Gene Information

Name : guaA (BURPS668_2402)
Accession : YP_001059434.1
Strain :
Genome accession: NC_009074
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2367604 - 2369223 bp
Length : 1620 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCACGACAAAATCCTGATTCTCGACTTCGGTTCGCAAGTCACTCAACTGATCGCGCGGCGCGTCCGCGAAGCGCACGT
CTACTGCGAGATCCATCCGAACGACGTTTCCGACGACTTCGTTCGCGAGTTCGCCCCGAAGGGCGTGATTCTGTCCGGCA
GCCACGCGAGCACCTACGAGGACCACCAGTTGCGCGCGCCGCAGGCGGTATGGGATCTCGGCGTGCCCGTGCTCGGCATT
TGCTACGGGATGCAGACGATGGCCGTGCAACTGGGCGGCAAGGTCGAATGGAGCGACCACCGCGAGTTCGGCTATGCGGA
AGTGCGCGCGCATGGCCGCACGCGCCTGCTCGACGGCATCCAGGATTTCGCGACGCCCGAAGGCCACGGGATGCTGAAGG
TCTGGATGAGCCACGGCGACAAGGTCGGCGAGATGCCGCCGGGCTTCGCGCTGATGGCGTCGACGCCGAGCTGCCCGATC
GCCGGCATGGCCGACGAGGCGCGCGGCTACTACGCGGTGCAGTTCCACCCGGAAGTCACGCACACGGTGCAGGGCCGCAA
GCTGCTCGAGCGCTTCGTGCTCGACATCGCCGGCGCGAAACCCGACTGGATCATGCGCGACCACATCGAGGAGGCGGTCG
CGCGGATTCGCGAGCAGGTCGGCGACGAGGAAGTGATCCTCGGCCTGTCGGGCGGCGTGGATTCGAGCGTCGCGGCGGCG
CTCATCCACCGTGCGATCGGCGATCAATTGACTTGCGTGTTCGTCGACCACGGCCTGCTGCGCCTGAACGAAGGCAAGAT
GGTGCTCGACATGTTCGAAGGCCGGCTGCATGCGAAGGTCGTCCACGTCGACGCGTCCGAGCAGTTCCTCGGCCATCTCG
CGGGCGTCGCCGATCCGGAGCACAAGCGCAAGATCATCGGCCGCGAGTTCGTCGAAGTGTTCCAGGCGGAAGCGAAGAAG
CTGACGAACGCGAAGTGGCTCGCGCAGGGGACGATCTACCCGGACGTGATCGAATCGGGCGGCGCGAAGACGAAGAAGGC
GACGACGATCAAGAGCCATCACAACGTGGGCGGCTTGCCGGAGACGCTCGGCCTGAAGCTGCTCGAGCCGCTGCGCGATC
TGTTCAAGGACGAAGTGCGCGAGCTTGGCGTCGCGCTCGGCTTGCCGGCGGAGATGGTGTATCGCCATCCGTTCCCGGGC
CCGGGCCTCGGCGTGCGGATTCTGGGCGAAGTGAAGCGCGACTACGCGGAGCTGCTGCGCCGCGCGGATGCGATCTTCAT
CGAAGAGCTCCGCGGGACGCTCGCGACCGAGCAGGATGCGGCGGCGGGCCTGTGCGAGCCGTCGCAGGTCGGCAAGAGCT
GGTACGACCTGACGAGCCAGGCGTTCGCGGTGTTCCTGCCGGTGAAGTCGGTCGGCGTGATGGGCGACGGCCGCACGTAC
GACTACGTGGCCGCGCTGCGCGCGGTGCAGACGACCGATTTCATGACGGCGCATTGGGCGCATCTGCCGTATGCGCTGCT
CGGCCGCGCGTCGAACCGGATCATCAACGAAGTGCGCGGGATCAATCGGGTGGTGTACGACGTGTCGGGTAAGCCGCCGG
CGACAATCGAGTGGGAGTGA

Protein sequence :
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGRTRLLDGIQDFATPEGHGMLKVWMSHGDKVGEMPPGFALMASTPSCPI
AGMADEARGYYAVQFHPEVTHTVQGRKLLERFVLDIAGAKPDWIMRDHIEEAVARIREQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASEQFLGHLAGVADPEHKRKIIGREFVEVFQAEAKK
LTNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPAEMVYRHPFPG
PGLGVRILGEVKRDYAELLRRADAIFIEELRGTLATEQDAAAGLCEPSQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVAALRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-118 49
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-118 49
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-118 49
guaA NP_938969.1 GMP synthase Not tested Not named Protein 3e-106 47