Gene Information

Name : dhbE (BURPS668_A0874)
Accession : YP_001061873.1
Strain :
Genome accession: NC_009075
Putative virulence/resistance : Virulence
Product : 2,3-dihydroxybenzoate-AMP ligase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : 6.3.2.-
Position : 848201 - 849844 bp
Length : 1644 bp
Strand : -
Note : identified by match to protein family HMM PF00501

DNA sequence : 
TTGCCCGCCGCCGCGCGCAACGCCGCGTCGAGCGACGCGCCCGACTGGCCCGACGACTTCGCGCGCCGCTACCGCGACGC
CGGCTACTGGCGAGACGAGACCTTCTACGGCGCGCTCGCCGAGCGCGCGCGGCGCAGCCCCACCGCGACCGCGGTCGTCG
ACGGCGAGCGCCGCGTCAGCTACCGCGCGCTGCTCGAGCGCATCCGGCGTCTCGCCGGCGGCTTGCGCCGCCTGGGCCTC
GCGCGCGGCGACACGGCCGTCGTGCATCTGCCGAACGGCGTGCGCTTCATCGAAGCGTGCTTCGCGCTGTTCCAGCTCGG
CGTGCGCCCGGTGCTCGCGCTGCCCGCGCATCGGCAACACGAGATCGGCGCGTTCTGCCGCTTCACGAATGCCCGCGCAT
ATCTCGGCGCGGCCCGGCTCGGCGAGTTCGACTGCCGCCCGCTCGCTCACGCGCTGCGGGCGAGCTGCCCGGCGCTCGCG
CACATCGTCGTCGCGGGCGACGATCATGCCTTCTTGCATTTCGATTCGCTGTACGACACGCCGCCCGTCGCCGACTGCGC
GGCGCGCGCGGACGACATCGCGTGCTTCCAGCTCTCGGGCGGCACGACGGGCACGCCGAAACTGATTCCGCGCCGCCATC
GCGAGTACCTGTACAACGTGCGCGCGTGCTCGGACGCGAGCGGCTTCGGCGCCGACACCGTCTATCTGGCCGCGCTGCCG
ATGGCGCACAACTTCACGCTGTGCTGCCCCGGCGTGATCGGCGCGCTGCTCGCGGGCGGCCGCGTCGTCGCGACCGAGCA
CCCCGAGCCGGAGTGCGGCTTTGCGCTGATCGCGCGCGAGCGGGTCACGCATACGGCGCTCGTCCCGCCGCTCGCGCTAC
TGTGGCTGGACGCGCAGCGCGAGCGCCGAGCGGACCTGTCGAGCCTGCGCGTGCTGCAGGTCGGCGGCGCGCGGCTGATG
GACCACGCGGCCGAACGCGTGACGCCCGTCCTCGGCTGCCGGCTGCAACAGGTATTCGGAATGGCCGAAGGCCTCATCTG
CTGCACGCGGCTCGACGATCCGCCCGCGCGCATCGCGCGTACGCAGGGCCGGCCGGTGTCGCCCGCCGACGAAGTGCGCA
TCGTCGACGAGGCGGGCCGCGCCGTCGCGCCTGGCGAGATCGGCGAATTGCAGGTGCGCGGGCCCTATACGATCCGCGGC
TACTACCGGCTCGCCGAGCATCATGCGGCCGCGTTCACGGCCGACGGCTTCTATCGCACCGGCGACCGCGTGCGCCGCAC
CGAAGAAGGCGACCTCGTCGTCGAGGGCCGCGACAAGGACCAGATCAATCGCGGCGGCGAAAAAGTATCCGCCGAGGAAG
TCGAGAACCTGCTGCTCGCGCATTCGCAAATCCGCGACGCGGCGCTCGTCGCGATGTCCGATCCGCTGCTCGGCGAGCGC
ACGTGCGCGTTCGTCGTCGCGCGCCCGCCCGCGCCGACCTCGCTCGCGCTGAAACGGCATTTGCGCGACCACGGGCTCGC
CGCGTTCAAGATTCCCGATCGCATCGAATTCGTGCCGAGCTTTCCGGAAACCGGCATCGGCAAGACCAGCAAGAAATCGC
TGCGCGACCTGCTGCGCCGCCGGCTCGAAGCGGCGCGCGCATGA

Protein sequence : 
MPAAARNAASSDAPDWPDDFARRYRDAGYWRDETFYGALAERARRSPTATAVVDGERRVSYRALLERIRRLAGGLRRLGL
ARGDTAVVHLPNGVRFIEACFALFQLGVRPVLALPAHRQHEIGAFCRFTNARAYLGAARLGEFDCRPLAHALRASCPALA
HIVVAGDDHAFLHFDSLYDTPPVADCAARADDIACFQLSGGTTGTPKLIPRRHREYLYNVRACSDASGFGADTVYLAALP
MAHNFTLCCPGVIGALLAGGRVVATEHPEPECGFALIARERVTHTALVPPLALLWLDAQRERRADLSSLRVLQVGGARLM
DHAAERVTPVLGCRLQQVFGMAEGLICCTRLDDPPARIARTQGRPVSPADEVRIVDEAGRAVAPGEIGELQVRGPYTIRG
YYRLAEHHAAAFTADGFYRTGDRVRRTEEGDLVVEGRDKDQINRGGEKVSAEEVENLLLAHSQIRDAALVAMSDPLLGER
TCAFVVARPPAPTSLALKRHLRDHGLAAFKIPDRIEFVPSFPETGIGKTSKKSLRDLLRRRLEAARA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ybtE CAA21394.1 - Virulence HPI Protein 3e-100 50
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 2e-100 50
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 3e-100 50
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-100 50
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 3e-100 50
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-100 50
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-100 50
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 2e-99 49
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 3e-99 49
irp2E YP_005163485.1 siderophore biosynthetic protein Virulence Not named Protein 4e-59 41
irp2E YP_005134497.1 siderophore biosynthetic protein Virulence Not named Protein 3e-59 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
dhbE YP_001061873.1 2,3-dihydroxybenzoate-AMP ligase VFG0168 Protein 3e-162 69
dhbE YP_001061873.1 2,3-dihydroxybenzoate-AMP ligase VFG0932 Protein 3e-96 45
dhbE YP_001061873.1 2,3-dihydroxybenzoate-AMP ligase VFG1817 Protein 1e-87 45