Gene Information

Name : tpx (APL_1489)
Accession : YP_001054178.1
Strain : Actinobacillus pleuropneumoniae L20
Genome accession: NC_009053
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 1704458 - 1704958 bp
Length : 501 bp
Strand : +
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGAGTAATGTAACTTTAATGGGTAATCCGATTACCGTTGCCGGTATTTTTCCACAAGTGGGCGATACGGTTGCCGATTT
TAGCCTAGTGAATAACGGTTTGGAAAATGTGGCGTTAGCAAGTTTTGCAGGAAAACGTAAAGTATTAAATATTTTCCCAA
GTATCGATACCGGCGTATGTGCGACTTCAGTACGTGTGTTTAACCAAAAAGCGGCTGATTTAAGCAATACGGTTGTGCTT
TGTATTTCCGCCGATTTACCTTTTGCACAGGCGCGTTTCTGTGGTGCGGAAGGGATCGAAAACGTACAAACCCTTTCAAC
ATTCCGTAATAAAGCGGCACATAACGCATTAGGTGTGGATATTCAAAGCGGCCCGCTTGCCGGTTTAACTTCACGTTCCG
TTATCGTATTAGACGAAAATAATCGCGTGTTACACAGCGAATTGGTTTCCGAAATTAAAAACGAACCGAATTACGAAGCG
GCATTAGCGGTTTTAGCTTAA

Protein sequence : 
MSNVTLMGNPITVAGIFPQVGDTVADFSLVNNGLENVALASFAGKRKVLNIFPSIDTGVCATSVRVFNQKAADLSNTVVL
CISADLPFAQARFCGAEGIENVQTLSTFRNKAAHNALGVDIQSGPLAGLTSRSVIVLDENNRVLHSELVSEIKNEPNYEA
ALAVLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 1e-34 47
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 2e-34 47
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 1e-34 46
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 2e-34 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001054178.1 thiol peroxidase VFG0087 Protein 5e-35 46