Gene Information

Name : Cthe_0312 (Cthe_0312)
Accession : YP_001036743.1
Strain : Clostridium thermocellum ATCC 27405
Genome accession: NC_009012
Putative virulence/resistance : Virulence
Product : ATPase AAA-2
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG0542
EC number : -
Position : 392714 - 395125 bp
Length : 2412 bp
Strand : +
Note : PFAM: AAA ATPase, central region; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2; SMART: ATPase; KEGG: cac:CAC0904 ATPase with chaperon activity, two ATP-binding domains, ClpC orthologs

DNA sequence :
ATGATGATGTGCTCAATTTGCAAAGAAAATTTGGCTGTTGTTTTTATTACCAAGATAATAAACGGCAAGCAAACCCAGGA
AGGTTTGTGTTTTTCCTGTGCAAAGAAACAGGGAATTCAGCCTATAAATCAAATATTGGAACAAACCGGCATATCCGAAG
AAGAAATAGATGGTTTGAACAAGCAGATGGAAACGTTTTTTGAAGACATGGATTTTTCCGGTACGAGTGACCCTGAGGGG
GGCACAGCCACTGCCAATCCGTTTTTTAATCTGATTAACAAATCCCTGAACAAGACGATGGAAAGTATGGGATTTAAAAG
TTCAAAGGATGAAACGGAGTCCGACGGCAAGACGGACAGGGAAGTTAAGGACGATAAAAACAATACAAGGACGAAGACCC
AGGACAAAAAGATGCCGAAGAAGAAAAAGTATCTTGATACTTACGGCACAAATCTGATTGTCAAGGCTAAAGAGGGAAAA
ATAGACCGTGTTATTGGGAGAAACAGGGAAATTGAAAGAGTAATTCAGATATTGAACAGAAGAAATAAAAACAATCCGGT
TTTAATCGGTGAACCGGGTGTGGGTAAGACTGCAATTGCGGAAGGTCTTGCTTTGAGAATCGTTAACAGGGATGTTCCGG
TAAAGCTCTTTAACGCCGAGGTTTATGTGCTTGACCTTACAAGCATAGTAGCGGGAACCCAGTTCAGAGGCCAGTTTGAA
AACCGAATGAAGGGTATTATAGAGGAATGCAAGGCTCTGGGAAATATAATACTGGTTATAGATGAAATTCATAATATTAT
GGGCGCAGGAGAGGCCGAAGGAGCCATGAATGCCGCCAACATTTTAAAACCTGCTCTGGCAAAAGGTGAGATACAGGTTA
TTGGTGCCACCACCCTTGATGAGTACAGAAAGCACATTGAAAAGGACTCCGCGTTGGAAAGAAGATTCCAGCCGGTGCTG
GTGGATGAGCCTTCTGTTGAGGAAACCATAGAGATATTGCGGGGTATAAAGGACTATTATGAAAGTTATCACAGGGTTAA
AATATCCGATGAGGTAATACGGGCGGCGGTGATTCTTTCCGAAAGATATATCACGGACAGATTCCTTCCGGACAAGGCGA
TAGATGTGCTGGATGAGGCAGGTTCAAGAGCCAATATTAAAAATGTTGTCCTTTTGGAGTATGAAGCTTTGAAGGAGGAG
CTTAAGAAGGTACAGGAAGAAAAGGAAAATGCGGTTTCGGCGGATTCCATTGAGGACTATCAGAAGGCGGCCGACCTTAA
GGTAAGGGAATGCAAGCTTCTTCAGCAGATAAAAGAACTTGAGCAGAAGAGCAAGGACATGGAACTGACCGTCGATGATA
TAGCATATGTTATAGAGTCATGGACCAAGATTCCGGTTCAGAGGCTTACAGAAATTGAAGCCGAAAAACTTCTCAATCTT
GAAGAAAGGCTTCATAAAAGAGTCATTGGGCAGCACGAAGCTGTAAAGAGCGTTGCAAGGGCAATTAGAAGGAACAGGGC
TGACTTTAAAAAGAGGAAAAAACCGGCGTCATTTATTTTCGTCGGTCCTACCGGTGTGGGTAAAACGGAGCTGGTAAAGG
CGCTGGCGGTGGAGTTGTTTGGAAGTGAGGAAGCGCTTATCAGGCTTGATATGTCCGAATACATGGAAAAGCATACTGTA
TCCAAGCTTATTGGCGCACCTCCGGGTTATGTGGGCTATGATGAAGGCGGCCAGCTTACTGAAAAAGTAAGGAGAAAGCC
TTATTCGGTAATACTTTTGGATGAAATTGAAAAGGCACACCCGGATGTGTTTAATATGCTGCTTCAAATTTTGGATGACG
GAAGGGCAACGGACAGTCACGGCAGAACTGTAAGTTTTGAAAATACGGTGCTGATAATGACATCCAATGCAGGGACCAGC
CTTAAGGCAAGCAGCATAGGTTTTGCAAACGACAACTATATTGCTCTTGAGAATAAAGTCAAGGAGGTTTTGAAGGAAAC
TTTCAGGCCGGAGTTCTTGAACAGGGTGGATGAAATTATAGTATTTAATCATCTTACCAAAGATGAACTTAAGCAGATAG
TTGATTTGATGTTCAAAGATGTTGTTGAGGAAGTGGAAAACAAGAAGATGACCGTCAAATTCCAAGACGGAGTTCGGGAG
TTCATTCTTGAAAAGGGCTATGATCCCAAGTACGGTGCAAGGCCTCTTAGAAGGACAATACAGAGGTATATTGAAGACGA
GCTTGCAGAAATGTATCTTAAAGGTTTGCTTGCTGAAGGCTGCAGCATTGTGGTTGGTGTCAGGGACGGGAACATTGTGT
TTAATGTGGAAAAACCGGCGGAAAACGCGGTAGTGGATACGGAGAATTCAACGACCGATAATATGAAAACAGATAACACA
ACCGCTGAATGA

