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Name : CD630_04210 (CD630_04210) Accession : YP_001086889.1 Strain : Clostridium difficile 630 Genome accession: NC_009089 Putative virulence/resistance : Unknown Product : DNA topoisomerase protein, type IA,Tn1549-like,CTn2-Orf16 Function : - COG functional category : L : Replication, recombination and repair COG ID : COG0550 EC number : 5.99.1.2 Position : 493445 - 495151 bp Length : 1707 bp Strand : + Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15673722, 7773745, 12568329, 12568327,17650959, 11157942,11073898, 8863741; Product type e : enzyme DNA sequence : ATGAAGTTAGTTATTGCAGAAAAGCCGAGTGTTGCAATCTCCATTGCAAAGGTTATTGGAGTAAATAAAAAGAAAGACGG ATATTATGAAGGAAACGGATATAGGGTGAGCTGGTGCGTTGGACACCTAATTCAAATGGCAAATCCGGATGCTTATGATG AAAAGTACGCCAAGTGGAATATGGCTGATTTACCGATTATTCCGAGCGCCTACAAGTATGAAGTAGCAAAGGCAACCAAG AAGCAGTTTAACATCCTTAAAAAGCTGATGAATGATAAAGAGATTGATACGGTTATCAACGCTTGTGATGCAGGTCGTGA AGGAGAAAGCATTTTTAGATTGGTATATAACGAAGCTAAATGCAAAAAGAAGATGAAACGCCTTTGGATTTCATCTATGG AGGATAGTGCCATTAAAGAGGGCTTTGATAATCTAAAAGACGGAAAGGGCTATGACAATCTCTTTGAATCGGCACAGGCA AGAGCGATTGCAGATTGGCTTGTCGGAATGAACATCAGCAGGCTCTATTCTTGCCTATATAAGCAAAATTACAGTGTAGG AAGAGTGCAGACACCGACTCTTGCCATGATTGTAAAAAGAGATGATGAGATAGCTAATTTCAAGAAAGAGAAATACTATA CAGTGGAGCTATCTATGAATGGTTTTACACTATCAACGGATAGAATTGATGATGAGGTTGCTGCCGAACAGCTAATCAAT TTAGTTGGCGATAAGATTGAAATCACTGATGTTATTCAGAAAGAGAAAATAACAAATCCTGATTTACCTTTTGACCTGAC AACACTTCAAAGGGAATGCAATAAGTATTTCGGATATAGTGCCAAGCAGACACTTGACTATGCTCAAAGCCTGTATGAAA AGAAACTGATTACTTATCCAAGAACGGACAGCAGGTGTTTAACAGAGGATATGATTACAAGTACCATCAATAACATTTTG GGCAAAAATGACTTTGATACAGGGCGCATCAAGACGGTATTTAACTCTAAAAAGGTTACGGATCACCACGCTATTATTCC GACAATCAGTTCATTAAAGGAAGATGTTTCTAAGCTTCCTCTAAGCGAAGCTAAAGTTTACTTTCTTATATCCGATAAAT TTCACGCAAGTGTAGGTTATCCACTTATTGAAAATACAACAAAGATTGTAGCTTCATTTGACGGTTTTGAATTTACAAGT TCAGGCAAGGTAATTAAGGATGAAGGCTTTAGCAAATACCTTAAAGAATACAAATCAAAAAAGAATGAAGATGCTGTACT TCCTAATGTAAGTGTTGGTGATGTTTTAAGCATTGAAAATAAAGAGATTAAAGAAAAATTTACCAAACCTCCAAAACACT TTACGGAAGATACTCTCTTAAAGTCTATGGAGATTGCGGGAAATGATGCCTTAGAAAAAGGTGTAGAAGTGGAAAGAAAA GGACTTGGAACACCTGCAACAAGGGCAGGGATTATCGAAAATCTAATTTATAAGGGATTTGTAGAAAGAGATAAGAAAAA TCTTATAGCCACTCATAAAGGAATTAGCCTTGTAACGATTGTAGCGGATAACTTTAAGTCGGCAGAAACGACAGCGAAGT GGGAAATGGAATTATCTGATATTGCTCAGGGTAAATCATCTAAGAAAGAATTTTTAGATGCGATTGAAAATGAGATAAAA GAAGCGGTTTTGACATATCGCAAGTAA Protein sequence : MKLVIAEKPSVAISIAKVIGVNKKKDGYYEGNGYRVSWCVGHLIQMANPDAYDEKYAKWNMADLPIIPSAYKYEVAKATK KQFNILKKLMNDKEIDTVINACDAGREGESIFRLVYNEAKCKKKMKRLWISSMEDSAIKEGFDNLKDGKGYDNLFESAQA RAIADWLVGMNISRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYYTVELSMNGFTLSTDRIDDEVAAEQLIN LVGDKIEITDVIQKEKITNPDLPFDLTTLQRECNKYFGYSAKQTLDYAQSLYEKKLITYPRTDSRCLTEDMITSTINNIL GKNDFDTGRIKTVFNSKKVTDHHAIIPTISSLKEDVSKLPLSEAKVYFLISDKFHASVGYPLIENTTKIVASFDGFEFTS SGKVIKDEGFSKYLKEYKSKKNEDAVLPNVSVGDVLSIENKEIKEKFTKPPKHFTEDTLLKSMEIAGNDALEKGVEVERK GLGTPATRAGIIENLIYKGFVERDKKNLIATHKGISLVTIVADNFKSAETTAKWEMELSDIAQGKSSKKEFLDAIENEIK EAVLTYRK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| EFAU085_00720 | YP_008394244.1 | DNA topoisomerase III | Not tested | Not named | Protein | 3e-121 | 47 |
| topB-2 | NP_815968.1 | DNA topoisomerase III | Not tested | Not named | Protein | 7e-128 | 46 |
