Gene Information

Name : HEAR1616 (HEAR1616)
Accession : YP_001099901.1
Strain : Herminiimonas arsenicoxydans
Genome accession: NC_009138
Putative virulence/resistance : Resistance
Product : toxic metal efflux pump
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 1610266 - 1612569 bp
Length : 2304 bp
Strand : -
Note : Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter

DNA sequence :
ATGCGGGCGAAAAAAACCCTTGACCCTATAGTGGCTACAGAGTCTCTAATTGCAAGTGTAAAACCAATTCAAACAGGAGT
ATCCATGCACTGTTGCGATCATGACCACGCCAACGCGGACAATCAGTCCGCTGTACCAGCATCTGCACCCGTTGCAGGTG
CAGAGCAGGTTGTGCTGCTGATCCAGAAGATGGATTGCCCGACCGAGGAAAAACTGATACGCGATCGCTTCCAGCACATG
GAAGGGATAGTCGGCATGCAGTTCAACCTGATGCAGCGCGAATTGACCGTACAGCACAATCTGATGTCGGTGGATGCCAT
CGTCACGGCATTGAAGAAACTCGATCTGGTCCCAATCGTGAAATCCGATACGCTGAATCTGGTGCGCGATGGCCTGGACG
AGCATCACGATCTGTCCGGCGATTACCGGATTTCACGCTCGAAATGGCTGTTGATGGGAATTTCCGGCGTGACGGCGATC
GGCTCGGAAATCGTGGCGTGGACTACCGGCGCAGATCATTCCTGGCCGGTGATCGCACTGGCGCTGCTGGCGATCCTGAC
GGGCGGCATGGATACGCTGAAAAAAGGCTGGATCGCCTTGCGCCATTTTTCTCTGAACATGAATTTCCTGATGTCGCTGG
CCGTCATGGGCGCCATCGCGATAGGAAAGTGGCCGGAAGCGGCGGTCGTAATCTTCCTGTTTGCGGCGGCTGAAATGATC
GAAGCGATGTCGCTCGATCGCGCCCGCAACGCGATCAAGGGGCTGATGGCGATGACGCCGGAGATCGCGACCGTGCGCAA
CAGTAGTGGCGAATGGCAAACCGTTGCCGCAGACCAGGTTGTTCTCGATGCCATCGTGCGCGTCAAACCGGGAGAACGTC
TGCCGCTGGATGGCATCATCGTCAACGGCCAAAGCACGATCAATCAGGCGCCTATCACCGGTGAAAGCATGCCGGTTGCA
AGGCAAATCGGCGATACGGTTTTTGCCGGCACCATCAACGAAATGGGTTCCTTCGACTACCGCGTCACCGCCTTGCAATC
CAATTCCACACTGGCGCGCATCATCAAGAGCGTGCAGCAGGTACAGGGCGAACGCGCACCGACGCAACGCTTTGTCGACC
AGTTTGCGCGCTATTACATTCCTGCCGTTGTCATCATGGCCGTGCTGGTTGCCTTGCTGCCGCCGCTGCTGATGCAGGCG
CCGTTTCAGCCCTGGCTGTACAAGGCACTGGTACTGCTGGTCATCGCCTGTCCGTGTGCGCTGGTGATTTCAACGCCTGT
TACCGTCGTCAGCGGACTGGCCGCCGCCGCACGACACGGCATCCTGATCAAGGGCGGCCTTTATCTTGAACTGGGATGCA
AACTGAAAGCGATTGCGCTCGACAAGACCGGCACCATCACGCTGGGCAAGCCGGTCGTGACCGATATGCTGGTGGTTGGT
GCAGGGGATGTCGACAATTTGCTGCGACTGGCTGCCAGCTTGTCGCAGCGCTCGGATCATCCGGTTTCATCGGCAGTCCT
GGCCTGGTGGAAGAGCCGGACATCTGTTCAGGCATTGTCCGAAGTCGCCGATTTTGAAGCGCTGACCGGGCGCGGCGTGA
AGGGTGCGATAGGTGGCGCATCGTACTACCTCGGCAATCACAGGCTGATTCATGAACTCGACATTTGCGGCCCCGAACTG
GAAGCGACGCTGGACGCCTTCGAGCGCAGCGGAAAAACAGCGATCATCCTGGCCTCCGAAACAGCGCCCTTGTTGATACT
GGTAGCGGCCGATACGGTGCGCGCCGGCAGCGCAGCTGCAGTGGCGAAGCTGAATGCGCTGGGGGTGAAAGTCGTGATGC
TGACCGGCGATAATCCGCATACGGCGGAAGCGATTGCCGCGCAGGTAGGGATTGCGGACGCGCGCGGCAATCAGCTGCCG
GACGACAAACTGGCCGCCATCAACGAACTGCTGGCTCAGCACGCTTGTGTCGGTATGGTCGGGGATGGCATCAATGACGC
GCCAGCACTGGCCAAAGCCAGCATCGGCTTTGCGATGGGGGCCGCCGGCACCGATACGGCGCTGGAAACCGCCGATGTTG
CATTGATGGACGACAACCTGGACAAACTCGCGGACTTCATCGGCCTGAGCAGCAAGACGCACACGATCCTGATCCAGAAT
ATCGCACTCGCGCTCGGCATCAAGGCTGTATTTCTGGTGCTCGCATTGTCAGGGGAGGCGACCTTGTGGATGGCCGTATT
CGCCGACATGGGCGCCAGCCTGATTGTCGTTGCCAATGGTTTGCGCCTGTTGCGTGCGATCTGA

Protein sequence :
MRAKKTLDPIVATESLIASVKPIQTGVSMHCCDHDHANADNQSAVPASAPVAGAEQVVLLIQKMDCPTEEKLIRDRFQHM
EGIVGMQFNLMQRELTVQHNLMSVDAIVTALKKLDLVPIVKSDTLNLVRDGLDEHHDLSGDYRISRSKWLLMGISGVTAI
GSEIVAWTTGADHSWPVIALALLAILTGGMDTLKKGWIALRHFSLNMNFLMSLAVMGAIAIGKWPEAAVVIFLFAAAEMI
EAMSLDRARNAIKGLMAMTPEIATVRNSSGEWQTVAADQVVLDAIVRVKPGERLPLDGIIVNGQSTINQAPITGESMPVA
RQIGDTVFAGTINEMGSFDYRVTALQSNSTLARIIKSVQQVQGERAPTQRFVDQFARYYIPAVVIMAVLVALLPPLLMQA
PFQPWLYKALVLLVIACPCALVISTPVTVVSGLAAAARHGILIKGGLYLELGCKLKAIALDKTGTITLGKPVVTDMLVVG
AGDVDNLLRLAASLSQRSDHPVSSAVLAWWKSRTSVQALSEVADFEALTGRGVKGAIGGASYYLGNHRLIHELDICGPEL
EATLDAFERSGKTAIILASETAPLLILVAADTVRAGSAAAVAKLNALGVKVVMLTGDNPHTAEAIAAQVGIADARGNQLP
DDKLAAINELLAQHACVGMVGDGINDAPALAKASIGFAMGAAGTDTALETADVALMDDNLDKLADFIGLSSKTHTILIQN
IALALGIKAVFLVLALSGEATLWMAVFADMGASLIVVANGLRLLRAI

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 4e-180 60
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 1e-115 47
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 1e-115 47
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 2e-114 46

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HEAR1616 YP_001099901.1 toxic metal efflux pump BAC0298 Protein 8e-175 59
HEAR1616 YP_001099901.1 toxic metal efflux pump BAC0461 Protein 3e-79 43