Gene Information

Name : nanK (APL_1753)
Accession : YP_001054442.1
Strain : Actinobacillus pleuropneumoniae L20
Genome accession: NC_009053
Putative virulence/resistance : Virulence
Product : N-acetylmannosamine kinase
Function : -
COG functional category : K : Transcription
COG ID : COG1940
EC number : 2.7.1.60
Position : 1990190 - 1991062 bp
Length : 873 bp
Strand : +
Note : catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein

DNA sequence : 
ATGCGTTGTTTAGCATTAGATATCGGCGGTACTAAGATTGCCTCGGCATTAGTCGAAAACGGAGTGATTTCCCAACGCCG
ACAAATCGGCACACCGCAACAAGATGCGGCGGAAGCAATGCATCAAACGTTGGCGGACATTTTGCAACAGTACCAAGGGC
AGTTTGGTGCGGTATCGGTAGCTTCGACCGGTATTATTAATAACGGCGTTTTAACCGCATTAAACCCGAAGAATTTAGGC
GGGTTGGCTTTTTTCCCGTTGCAAGAAAGTATTGCACGTCATACCGATAAACCGATTTTCTTACTCAATGACGTACAAGC
GGCGGCTTGTGCCGAATATCAACATCAAGATAAACAAGCGGTCGAAAATTTCGTCTTTATTACCGTTTCAACCGGGGTTG
GCGGCGGCATTATCCAAAATGGCAAATTGCTAACCCAACCGAATGGTGTAGCAGGACATATCGGGCATACTTTAGCGGAT
CCGAACGGGCCAATTTGTGGCTGTGGTCGCCGAGGTTGTGTGGAAGCGATTGCTTCCGGGCGAGCGATTGAAGCGGTTTC
AAGCCGATGGACGGAACCTTGTACACCGAAACAAGTGTTTGAGCAATTCCGAGCGGGCAAAGTGCAAGCGGTCGAATTAG
TCGAAAAATCTGCAAAAGCCATTGCCAATTTAGTGGCGGATTTAACCATCGGTTTAGATACGCAAAAAGTGGTGATCGGC
GGCAGTGTCGGCTTGGCGGAAGGTTATTTACCGCTCGTGCAAAAATATTTAGCCGAAATGCCGCATTTCTATCATTGTGA
ATTGGAAGCGGCGAAATATGGCGGCGATGCCGGTTTAATCGGTGCGGCAGCATGGGCGGAACAACATTTTTAA

Protein sequence : 
MRCLALDIGGTKIASALVENGVISQRRQIGTPQQDAAEAMHQTLADILQQYQGQFGAVSVASTGIINNGVLTALNPKNLG
GLAFFPLQESIARHTDKPIFLLNDVQAAACAEYQHQDKQAVENFVFITVSTGVGGGIIQNGKLLTQPNGVAGHIGHTLAD
PNGPICGCGRRGCVEAIASGRAIEAVSSRWTEPCTPKQVFEQFRAGKVQAVELVEKSAKAIANLVADLTIGLDTQKVVIG
GSVGLAEGYLPLVQKYLAEMPHFYHCELEAAKYGGDAGLIGAAAWAEQHF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
nanK YP_002414055.1 N-acetylmannosamine kinase Not tested Not named Protein 2e-35 43
VC1782 NP_231417.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 1e-30 42
VC0395_A1379 YP_001217322.1 N-acetylmannosamine kinase Not tested VPI-2 Protein 1e-30 42
VPI2_0030 ACA01847.1 ROK family protein Not tested VPI-2 Protein 6e-30 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
nanK YP_001054442.1 N-acetylmannosamine kinase VFG1115 Protein 6e-31 42