Gene Information

Name : murD (APL_0016)
Accession : YP_001052729.1
Strain : Actinobacillus pleuropneumoniae L20
Genome accession: NC_009053
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : 6.3.2.9
Position : 18128 - 19438 bp
Length : 1311 bp
Strand : +
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGCAAAACCAATATAAAGATAAAGTCATTACGGTTATCGGCTTAGGTAAAACAGGTTTATCTTGTGTCGAATTTTTGGC
GGATAAGCAAGCAAAAGTACAAGTGATTGATACCCGCGAAAAGCCGGCGGGTGCCGATCAGCTTCCGGCAGATGTACCGT
TGCATACCGGCGGTTTAAACAGCGAGTGGCTGTTAGCCTCCGATTTAATTGTAATTAGTCCGGGGCTTGCGTTGGCTACA
CCGGAAATTCAACAAGCGATCAACGCCGGTATGGAAGTGGTTGGCGATATCGAATTATTTGTACGTGAGGCGAAAGCGCC
GATTATTGCGATTACCGGTGCAAACGGCAAAAGCACGGTGACGACCTTAGTGACCGAAATGGCAAAACAGGCGGGGATTA
AAGTCGGTATGGGCGGCAATATCGGAGTGCCGGTATTAAGCCTGTTAAACGATGAATATGAATTGTTTGTGTTGGAACTG
TCTAGTTTCCAATTAGAAACCACTTCGTCATTAAATGCGGTGGCAGCAACTATTTTAAATATTAGTGAAGATCATATGGA
TCGTTACAATAACTCGCTGGAAGAATATCGTTTAGCGAAATTGCGTATTTATGACAATGCCGAGAATGTGATTGTAAACG
GTGAAGATAGACTGACTTATCCGCTTGAAACGCAAGCGGTCAAAAAATTGATTCGTTTTGCAGAACATAACGCCGAATAT
ACGATGCGTAACGGCATTTTATATTCGGGCGATGATGCGATTATCCCAACTAAAGAAATGCTGATTTCAGGTCGTCATAA
CGAAATGAATTCATTAGCGGCAATGGCGTTAGCCGAAGCGGCGGGCATTCCGCGTGAAGGAATTGTCAAAGCATTGCAAG
TGTACGGCGGTTTGAATCACCGTTTCCAAGCGGTCAAGACCAATGACGGCGTGCGTTGGGTAAACGACTCAAAAGCAACC
AATGTCGGCAGTACGGTAGCGGCACTCAACGGTTTACAAGTAGCGGGAACGCTTTATTTGTTATTAGGGGGTGACGGTAA
AGCCGCTGATTTTTCCGAGTTAAAACCGCTTATCAATAAACCGAATATCGTTTGTTATTGCTTCGGTCAGGACGGTGCGC
AATTAGCCGCATTATCAAGCCAAAGCGTATTGGTGGAGACTATGCAACAAGCGATTGAACAAATCCGCCCGCAATTGAAA
AAAGGCGATATGGTGTTATTGTCACCGGCGTGCGCAAGTCTCGATCAATTTAAGAACTTTGAAGAACGCGGACAGGTTTT
TGTTAAATTAGCTCAGGAAGTAACCGCTTAA

Protein sequence :
MQNQYKDKVITVIGLGKTGLSCVEFLADKQAKVQVIDTREKPAGADQLPADVPLHTGGLNSEWLLASDLIVISPGLALAT
PEIQQAINAGMEVVGDIELFVREAKAPIIAITGANGKSTVTTLVTEMAKQAGIKVGMGGNIGVPVLSLLNDEYELFVLEL
SSFQLETTSSLNAVAATILNISEDHMDRYNNSLEEYRLAKLRIYDNAENVIVNGEDRLTYPLETQAVKKLIRFAEHNAEY
TMRNGILYSGDDAIIPTKEMLISGRHNEMNSLAAMALAEAAGIPREGIVKALQVYGGLNHRFQAVKTNDGVRWVNDSKAT
NVGSTVAALNGLQVAGTLYLLLGGDGKAADFSELKPLINKPNIVCYCFGQDGAQLAALSSQSVLVETMQQAIEQIRPQLK
KGDMVLLSPACASLDQFKNFEERGQVFVKLAQEVTA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 1e-67 46
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 1e-67 46