Gene Information

Name : HEAR1592 (HEAR1592)
Accession : YP_001099880.1
Strain : Herminiimonas arsenicoxydans
Genome accession: NC_009138
Putative virulence/resistance : Resistance
Product : cadmium-transporting ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : 3.6.3.3
Position : 1580779 - 1583013 bp
Length : 2235 bp
Strand : +
Note : Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter

DNA sequence :
ATGGCTGAAATACAACGCCCTCAAAATAAGCAAAGCATTTCGGATTGTTGCGAAGGCAGTAATTGCAGGACTTCATCTAA
TGCTGCCATTCAACCGTTTCCAGCGCCATTGGATGCTCCATCAAATGCTCAATCGGTCCAATACCGTATTTCAAATATGG
ATTGTCCCACAGAAGAAAAATTGATTCGGAACAAGCTGGAAGGCATGAATGGAATTATTCGTCTCGACTTTAACCTGATG
AACCGTATCCTGAGTGTTCACCATCAATTAAAGAGTCTGGAGTCCGTTACCACAGCACTGAAAGCCATCGGTATGGATGC
GCAGCTTGTTGATAGCGAAGCGCATCAGCCAAAGGTTCCGGAATCAGCGTCATTAACTGCAGCACAAAAGATCTTGCTGG
CTATTTCCGGTGTGGCAGCACTGGCCGCGGAAGTCCTTGCCTGGACTACTCATACCGATGGGTCGCCTCTAGTGATTGCA
CTGGCCTTTATTTCAATCGCAACAGGCGGATTGCCTACATTGAAAAAAGGCTGGATTGCGTTAAAGACATTCACCCTCAA
CATCAATTTTTTGATGAGTCTGGCGGTGATCGGTGCTATGGCAATCGGTCAATGGCCTGAAGCCGCAATGGTGGTATTTC
TCTTTGCGGTCGCAGAGCTGATCGAGAGTCTCTCGCTCAATCGTGCGCGCAATGCGGTGCATGGCTTGTTGAAACTGGCT
CCAGATGTCGTGACCTTGCAGGACGCCATTGGCGGATGGCAAGAAAAGTCCGTTGAAACGGCGGTTGTCGGCGACATGAT
GCGCGTCAAGCCTGGTGAGCGTATTGCCCTTGATGGGATTGTCACAAGTGGCGAGTCTTCGGTTAATCAGGCACCTATTA
CTGGTGAGAGCATGCCGGTGGACAAACGTATAGGGGATGCTGTCTACGCAGGAAGTATCAATGAGCGCGGCCTGCTCGAT
ATCAAGGTATCCACCAATAGCAGCAACAGCACCTTGGCGAGAATTGTTCGCGTCATCGAAGAGACGCAAAACAACAAGGC
CGCAACCCAACGTTTTGTTGATACGTTCGCTCGTTATTACACGCCTGCTGTTGTCGTCATGGCTATTCTGGTTGCCGTAA
TACCGCCTTTAGTATTCGGTGCGGAATTTACACCATGGCTTTACAAGGCTCTGGTCATGCTTGTAATCGCCTGTCCATGT
GCGCTAGTCATTTCGACGCCGGTAACAGTGGTGAGCGGTCTGACCGCCGCAGCAAGACTCGGCATTCTTATCAAGGGTGG
AGAGTTTCTTGAGGTGGGTTACAAGTTAAAAGCGATTGCGTTGGACAAGACAGGTACGCTGACAGCAGGTCAGCCATCTG
TTGTTGACGTGAAAACGATAAGCAATAACGAGCGAGAAACCATCTTGTTGCTTGCAGCAAGCCTGGATGCGAATTCAGAT
CATCCTTTGGCAAATGCCATCGTTAAAGCAGGTCCTGAGAGCTCACTGCATAAAGTCGTAACCAATTTCGAAGCCTTACC
CGGACGTGGCGTCAAAGGTGAGATCGACGGTACGATTTACTTTCTGGGAAATCACCGTCTGATCGAAGAGCTGAAGGTTT
GTAATCCAGCGATTGAAGCGTTGTTGGATGTAATTGAAGGTACTGCGCAAACCGCTGTAATGCTCGCCACGGAAAAAACG
GTCGTGGGTATTATCGCCATTGCCGATAGCTTGCGCGAGAGTGCTATCGAAAGTGTTCGTCAACTGAATCAACTAGGTAT
TACCACCGTCATGCTGACCGGTGATAACAATCGCACAGCGCAGCAGATCGGTGCTCATGTCGGTATTAGTGTCATCAAGG
CAGAACTGCTGCCAGAAGACAAGTTGACCGAAATCAAAAACCTTCAATCAACCTACGGCGTAGTTGGGATGCTCGGCGAT
GGTATAAACGATGCGCCAGCGTTGGCGCAAGCCGATGTTGGTTTCGCAATGGGTGCAGCAGGTAGCGATACGGCAATCGA
AACCGCTGATGTAGCATTGATGAATGATGACCTTGAGAAACTTCCGGTTTTTATCAAACTTAGTCGTGCTACCCGCAGCA
TTCTGATTCAAAACATCAGCGCAGCCATCGGTATTAAAGCAATATTTTTTGTCTTGGCTTTTATGGGAATAGCGACACTT
TGGATGGCTGTTTTTGCTGATGTGGGCGCGAGTCTCTTGGTAGTCTTCAACGGTTTGCGCTTACTGAGGAAATGA

Protein sequence :
MAEIQRPQNKQSISDCCEGSNCRTSSNAAIQPFPAPLDAPSNAQSVQYRISNMDCPTEEKLIRNKLEGMNGIIRLDFNLM
NRILSVHHQLKSLESVTTALKAIGMDAQLVDSEAHQPKVPESASLTAAQKILLAISGVAALAAEVLAWTTHTDGSPLVIA
LAFISIATGGLPTLKKGWIALKTFTLNINFLMSLAVIGAMAIGQWPEAAMVVFLFAVAELIESLSLNRARNAVHGLLKLA
PDVVTLQDAIGGWQEKSVETAVVGDMMRVKPGERIALDGIVTSGESSVNQAPITGESMPVDKRIGDAVYAGSINERGLLD
IKVSTNSSNSTLARIVRVIEETQNNKAATQRFVDTFARYYTPAVVVMAILVAVIPPLVFGAEFTPWLYKALVMLVIACPC
ALVISTPVTVVSGLTAAARLGILIKGGEFLEVGYKLKAIALDKTGTLTAGQPSVVDVKTISNNERETILLLAASLDANSD
HPLANAIVKAGPESSLHKVVTNFEALPGRGVKGEIDGTIYFLGNHRLIEELKVCNPAIEALLDVIEGTAQTAVMLATEKT
VVGIIAIADSLRESAIESVRQLNQLGITTVMLTGDNNRTAQQIGAHVGISVIKAELLPEDKLTEIKNLQSTYGVVGMLGD
GINDAPALAQADVGFAMGAAGSDTAIETADVALMNDDLEKLPVFIKLSRATRSILIQNISAAIGIKAIFFVLAFMGIATL
WMAVFADVGASLLVVFNGLRLLRK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ORF C97 AAN62190.1 putative metal-transporting P-type ATPase Not tested PAGI-2(C) Protein 4e-173 56
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 2e-122 46
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 5e-125 43
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 4e-125 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
HEAR1592 YP_001099880.1 cadmium-transporting ATPase BAC0298 Protein 4e-172 56
HEAR1592 YP_001099880.1 cadmium-transporting ATPase BAC0100 Protein 1e-65 41