Gene Information

Name : Cthe_2381 (Cthe_2381)
Accession : YP_001038776.1
Strain : Clostridium thermocellum ATCC 27405
Genome accession: NC_009012
Putative virulence/resistance : Unknown
Product : seryl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0172
EC number : 6.1.1.11
Position : 2845403 - 2846674 bp
Length : 1272 bp
Strand : +
Note : catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA

DNA sequence :
ATGCTTGACATTAAATTGATTAGAAGTAATCCCGAAATATTAAAAAAAGCTCTTCAAAAAAGAAAAGACAATTTTGATGT
GAACGGGCTTTTAAGCCTTGATGAGAAAAGAAGAAAAACTCTCGTGGAACTGGAACAACTAAGAAACAAACAGAATGAGA
ATTCAAAGCTTATTCCCAAATACAAAAAAGAAGGAAAAGATGTATCATCTCTGATGGAGGAAATGAAAAGTCTTTCGGAA
AAAATAAAAGCTCTCGATGCGGAAGTCAGAAAGATTGACGAGGAATTGAACGCAATTCTTCTGACCATACCCAATATACC
ACATGAAAGTGTTCCGATGGGAGACAGTGACGAGGACAACGTTGAGGTAAGAAGATGGGGTGAACCCAGAAAATTTGATT
TTACTCCAAAGCCGCACTGGGAGATAGGAGAAAATCTCGACATACTCGACTTTTCCAAAGCTGCAAAAGTGACAGGGGCA
AGATTTACATTTTACAAGGGACTTGGGGCAAGACTTGAAAGAGCTCTAATGAACTTCATGCTGGATCTGCATGTCGATAA
ACATGGGTATGTGGAAGTATTTCCACCGTTTTTGGTACATAGAAACAGTATGATTGGAACGGGCCAACTGCCCAAATTTG
AAGAAGATGCATTTAAAGTAAGTGATACCGATTATTTCCTGATACCGACTGCCGAAGTGCCAGTAACCAACATGTACAGG
GAACAAATACTTGACGTGAAAGACCTTCCCATAAAGCATGTTGCATATTCGGCATGCTTCAGAGCGGAGGCCGGTGCTGC
AGGAAGGGATACAAGAGGTCTTATAAGACAGCATCAATTTAACAAAGTTGAGCTTGTAAAATTCACAACACCTGAGACAT
CCTATGAAGAACTGGAAAAGCTCACAAGAGATGCTGAGGAAGTATTGCAGATGTTGGAAATTCCATACAGAGTGGTGAAG
ATATGTGTGGGAGACCTTGGATTCACGGCGGCAATGAAATATGACATAGAAGTATGGATGCCCAGCTACAACAGATATGT
GGAAATATCCTCATGCAGTAACTTTGAGGACTTCCAGGCAAGAAGAGCAGGAATAAAGTTCAGGAGAGGACTAAATGAAA
AACCGGAGTTTGTTCATACTTTGAATGGCTCAGGAGTTGCAATGGGAAGAGCAACCGCCTGCATACTTGAAAACTATCAG
CAGGAAGACGGATCGGTCGTTGTGCCCAAGGTCCTCAGGGAGTATTTAGGAGGCATCAGTGTAATTAAATAG

Protein sequence :
MLDIKLIRSNPEILKKALQKRKDNFDVNGLLSLDEKRRKTLVELEQLRNKQNENSKLIPKYKKEGKDVSSLMEEMKSLSE
KIKALDAEVRKIDEELNAILLTIPNIPHESVPMGDSDEDNVEVRRWGEPRKFDFTPKPHWEIGENLDILDFSKAAKVTGA
RFTFYKGLGARLERALMNFMLDLHVDKHGYVEVFPPFLVHRNSMIGTGQLPKFEEDAFKVSDTDYFLIPTAEVPVTNMYR
EQILDVKDLPIKHVAYSACFRAEAGAAGRDTRGLIRQHQFNKVELVKFTTPETSYEELEKLTRDAEEVLQMLEIPYRVVK
ICVGDLGFTAAMKYDIEVWMPSYNRYVEISSCSNFEDFQARRAGIKFRRGLNEKPEFVHTLNGSGVAMGRATACILENYQ
QEDGSVVVPKVLREYLGGISVIK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
serS YP_003446791.1 seryl-tRNA synthetase Not tested The aminoglycoside resistance gene cluster Protein 1e-115 58