Gene Information

Name : entE (A1S_2381)
Accession : YP_001085402.1
Strain : Acinetobacter baumannii ATCC 17978
Genome accession: NC_009085
Putative virulence/resistance : Virulence
Product : enterobactin synthase subunit E
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 2.7.7.58
Position : 2756605 - 2758146 bp
Length : 1542 bp
Strand : -
Note : bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate

DNA sequence : 
TTGACGCGCATTTTAACGGTAGGGGTTCAATCGCATCCGCATTCGCCGGCAATTATTTGTGGTGAGCGTCAGTTGAGTTA
TATCGAGCTGGACCAGCTATCAACAAATTTAGCTTCTCGACTAGCTGAAAAAGGCTTGGGCAAGGGTGATACAGCTTTAG
TACAGCTTCCCAATGTTGCAGAGTTTTATATTGTCTTTTTTGCCTTGCTTAAGGCAGGCGTGGTTGTGCTCAATGCGCTA
TATAGTCATCGCCAATATGAACTAAATGCCTTTATTAAACAGATTCAACCTAAGCTTTTAATTGGTTCACGTCAGCATGA
AGTCTTTAGCAATAATCAATTTATTGACTCACTTCATGAAGTAAATTTAAGTCCTGAAATTATTTTGATGCTCAATCATC
AAGCTACCGATTTCGGTCTATTAGACTGGATTGAAACACCAGCAGAGACCTTTGTCGATTTTTCATCTACACCTGCTGAT
GAAGTTGCTTTCTTTCAGTTGTCAGGTGGAAGTACGGGAACACCAAAACTTATTCCAAGAACGCATAATGACTACGACTA
TAGTGTGCGGGCCAGTGCCGAGATTTGCGGTTTAAACTCGAATACTCGGTTATTGTGTGCTCTGCCAGCTCCGCATAACT
TTATGTTGAGTTCACCCGGTGCATTAGGTGTTTTACATGCAGGTGGATGTGTTGTGATGGCACCAAATCCTGAACCGCTC
AATTGTTTTTCTATTATTCAAAGACATCAAGTCAATATGGCATCTTTAGTGCCGAGTGCTGTCATTATGTGGCTAGAAAA
AGCCGCGCAATATAAAGATCAAATTCAGTCTTTAAAGTTGCTTCAAGTAGGTGGAGCAAGTTTCCCTGAATCTTTAGCTC
GTCAAGTTCCTGAAGTCCTCAATTGTAAATTACAACAAGTATTTGGAATGGCTGAAGGCTTGGTCAATTACACCAGACTC
GATGACTCCGATGAGCAAATATTTACGACACAAGGGTGTCCTATCAGTTCTGATGATGAAATCAAAATTGTGGATGAACA
GTATAAAGAGGTTCCAGAAGGTGAAATAGGGATGCTTGCGACTCGGGGACCTTATACCTTCTGTGGTTATTACCAAAGCC
CTGAACATAATTCACAGGTCTTTGATGAGGACAACTATTACTATTCGGGCGATCTCGTGCAGCGTACCCCTGATGGTAAT
TTACGTGTAGTAGGAAGAATTAAAGACCAGATTAACCGTGGTGGTGAAAAGATTGCTTCGGAAGAAATAGAAAAACTTAT
TCTTTTACATCCGGAAGTTATACACGCAGCTTTGGTCGCAATTGTTGATGAACAATTTGGTGAAAAGAGTTGTGCCTTTA
TTGTTTCTCGTAATCCTGAACTTAAAGCTGTTGTGCTCAGACGCCATCTCATGGAGTTAGGTATTGCACAATACAAACTT
CCAGACCAGATCAAATTAATCGAAAGTTTGCCACTGACCGCAGTCGGTAAGGTGGACAAAAAACAACTTCGCAGCATTTT
AAATACATTTACAACATCTTAA

Protein sequence : 
MTRILTVGVQSHPHSPAIICGERQLSYIELDQLSTNLASRLAEKGLGKGDTALVQLPNVAEFYIVFFALLKAGVVVLNAL
YSHRQYELNAFIKQIQPKLLIGSRQHEVFSNNQFIDSLHEVNLSPEIILMLNHQATDFGLLDWIETPAETFVDFSSTPAD
EVAFFQLSGGSTGTPKLIPRTHNDYDYSVRASAEICGLNSNTRLLCALPAPHNFMLSSPGALGVLHAGGCVVMAPNPEPL
NCFSIIQRHQVNMASLVPSAVIMWLEKAAQYKDQIQSLKLLQVGGASFPESLARQVPEVLNCKLQQVFGMAEGLVNYTRL
DDSDEQIFTTQGCPISSDDEIKIVDEQYKEVPEGEIGMLATRGPYTFCGYYQSPEHNSQVFDEDNYYYSGDLVQRTPDGN
LRVVGRIKDQINRGGEKIASEEIEKLILLHPEVIHAALVAIVDEQFGEKSCAFIVSRNPELKAVVLRRHLMELGIAQYKL
PDQIKLIESLPLTAVGKVDKKQLRSILNTFTTS

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 6e-82 41
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 3e-81 41
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 5e-82 41
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-81 41
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-82 41
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 6e-82 41
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-82 41
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 6e-82 41
ybtE CAA21394.1 - Virulence HPI Protein 6e-82 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
entE YP_001085402.1 enterobactin synthase subunit E VFG0932 Protein 7e-134 57
entE YP_001085402.1 enterobactin synthase subunit E VFG0168 Protein 7e-100 43