Protein sequence :
MMMCSICKENLAVVFITKIINGKQTQEGLCFSCAKKQGIQPINQILEQTGISEEEIDGLNKQMETFFEDMDFSGTSDPEG
GTATANPFFNLINKSLNKTMESMGFKSSKDETESDGKTDREVKDDKNNTRTKTQDKKMPKKKKYLDTYGTNLIVKAKEGK
IDRVIGRNREIERVIQILNRRNKNNPVLIGEPGVGKTAIAEGLALRIVNRDVPVKLFNAEVYVLDLTSIVAGTQFRGQFE
NRMKGIIEECKALGNIILVIDEIHNIMGAGEAEGAMNAANILKPALAKGEIQVIGATTLDEYRKHIEKDSALERRFQPVL
VDEPSVEETIEILRGIKDYYESYHRVKISDEVIRAAVILSERYITDRFLPDKAIDVLDEAGSRANIKNVVLLEYEALKEE
LKKVQEEKENAVSADSIEDYQKAADLKVRECKLLQQIKELEQKSKDMELTVDDIAYVIESWTKIPVQRLTEIEAEKLLNL
EERLHKRVIGQHEAVKSVARAIRRNRADFKKRKKPASFIFVGPTGVGKTELVKALAVELFGSEEALIRLDMSEYMEKHTV
SKLIGAPPGYVGYDEGGQLTEKVRRKPYSVILLDEIEKAHPDVFNMLLQILDDGRATDSHGRTVSFENTVLIMTSNAGTS
LKASSIGFANDNYIALENKVKEVLKETFRPEFLNRVDEIIVFNHLTKDELKQIVDLMFKDVVEEVENKKMTVKFQDGVRE
FILEKGYDPKYGARPLRRTIQRYIEDELAEMYLKGLLAEGCSIVVGVRDGNIVFNVEKPAENAVVDTENSTTDNMKTDNT
TAE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
clpC YP_005163377.1 ATP-dependent Clp protease ATP-binding subunit Not tested Not named Protein 8e-159 54

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Cthe_0312 YP_001036743.1 ATPase AAA-2 VFG0079 Protein 8e-163 56
Cthe_0312 YP_001036743.1 ATPase AAA-2 VFG0080 Protein 4e-147 50