Gene Information

Name : guaA (P9301_00361)
Accession : YP_001090260.1
Strain : Prochlorococcus marinus MIT 9301
Genome accession: NC_009091
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 34859 - 36445 bp
Length : 1587 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAGTCAAAAATCTTTCAAAAAAGAACGAGATCCTTCAATATTAATTTTAGATTTCGGATCTCAATATTCTGAATTGAT
TGCAAGACGAATTAGAGAAACTAATGTTTTTTCTCTTGTAGTTAGTAATTGTATTTCAATTGAAGACATCAATGATATAA
ATCCTAAAGGGATTATTTTAAGTGGAGGCCCGAACTCTGTATATGAACAAAATGCTCCGAAATGTGATAAAAAAATTTTT
AATTTAGGAATTCCTATTCTTGGCATTTGCTATGGAATGCAATTAATGGTCAAAGAACTTGGAGGGTCAGTTATTTCAGC
AACTAAAAAAGCTGAATATGGAAGAGCACCAATAAATATAGATCAAGAATCTGACCTCCTTCGTGATGTAGAAGATAAAT
CTATAATGTGGATGAGTCATGGCGATTCAATTAATTGTTTGCCTGATGGATTTAATAAAATTGCTCATACTGAGAACACA
CTCCATGCAGCAATTTCAAATGATATAAAGAAATTATTTGGCGTACAATTTCATCCTGAAGTTGTACATTCAGAGTTTGG
GATGAAGATAATTAAAAATTTTGTTTATAACATTTCTTGTTGTGAGGCTGATTGGACAACTGAAACCTACATAGAGGAAA
CTATTCCTAGGATAAGAGAGCAAGTTGGCAATAAAAAAGTTTTGCTTGCCTTGTCAGGAGGAGTTGATTCCTCGACCCTT
GCTTTTCTTCTTAATAAAGCAATTGGAAATCAGCTTACATGCATGTTTATTGACCAAGGTTTCATGAGAAAAGGCGAACC
AGAATTTTTAATGAATTTTTTTGATAAGAAATTTCACATTAAAGTTGAATATATTAACGCAAGGGAAAGGTTTATTGCCA
AATTAAAAGGGATTACTGATCCAGAACAAAAAAGGAAAATTATTGGTGAAGAATTTATTAGAGTATTTGAAGAAGAAAGT
AATAGATTGGGACCTTTTCAGTACTTAGCTCAAGGTACTCTTTATCCTGATGTTATTGAAAGTGCTGGTACTAATATTGA
TCCCAAGACTGGTGAAAGAATAGCTGTAAAAATAAAGAGTCATCATAACGTGGGTGGATTGCCAAAAGATTTACAATTTA
AATTAGTTGAGCCATTAAGAAAACTTTTTAAGGATGAAGTCAGAAAAGTCGGCGGTGCCTTAGGTTTACCGGATGAGATT
ATAAAAAGGCATCCATTCCCAGGCCCGGGATTAGCTATAAGAATTTTGGGCGAGGTGAATAATGAAAAGCTTGATTGTTT
AAGAGATGCAGACTGGATAGTAAGAGATGAAATTAAAAAAGCTGGTCTTTACAACGATATTTGGCAAGCTTTTGCAGTAT
TGCTACCGGTTAAAACTGTAGGAGTTATGGGAGATAAAAGGACTTATGCATGGCCAATAGTTTTACGTTGCGTATCTAGT
GAAGATGGCATGACAGCAGATTGGTCAAAAATTCCTTTTAAGATTTTGGAGAGGATTGCAAATAGAATCGTAAATGAAGT
AATTTCAGTAAATAGAGTTGTATATGATATCACGAGCAAACCTCCTGGAACTATTGAATGGGAATGA

Protein sequence :
MSQKSFKKERDPSILILDFGSQYSELIARRIRETNVFSLVVSNCISIEDINDINPKGIILSGGPNSVYEQNAPKCDKKIF
NLGIPILGICYGMQLMVKELGGSVISATKKAEYGRAPINIDQESDLLRDVEDKSIMWMSHGDSINCLPDGFNKIAHTENT
LHAAISNDIKKLFGVQFHPEVVHSEFGMKIIKNFVYNISCCEADWTTETYIEETIPRIREQVGNKKVLLALSGGVDSSTL
AFLLNKAIGNQLTCMFIDQGFMRKGEPEFLMNFFDKKFHIKVEYINARERFIAKLKGITDPEQKRKIIGEEFIRVFEEES
NRLGPFQYLAQGTLYPDVIESAGTNIDPKTGERIAVKIKSHHNVGGLPKDLQFKLVEPLRKLFKDEVRKVGGALGLPDEI
IKRHPFPGPGLAIRILGEVNNEKLDCLRDADWIVRDEIKKAGLYNDIWQAFAVLLPVKTVGVMGDKRTYAWPIVLRCVSS
EDGMTADWSKIPFKILERIANRIVNEVISVNRVVYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-139 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-139 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-139 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-129 50