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Name : vanG (CD630_16260) Accession : YP_001088127.1 Strain : Clostridium difficile 630 Genome accession: NC_009089 Putative virulence/resistance : Resistance Product : D-alanyl-alanine synthetase A Function : - COG functional category : M : Cell wall/membrane/envelope biogenesis COG ID : COG1181 EC number : 6.3.2.4 Position : 1884003 - 1885103 bp Length : 1101 bp Strand : + Note : Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14617152, 16723588; Product type e : enzyme DNA sequence : ATGAATAATAAAAAAATTGCAGTTATATTTGGTGGAAACTCAACAGAATATGATGTATCATTACAATCAGCTTTTGCAGT ACTTGAGAATTTGAATACGGAAAAATATGATATTCTACCAATTGGAATTACAAGGGAGGGTAATTGGTATCATTATATTG GAGATTATAATAATATCCAGAATAACACTTGGTTTGAAAGGGATACTGATATAATTCCAGTTATTGTTTCGCAGAACCGT GTCAAAAATGGTATTATTGAATTTTTAATTTCTGATGCTGTTTCTCAGAATCATATTCCAAATAGTGCTATTGAATCATG TGAAAATGATATTAAATACACTAAACTTGATTTTGTATTTCCTGTATTGCATGGAAAAAATGGAGAAGATGGAACAGTGC AGGGGTTATTTGAATTGGCAGGTATACAGGTTATTGGATGTGGTACTCTTTCTTCAGCATTATGTATGGACAAAGACAAA TCACATAAACTTGTTCATTCAGAAGGTATTAAAGTACCAAAATCAATATTACTAAAATACTCAGATAAATTTAATGTGGC TGAACTGTCAAAAGACTTAACTTATCCATTATTTATAAAACCTGTGCGTGCAGGTTCATCATTTGGTATTAGTAAAATTT ATAAAAAAGAAGAGTTACAAGTAGCAGTAGACTTGGCTTTTGAACATGATAATGAAGTAATAATTGAGGAAAATATTGAT GGTTTTGAGGTAGGGTGTGCAGTTTTAGGAAACAATGACTTACTTGTTGGAAGAGTAGATGAAATAGAATTGTCAAAAGG ATTTTTTGATTATACAGAAAAATATACATTGAAAAGTTCAAAAATTCATATGCCAGCTAGAATTGATTTGGATTGTGAGA AAAGAATACAAGAGACAGCAAAAATTATTTATAGAACTCTTGGATGTTCTGGATTTGCTAGAGTAGATATGTTTTTAACT CCATCTGGTGAAATTATTTTTAATGAAGTCAATACAATTCCTGGCTTTACTTCTCATAGTCGTTATCCAAATATGATGAA AGGTATTGGACTGTCTTTTGAAGAAATATTGGACAAGATAATTGAGGTGTACATAAAATGA Protein sequence : MNNKKIAVIFGGNSTEYDVSLQSAFAVLENLNTEKYDILPIGITREGNWYHYIGDYNNIQNNTWFERDTDIIPVIVSQNR VKNGIIEFLISDAVSQNHIPNSAIESCENDIKYTKLDFVFPVLHGKNGEDGTVQGLFELAGIQVIGCGTLSSALCMDKDK SHKLVHSEGIKVPKSILLKYSDKFNVAELSKDLTYPLFIKPVRAGSSFGISKIYKKEELQVAVDLAFEHDNEVIIEENID GFEVGCAVLGNNDLLVGRVDEIELSKGFFDYTEKYTLKSSKIHMPARIDLDCEKRIQETAKIIYRTLGCSGFARVDMFLT PSGEIIFNEVNTIPGFTSHSRYPNMMKGIGLSFEEILDKIIEVYIK |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| vanB | YP_008394259.1 | Vancomycin B-type resistance protein vanB, D-alanine--D-lactate ligase | Not tested | Not named | Protein | 7e-60 | 43 |
| vanB | NP_815951.1 | D-alanine--D-lactate ligase | Not tested | Not named | Protein | 2e-60 | 43 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | AY145441.gene.p01 | Protein | 4e-61 | 43 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | AF310956.2.orf5.gene | Protein | 4e-61 | 43 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | AE016830.1.gene2250. | Protein | 1e-60 | 43 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | U00456.gene.p01 | Protein | 1e-60 | 43 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | U35369.1.gene6.p01 | Protein | 1e-60 | 43 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | AF277571.gene.p01 | Protein | 1e-58 | 43 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | AF130997.1.orf4.gene | Protein | 7e-58 | 42 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | AY489045.gene.p01 | Protein | 4e-57 | 42 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | AF162694.gene.p01 | Protein | 9e-66 | 42 |
| vanG | YP_001088127.1 | D-alanyl-alanine synthetase A | L29638.gene.p01 | Protein | 2e-60 | 41 |
