Gene Information

Name : guaA (Mjls_1200)
Accession : YP_001069494.1
Strain : Mycobacterium sp. JLS
Genome accession: NC_009077
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1276374 - 1277933 bp
Length : 1560 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
GTGAATTCCCCATCCCCGCGGCCCGTCCTGGTGGTCGACTTCGGCGCGCAGTATGCGCAGCTGATCGCGCGTCGGGTCCG
CGAAGCCCGGGTCTTCTCCGAGGTCGTCCCGCACACCGCCACCGTCGAGGAGATCAAGGCGAAGGACCCGCAGGCGATCG
TGCTGTCCGGCGGTCCGGCGAGCGTCTACGCCGACGGCGCCCCGCAGCTCGACCCGGCGCTGTTCGACCTCGACGTCCCG
GTGTTCGGCATCTGCTACGGCTTTCAGGCCATGGCGCAGGCGCTCGGTGGCACGGTCACGCACACCGGCACCAGGGAGTA
CGGCCGCACCGAGCTGAAAGTGGCTGGGGGAGAGCTTCATTCGGACCTGCCCGCCGTCCAGCCGGTGTGGATGAGCCACG
GTGACGCGGTCACCGAGGCGCCGTCCGGTTTCGAGGTGGTGGCGACCAGCGCCGGTGCGCCGGTCGCGGCCTTCGAGAAC
CGGGCCCGCCGCCTCGCCGGGGTGCAGTACCACCCCGAGGTGCTGCACTCCCCGCACGGCCAGCAGGTGCTCAGCCGGTT
CCTGCACGAGTTCGCCGGTATCGGCGCCAAATGGACCCCGGCCAACATCGCCGATGCGCTCGTCGAGCAGGTGCGCGAGC
AGATCGGTGACGGTCGCGCCATCTGCGGGCTGTCGGGCGGGGTGGACTCCGCGGTGGCGGCCGCGCTGGTGCAGCGCGCC
ATCGGCGACCGGCTGACCTGTGTGTTCGTCGACCACGGACTGCTGCGCTCGGGGGAGCGGGCACAGGTGCAGCGCGATTT
CGTCGCCGCCACGGGCGCCAATCTGGTCACCGTCGACGTCGCCGACCGCTTCCTCCAGGAACTGTCCGGGGTGACCAACC
CCGAGGGCAAGCGCAAGATCATCGGCCGCGAATTCATCAGCGCCTTCGACGATGCGGTGGTCGACATCGTGGGCGACAGC
GGAGCGCCGGTCGAATTCCTGGTGCAGGGGACCCTCTACCCCGACGTCGTCGAATCCGGCGGCGGCTCGGGTACGGCGAA
CATCAAGAGCCACCACAACGTGGGCGGCCTGCCCGCCGACCTGAAGTTCAAACTCGTCGAACCGCTGCGGCTGCTGTTCA
AGGACGAGGTGCGAGCGGTCGGACGTGAACTCGGGCTGCCCGAGGACATCGTTGCGCGCCAACCCTTCCCGGGTCCGGGG
CTGGGGATCCGCATCGTCGGTGAGGTGACGCGCGGGCGGTTGGAGACGCTGCGGCACGCCGATGCGATCGCCCGTGAGGA
GCTCACCGCCGCGGGTCTGGACAACCAGATCTGGCAGTGCCCGGTGGTGCTGCTGGCCGATGTCCGGTCGGTGGGGGTGC
AGGGCGACGGCCGTACCTACGGCCATCCGATCGTGCTGCGGCCGGTGTCCAGCGAGGACGCCATGACCGCCGACTGGACG
CGGGTGCCCTACGAGGTGCTCGAGCGGATCTCCACCCGCATCACCAACGAGGTGCCCGAGGTGAACCGGGTCGTGCTCGA
CGTCACGAGCAAGCCGCCCGGCACCATCGAGTGGGAATAG

Protein sequence :
MNSPSPRPVLVVDFGAQYAQLIARRVREARVFSEVVPHTATVEEIKAKDPQAIVLSGGPASVYADGAPQLDPALFDLDVP
VFGICYGFQAMAQALGGTVTHTGTREYGRTELKVAGGELHSDLPAVQPVWMSHGDAVTEAPSGFEVVATSAGAPVAAFEN
RARRLAGVQYHPEVLHSPHGQQVLSRFLHEFAGIGAKWTPANIADALVEQVREQIGDGRAICGLSGGVDSAVAAALVQRA
IGDRLTCVFVDHGLLRSGERAQVQRDFVAATGANLVTVDVADRFLQELSGVTNPEGKRKIIGREFISAFDDAVVDIVGDS
GAPVEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPADLKFKLVEPLRLLFKDEVRAVGRELGLPEDIVARQPFPGPG
LGIRIVGEVTRGRLETLRHADAIAREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWT
RVPYEVLERISTRITNEVPEVNRVVLDVTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 0.0 78
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 8e-138 52
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-137 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-138 52