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Name : CD630_18590 (CD630_18590) Accession : YP_001088366.1 Strain : Clostridium difficile 630 Genome accession: NC_009089 Putative virulence/resistance : Unknown Product : DNA topoisomerase protein, type IA,Tn1549-like,CTn5-Orf16 Function : - COG functional category : L : Replication, recombination and repair COG ID : COG0550 EC number : - Position : 2151738 - 2153444 bp Length : 1707 bp Strand : + Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12568329, 12568327, 17650959, 11157942,11073898, 8863741; Product type e : enzyme DNA sequence : ATGAAACTTGTAATAGCAGAAAAGCCAAGTGTTGCAATTTCTATTGCTAAAGTAATTGGAGCAACAAAAAAGAAAGACGG ATATTATGAGGGAAATGGATACAAGGTAAGTTGGTGTGTTGGACACTTAATTCAGATGGCAAATCCGGAAAGTTACGATG AAAAGTACGCTAAATGGAATATGGCGGATTTACCGATTATTCCAAGAGAATATAAGTATGAGATTGCAAAGTCCACAAAG AAACAATTTACGATTCTTAAAAAGTTGATGAATGACAAGGAAATAGACATTGTGATAAATGCTTGCGATGCAGGACGTGA AGGAGAAGCAATCTTCAGGCTTGTCTATAATCAGGCAAATTGCAAAAAGAAGATGAAACGCCTTTGGATTTCATCAATGG AAGATAGTGCAATTAAAGAGGGCTTTGATAACCTAAAAGACGGAAGTTTTTACGATAATCTCTTTGAATCTGCACAAGCA AGAGCTATTGCGGATTGGCTTGTGGGAATGAATTTAAGTAGGCTATACTCGTGCCTATATAAGCAGAATTATTCTGTTGG CAGAGTACAAACACCAACTCTTGCCATGATTGTAAAAAGAGATGATGAAATAGCAAATTTCAAGAAAGAAAAATATTTTA CAGTAGAGCTTGATTTAGACGGCTTTTCTCTTTCTACCGATAGAATTGATGATAAGACAGTTACAGAGCAGCTTATCAAT CTATTAGGTAATTCCATAGAAATTACCGATGTTATTCAAAAGGAAAAGATAACAAAACCTGAGCTGCCATTTGACCTTAC AACGCTTCAAAGAGAGTGTAATAAGTATTTCAATTATAGTGCAAAGCAGACCTTAGATTATACACAAAGTTTATACGAGA AAAAACTGATTACCTATCCAAGAACGGACAGTCGTTATCTTACAGAAGATATGATTACAAGTACAATCAACAATATTGTT GGAAAGCATGATTTTGATACAGGTCGCATTAAGATGGTATTTAATTCTAAAAGGGTTACAGACCATCATGCGATTATACC GACAGCAAGCAGTATGAATGAGGACTTAGCTTCACTTCCGGAAAGTGAATTGAAGGTATATGAACTTGTTTTAAATAAGC TACATGCAAGTGTAGGCTATCCTTTAATTGAGAATACTACAAAGATTGTAGCTGTATTTGACGGATTTGAATTTACAAGC AGTGGAAAGGTGATTGTAGATGAGGGCTTTACCAAATACCTAAAAAAATATATAAAAAAGAAAAATGAAGATACCGTGTT TCCGGATTTAAAGATTGGTGATAGTCTTGATATTAAGGAGAAAGAGATAAAAGAAAACTACACATCACCGGCTAAACATT TTACGGAAGATACACTTTTAAAGGATATGGAGCTTGCAGGAAATGACGCACTGGAAAAAGGTGTAGAAGTTGAGCGAAAA GGACTTGGAACACCTGCAACAAGAGCAGGCATTATTGAAAATTTAATCTTTAAGGGTTTTGTAGAAAGAGATAAGAAAAA CCTTATTGCTACACACAAAGGAATAAGCCTTGTAACGATTGTCTCAGATACTTTTAAATCAGCAGGTACAACCGCTAAGT GGGAAATGGAGTTATCGGATATTGCACAAGGCAAAGCTTCAAAGGAAAATTTTTTAAAAGCGATTGAAAACGAGATAAAA GAATTGGTTTCAACTTATAGCAAGTAA Protein sequence : MKLVIAEKPSVAISIAKVIGATKKKDGYYEGNGYKVSWCVGHLIQMANPESYDEKYAKWNMADLPIIPREYKYEIAKSTK KQFTILKKLMNDKEIDIVINACDAGREGEAIFRLVYNQANCKKKMKRLWISSMEDSAIKEGFDNLKDGSFYDNLFESAQA RAIADWLVGMNLSRLYSCLYKQNYSVGRVQTPTLAMIVKRDDEIANFKKEKYFTVELDLDGFSLSTDRIDDKTVTEQLIN LLGNSIEITDVIQKEKITKPELPFDLTTLQRECNKYFNYSAKQTLDYTQSLYEKKLITYPRTDSRYLTEDMITSTINNIV GKHDFDTGRIKMVFNSKRVTDHHAIIPTASSMNEDLASLPESELKVYELVLNKLHASVGYPLIENTTKIVAVFDGFEFTS SGKVIVDEGFTKYLKKYIKKKNEDTVFPDLKIGDSLDIKEKEIKENYTSPAKHFTEDTLLKDMELAGNDALEKGVEVERK GLGTPATRAGIIENLIFKGFVERDKKNLIATHKGISLVTIVSDTFKSAGTTAKWEMELSDIAQGKASKENFLKAIENEIK ELVSTYSK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| topB-2 | NP_815968.1 | DNA topoisomerase III | Not tested | Not named | Protein | 6e-129 | 47 |
| EFAU085_00720 | YP_008394244.1 | DNA topoisomerase III | Not tested | Not named | Protein | 3e-120 | 46 |
