Gene Information

Name : tetM (CD630_05080)
Accession : YP_001086983.1
Strain : Clostridium difficile 630
Genome accession: NC_009089
Putative virulence/resistance : Resistance
Product : Tetracycline resistance protein Tn5397
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0480
EC number : -
Position : 600034 - 601953 bp
Length : 1920 bp
Strand : +
Note : Evidence 1a : Function experimentally demonstrated in the studied strain; PubMedId : 12568329,12568327,17650959, 11157942, 11073898, 8863741; Product type f : factor

DNA sequence :
ATGAAAATTATTAATATAGGTGTTTTAGCTCATGTTGACGCAGGAAAAACTACTTTGACAGAAAGCTTACTATATACTAG
TGGAGCGATTGCGGAGTCAGGAAGCGTGGATACAGGCACAACAAGAACGGATACTACATTTTTAGAACGTCAGCGAGGAA
TTACAATTCAGACAGCAGTAACCTCTTTTCAGTGGAAAGATATTAAGGTAAATATCATAGATACTCCAGGACATATGGAT
TTTTTAGCAGAAGTATATCGCTCGTTATCAGTTTTAGATGGGGCAATCCTACTAATTTCTGCGAGAGATGGAGTACAAGC
ACAAACTCGGATATTATTTCATGCACTAAATAAAATGGGTATTCCCACAATCTTTTTTATCAATAAGATTGACCAAAATG
GGATTGATTTATCAACGGTTTATCAAGATATTAAAGAGAAACTTTCTATGGAAATTATAATCAAACAGAAAGTAGAGCTG
CACCCTAATATGTGTGTGATGAGCTGTACGGAACCTGAGCAATGGGATGTGGTAATAGAAGGAAATGATTATCTTTTGGA
GAAATATACACTTGGGAAATCATTGGAGATATTAGAACTCGAACAAGAGGAAATCAGAAGATTTCAGAATTGCTCCTTGT
ACCCTGTTTATCATGGAAGCGCAAAAAGCAACATAGGGATTGAGCAGCTTATAGAAGTGATAACGAATAAATTTTATTCA
TCAACATACAGAAAGAAGTCTGAACTTTGCGGAAATGTCTTCAAAATTGAATATTCGGAAGAAAGACAACGTCTTGCATA
TGTACGCCTTTATGGCGGAATCCTGCATTTGCGGGATTCGGTTAGAATATCGGAAAAGGAAAAAATAAAAATTACAGAAA
TGTATACTTCAATAAATGGTGAATTATGTAAAATTGATAAGGCTTATTCCGGGGAAATTGTTATTTTGCAAAATGAGTTT
TTGAAGCTAAATAGTGTTCTTGGAGATACAAAGCTATTGCCACAGAGAGAGAGAATTGAAAATCCGCTCCCTCTGCTGCA
AACAACTGTTGAACCGAGCAAACCTCAACAAAGGGAAATGTTACTTGATGCACTTTTAGAAATCTCCGACAGTGACCCGC
TTCTACAATATTATGTGGATTCTACGACACATGAAATCATACTTTCTTTCTTAGGGAAAGTACAAATGGAAGTGACTTGT
GCTCTATTGCAAGAAAAGTATCATGTGGAGGTAAAAATAAAAAAGCCTACAGTCATTTATATGGAAAGACCGTTAAAAAA
AGCAGAGTATACCATTCACATCGAAGTGCCACCGAATCCCTTCTGGGCTTCCATTGGTCTTTCTGTAGCACCGCTTCCAT
TAGGGAGCGGAGTACAGTATGAGAGCTCGGTTTCTCTTGGATACTTAAATCAATCGTTTCAAAATGCAGTTATGGAAGGG
ATACGATATGGCTGTGAACAAGGATTGTATGGTTGGAATGTGACGGACTGTAAAATCTGTTTTAAGTATGGCTTATACTA
TAGCCCTGTTAGTACCCCAGCAGATTTTCGGATGCTTGCTCCTATTGTATTGGAACAAGTTTTAAAAAAAGCTGGAACAG
AATTGTTAGAGCCATATCTTAGTTTTAAAATTTATGCACCACAAGAATATCTTTCACGAGCATATAACGATGCTCCTAAA
TATTGTGCGAACATCGTAGACACTCAACTGAAAAATAATGAGGTCATTCTTAGTGGAGAAATTCCTGCTCGGTGTATTCA
AGAATATCGTAATGATTTAACTTTCTTTACAAATGGACGTAGCGTTTGTTTAACAGAGTTAAAAGGGTACTATGTTACTA
CTGGTGAATCTGTTTGTCAGCCCCGTCGTCCAAATAGTCGGATAGATAAAGTACGATATATGTTCAATAAAATAACTTAG

Protein sequence :
MKIINIGVLAHVDAGKTTLTESLLYTSGAIAESGSVDTGTTRTDTTFLERQRGITIQTAVTSFQWKDIKVNIIDTPGHMD
FLAEVYRSLSVLDGAILLISARDGVQAQTRILFHALNKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSMEIIIKQKVEL
HPNMCVMSCTEPEQWDVVIEGNDYLLEKYTLGKSLEILELEQEEIRRFQNCSLYPVYHGSAKSNIGIEQLIEVITNKFYS
STYRKKSELCGNVFKIEYSEERQRLAYVRLYGGILHLRDSVRISEKEKIKITEMYTSINGELCKIDKAYSGEIVILQNEF
LKLNSVLGDTKLLPQRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLQYYVDSTTHEIILSFLGKVQMEVTC
ALLQEKYHVEVKIKKPTVIYMERPLKKAEYTIHIEVPPNPFWASIGLSVAPLPLGSGVQYESSVSLGYLNQSFQNAVMEG
IRYGCEQGLYGWNVTDCKICFKYGLYYSPVSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYNDAPK
YCANIVDTQLKNNEVILSGEIPARCIQEYRNDLTFFTNGRSVCLTELKGYYVTTGESVCQPRRPNSRIDKVRYMFNKIT

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SSU05_0922 YP_001198287.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 96
SSU98_0928 YP_001200485.1 translation elongation factor (GTPases) Not tested 89K Protein 0.0 96
tetO AFJ97266.1 truncated tetracycline resistant protein Not tested Not named Protein 8e-155 75
tet(W) YP_005160006.1 tetracycline resistance protein Not tested Not named Protein 0.0 69

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 AM180355.1.gene636.p Protein 0.0 100
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 X04388.gene.p01 Protein 0.0 93
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 M85225.gene.p01 Protein 0.0 91
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 NC_009782.5559075.p0 Protein 0.0 89
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 NC_002758.1120355.p0 Protein 0.0 89
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 L09756.gene.p01 Protein 0.0 80
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 AJ295238.gene.p01 Protein 0.0 73
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 AY485126.gene.p01 Protein 0.0 69
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 AJ222769.gene.p01 Protein 0.0 69
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 DQ294299.gene.p01 Protein 0.0 68
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 FN594949.1.gene24.p0 Protein 0.0 68
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 L42544.gene.p01 Protein 4e-123 44
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 AJ514254.gene.p01 Protein 2e-117 43
tetM YP_001086983.1 Tetracycline resistance protein Tn5397 Z21523.gene.p01 Protein 2e-103 41