Gene Information

Name : topB (HEAR1978)
Accession : YP_001100248.1
Strain : Herminiimonas arsenicoxydans
Genome accession: NC_009138
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 1991363 - 1993195 bp
Length : 1833 bp
Strand : +
Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2553698, 10574789; Product type e : enzyme

DNA sequence :
TTGCCCATCATTCCCCAGCATTGGCGGGTCGAGGTCAAACCGAAGACCGCCACGCAATTCAAGGTCGTCAAGGCGCTTCT
GGCGAAGGCGACCCAGCTTGTCATCGCCACCGATGCCGACCGCGAAGGCGAGTTGATCGCCCGCGAGATCATCGAACTGT
GCGGCTACCGCGGCCCCATCGAGCGGCTGTGGTTGTCGGCACTCAACGATGCGTCCATCCGCGCCGCCCTCGGCAAGCTA
CGGCCCTCAGCCGAGACGCTGCCGATGTACCACTCGGCGCTGGCGCGATCCCGTGCGGATTGGCTGGTGGGCATGAACCT
CAGTAGGTTGTTCACGGTGCTGGGGCGGCAGGCCGGCTACGACGGCGTGCTGTCGGTCGGCCGCGTCCAGACCCCGACGC
TCAAGCTCGTCGTGGACCGCGACCGCGAGATCGCAGCCTTCGTGTCCGTGCCGTACTGGGCCATCGTCGTGTCCCTGTCC
GCAGGTGTCCAGGCTTTCACCGCGCACTGGGTTCCACCCAATGCCTGCACCGACGACGCAGGCCGCTGCCTGCAGCAGCC
GGTCGCACAGCAGGCCATGCAGCAGATCCGCGCTGCGGGCAGCGCCCACGTAGTGTCGGTTGAGACCGAGCGCGTGCGCG
AAGGCCCGCCGCTGCCGTTCGACCTGGGCACCTTGCAGGAGGTGTGTTCAAAGCAGCTCGGGCTGGACGTGCAGGAAACC
TTGGAGATCGCCCAGGCCCTGTACGAGACGCACAAGGCCACGACATACCCCCGCTCGGATTCCGGCTACCTGCCCGAGAG
CATGTTTGCCGAAGTGACCACCGTTCTCGACAGCCTGCTTAAGACCGATCCCTCGCTGCGCTCGATCATAGGCCAGCTCG
ACCGTTTGCAGCGCTCGCGCGCCTGGAACGATGGCAAGGTCACGGCCCACCACGGCATCATCCCGACGCTCGAACCGGCG
AACCTCTCCGCCATGAGCGAGAAGGAACTGGCCGTGTACAGGCTCATCCGGGCGCATTACCTAGCGCAGTTCCTCCCTCA
CCACGAGTTCGACCATACTGTGGCCAAGCTTTCGTGCGGTGGGCAGAACCTTGCGGCCACGGGCAAGCAGGTTGTCACGC
CGGGCTGGCGCCAGGTGCTGGCCGAGCCGCAGTCCGAGGACGGCGATGGCGACGGCGACACCGCGGCCCGCGCCCAGGTG
CTACCGGCGCTGCACGAAGGTCTGGCATGTCAGGTGGCCGATATCGATCTGAAGGCACTCAAGACGCTGCCGCCCAAACC
GTACACGCAAGGCGAGTTGGTCAAGTCTATGAAAGGCGTCGCCAAGCTGGTGTCCGATCCCCGCCTGAAGCAGAAGCTCA
AGGATACGGTCGGCATCGGCACCGAAGCGACCCGGGCCAACATCATCGGCGGCCTGATCGCCCGCGGCTACCTCGTAAAG
AAAGGGCGCGCCATCCGCGCCTCGGATGCGGCTTTCACCTTGATCGATGCCGTGCCTGCGGCGATTGCCGACCCCGGCAC
CACCGCCGTCTGGGAACAAGCGCTCGACATGATCGAAGCCGGCCAGCTCACGCTGGATGTGTTCATCGGCAAGCAGGCCG
CATGGATTTCGCAGTTGATCGCGCAGTACGGCAACGCGTCCCTGTCTATCAAGGCTCCCCAAGGGCCGACATGCCCGCAG
TGCGGCGCACCCACGCGCCAGCGCAGCAGCAAGAGCGGCCCGTTTTGGTCGTGCAGTCGCTACCCGGACTGCAAAGGCAC
GCTGCCGGTCGAATCCGGCAGCTCCAAGCGCGCCGCCTCGCGCCCGCGCCGTAGCGGCCGCAAAGGCTCCTGA

Protein sequence :
MPIIPQHWRVEVKPKTATQFKVVKALLAKATQLVIATDADREGELIAREIIELCGYRGPIERLWLSALNDASIRAALGKL
RPSAETLPMYHSALARSRADWLVGMNLSRLFTVLGRQAGYDGVLSVGRVQTPTLKLVVDRDREIAAFVSVPYWAIVVSLS
AGVQAFTAHWVPPNACTDDAGRCLQQPVAQQAMQQIRAAGSAHVVSVETERVREGPPLPFDLGTLQEVCSKQLGLDVQET
LEIAQALYETHKATTYPRSDSGYLPESMFAEVTTVLDSLLKTDPSLRSIIGQLDRLQRSRAWNDGKVTAHHGIIPTLEPA
NLSAMSEKELAVYRLIRAHYLAQFLPHHEFDHTVAKLSCGGQNLAATGKQVVTPGWRQVLAEPQSEDGDGDGDTAARAQV
LPALHEGLACQVADIDLKALKTLPPKPYTQGELVKSMKGVAKLVSDPRLKQKLKDTVGIGTEATRANIIGGLIARGYLVK
KGRAIRASDAAFTLIDAVPAAIADPGTTAVWEQALDMIEAGQLTLDVFIGKQAAWISQLIAQYGNASLSIKAPQGPTCPQ
CGAPTRQRSSKSGPFWSCSRYPDCKGTLPVESGSSKRAASRPRRSGRKGS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB AAN62194.1 putative DNA topoisomerase III Not tested PAGI-2(C) Protein 0.0 95
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 0.0 75
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 0.0 63
PMI2630 YP_002152332.1 DNA topoisomerase III Not tested Not named Protein 2e-150 50
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 1e-145 49
topB NP_807836.1 DNA topoisomerase III Not tested SPI-7 Protein 1e-146 48
topB AAF14809.1 topoisomerase B Not tested SPI-7 Protein 7e-147 48
topB NP_458624.1 topoisomerase B Not tested SPI-7 Protein 1e-146 48