Gene Information

Name : guaA (A1S_0130)
Accession : YP_001083217.1
Strain : Acinetobacter baumannii ATCC 17978
Genome accession: NC_009085
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 155476 - 156933 bp
Length : 1458 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTATGCCTTTGATATGTCTGAAGAAGACATCCGTGCTTTTAAGCCAAACGGTATCATTTTATCAGGTGGACCTGAGAG
TGTGCATGAAGAGGGCAGCCCTCGCGCACCGCAAGTGGTGTTTGAATTAGGCGTTCCAGTATTGGGTATTTGCTATGGTT
TACAAACCATGTCTGAACAGTTAGGCGGTAAAGTTGAGCCGGGTACTGTACATGAGTTTGGTTATGCCGAAGTTGATATC
GTTAAACGTGACCAACTCATTGGCAACTTACAAGACCGCGAAAACCAACTACACGTTTGGATGAGCCACGGCGACAAAGT
GAGCCAGATTCCAGAAGGTTTTACGATTACTGCAAGCACACCAAGCTGTCCAGTTGCTGCTGTAAGTGATGAAACACGCC
GTTTTTACGGTGTTCAGTTCCACCCAGAAGTAACACACACGGCAAAAGGTGAAGAGCTACTTTCTAATTTCGTTCACAAA
ATTTGTGGATGCGGTGGCCTTTGGACACCTGAACACATCATCGATTTGCGTGTAGAGCAGTTACGTGAGCAAATTGGTAA
CGAGAAAGTACTTTTAGGCCTGTCTGGTGGTGTTGACTCATCTGTTGTTGCTGCGCTTTTACACAAAGCGATTGGTGACC
AATTAACATGTGTATTTGTTGATAATGGTTTGCTTCGTTTAAACGAAGGTGACCAAGTGATGCAAATGTTTGCTGAAAAC
ATGGGTATTCGTGTTATTCGTGCGGATGCAGAAGCGCGCTTCTTAAATGCTCTAGCTGGCGTTACCGATCCTGAAGCGAA
GCGTAAAATTATTGGTCGTGAGTTCATTGAAGTATTTGCTGAAGAAGCACGTAAACTTGATGGCGTGAAATTCTTGGCGC
AAGGTACAATTTACCCAGACGTAATTGAATCTGCTGCAAGCAAACAAGGTAAAGCACACGTTATTAAATCTCACCACAAT
GTGGGTGGTTTACCAGACGATTTAGCATTTGAACTGGTTGAGCCTTTACGTGACTTGTTTAAAGATGAAGTACGTAAATT
AGGTACTACACTTGGTTTACCGCACAGCATGATCTACCGTCATCCATTCCCAGGCCCAGGTTTAGGCGTTCGTATTTTGG
GTGAAGTGAAAAAAGAATATGCAGATATTCTTCGTCTTGCTGATGATATCTTTATGCAAGAGCTTCGTGACAGTGGCTGG
TATGACAAAACAGCTCAAGCATTTGCTGTATTCCAACCTGTTAAATCAGTAGGTGTAGTCGGTGATGGCCGTCGCTATGC
ATGGGTGATTGCACTTCGTGCAGTTGAAACAGTTGACTTTATGACAGCTCGTTTTGCACATTTACCATACGAATTGGTTG
ATAAAATCTCAACACGTATTATGAACGAAATTAAAGATGTATCACGTGTGGTATACGACGTGTCATCTAAACCACCAGCA
ACGATTGAGTGGGAATAA

Protein sequence :
MYAFDMSEEDIRAFKPNGIILSGGPESVHEEGSPRAPQVVFELGVPVLGICYGLQTMSEQLGGKVEPGTVHEFGYAEVDI
VKRDQLIGNLQDRENQLHVWMSHGDKVSQIPEGFTITASTPSCPVAAVSDETRRFYGVQFHPEVTHTAKGEELLSNFVHK
ICGCGGLWTPEHIIDLRVEQLREQIGNEKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLNEGDQVMQMFAEN
MGIRVIRADAEARFLNALAGVTDPEAKRKIIGREFIEVFAEEARKLDGVKFLAQGTIYPDVIESAASKQGKAHVIKSHHN
VGGLPDDLAFELVEPLRDLFKDEVRKLGTTLGLPHSMIYRHPFPGPGLGVRILGEVKKEYADILRLADDIFMQELRDSGW
YDKTAQAFAVFQPVKSVGVVGDGRRYAWVIALRAVETVDFMTARFAHLPYELVDKISTRIMNEIKDVSRVVYDVSSKPPA
TIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 5e-130 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-130 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 4e-130 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-105 50