCGTCCAATACCGTATTTCCAATATGGATTGTC
CTGTCGAAGAAAAACTGATTCGTAACAAGCTGGAAGGCATGAACGGGGTTGTTCGTCTCGACTTTAACCTGATGAATCGC
ATCCTGAATGTTCACCATCGATTAAAGAGTCTGGAGTCTGTTACCACAGCACTGAAAGCCATCGGTATGGATGCGCAGCT
GGTTGATAGTGAAGCGCATCAGCCAAATGTTCAGGAATCAGCATCATTAACTGCAGCACAAAAGATACTACTGGCTGTTT
CCGGTGTCGCAGCACTGGCCGCGGAAGTTCTTGCCTGGACTACGCATAGCGATGGATCGCCTCTAGTCATTGCACTGGCC
TTTATTTCAATAGCAACCGGTGGATTGCCGACATTGAAAAAAGGCTGGATCGCGTTAAAGACATTCACGCTCAACATCAA
TTTCCTGATGAGTCTGGCAGTGATCGGCGCTATGGCAATAGGACAATGGCCCGAAGCTGCGATGGTGGTATTTCTTTTTG
CGGTCGCAGAACTAATTGAGAGTCTTTCTCTGAATCGTGCACGCAATGCTGTTCATGGGCTGTTGAAACTGGCTCCAGAT
GTCGTGTCCTTGCAGGACGCCAATGGTGGCTGGCAAGAAAAGCCCGTGGAATCTGCTGTTGTCGGTGACATGATGCGCGT
CAAGCCTGGTGAGCGTATCGCCCTCGATGGCGTCGTCACAAGTGGCGAGTCTTCTGTTAATCAGGCACCCATTACAGGTG
AGAGCATGCCGGTAGACAAACGCATGGGAGATTCTGTTTATGCGGGGAGTATCAATGAGCGTGGTTTGCTGGATATCAAG
GTATCCACCAGTAGCGGAAATAGCACCTTGGCAAAAATTGTTCGCGTCATTGAAGAGACGCAAAATAACAAGGCCGCGAC
CCAACGTTTTGTCGATACATTTGCTCGTTATTACACGCCTGCAGTAGTCGTCATGGCCATCCTTGTTGCCGTAATACCTC
CTTTAATATTCGGCGCAGAATTTACACCGTGGCTCTACAAGGCGTTGGTCATGCTCGTAATAGCCTGTCCATGTGCACTG
GTCATTTCTACGCCAGTAACCGTAGTGAGCGGTTTGACCGCTGCAGCAAGACTCGGAATTCTGATCAAGGGTGGAGAGTT
TCTTGAGGTCGGTTACAAGTTAAAGGCGATTGCACTGGACAAGACAGGTACTCTGACAGCCGGTCAGCCATCTGTAGTTG
ACGTGAAAACCGTAGGCAATAGTAATCGTGAAAGCATCTTGCTACTTGCGGCAAGTTTGGATGTGAACTCCGATCATCCT
TTGGCAAATGCAATCGTCAAAGCAGGCCCTGAAAGTTCTCAGCATAAAGTCGTTGCGAATTTTGAAGCATTGCCGGGGCG
TGGCGTGAAGGGAGAGATCGATGGCACGATTTACTATTTGGGAAATCATCGCCTGATCGAAGAATTGAAAGTTTGTAGCC
CAGCGATTGAAGCGCTTCTGGATGAAATAGAAGGTGCTGCGCAAACCGCTGTAATGCTCGCAACTGACAAAACGGTCGTG
GGTATTATTGCCGTTGCCGATAGCCTGCGCGAGAGTGCTATTGAAGGTGTTCGTCAACTGAATCAACTAGGCATAACCAC
CGTCATGCTGACCGGTGATAACAATCGCACAGCGCAGCAGATCGGTGCTCAGGTTGGTATTAATGTCATCAAGGCAGAAC
TACTGCCAGAAGACAAGTTGACCGAAATCAAAAGTCTTCAATCAAGCTATGGCGTAGTTGGGATGCTTGGTGACGGTATT
AACGATGCACCTGCATTGGCTCAAGCAAATGTTGGCTTCGCAATGGGCGCAGCAGGTAGCGATACCGCTATCGAAACCGC
AGACGTCGCTTTAATGAATGATGATCTTCGGAAACTTCCTGCTTTTATTAAATTAAGTCGAGCAACCCGCAGCATTTTGA
TTCAAAACATCACCGCAGCGATTGGTATTAAAGCAGTATTTTTTATCCTAGCTTTTATGGGAATAGCGACACTTTGGATG
GCTGTGTTTGCTGACGTTGGCGCGAGTCTCCTGGTAGTCTTCAATGGTTTGCGCTTGCTACGGAAATGA

Protein sequence :
MAEIHRPQSKQDIADCCSIGDCQSLSNTATQPASSDVPSNAQSVQYRISNMDCPVEEKLIRNKLEGMNGVVRLDFNLMNR
ILNVHHRLKSLESVTTALKAIGMDAQLVDSEAHQPNVQESASLTAAQKILLAVSGVAALAAEVLAWTTHSDGSPLVIALA
FISIATGGLPTLKKGWIALKTFTLNINFLMSLAVIGAMAIGQWPEAAMVVFLFAVAELIESLSLNRARNAVHGLLKLAPD
VVSLQDANGGWQEKPVESAVVGDMMRVKPGERIALDGVVTSGESSVNQAPITGESMPVDKRMGDSVYAGSINERGLLDIK
VSTSSGNSTLAKIVRVIEETQNNKAATQRFVDTFARYYTPAVVVMAILVAVIPPLIFGAEFTPWLYKALVMLVIACPCAL
VISTPVTVVSGLTAAARLGILIKGGEFLEVGYKLKAIALDKTGTLTAGQPSVVDVKTVGNSNRESILLLAASLDVNSDHP
LANAIVKAGPESSQHKVVANFEALPGRGVKGEIDGTIYYLGNHRLIEELKVCSPAIEALLDEIEGAAQTAVMLATDKTVV
GIIAVADSLRESAIEGVRQLNQLGITTVMLTGDNNRTAQQIGAQVGINVIKAELLPEDKLTEIKSLQSSYGVVGMLGDGI
NDAPALAQANVGFAMGAAGSDTAIETADVALMNDDLRKLPAFIKLSRATRSILIQNITAAIGIKAVFFILAFMGIATLWM
AVFADVGASLLVVFNGLRLLRK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 3e-175 56
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 2e-126 48
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 4e-126 48
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 4e-126 48

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HEAR0519 YP_001098856.1 metal-transporting P-type ATPase BAC0298 Protein 3e-173 56
HEAR0519 YP_001098856.1 metal-transporting P-type ATPase BAC0455 Protein 5e-97 43
HEAR0519 YP_001098856.1 metal-transporting P-type ATPase BAC0100 Protein 3e-67 41