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Name : ureC (Cthe_1816) Accession : YP_001038230.1 Strain : Clostridium thermocellum ATCC 27405 Genome accession: NC_009012 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : 3.5.1.5 Position : 2150837 - 2152555 bp Length : 1719 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGTGTAAAAATAAGCGGCAAAGATTATGCCGGTATGTATGGCCCGACAAAAGGCGACAGGGTGAGGCTGGCAGACAC GGATCTCATTATTGAGATTGAGGAAGATTACACGGTTTATGGAGATGAGTGCAAATTCGGAGGAGGTAAATCCATAAGGG ACGGAATGGGCCAGTCTCCTTCGGCTGCAAGAGATGACAAGGTTTTGGATTTGGTAATTACCAATGCCATAATCTTTGAC ACATGGGGGATTGTAAAGGGAGATATAGGTATAAAAGACGGAAAAATAGCCGGAATCGGGAAGGCGGGAAATCCGAAAGT AATGAGCGGCGTGTCGGAGGATTTAATAATCGGGGCCTCTACCGAAGTTATTACCGGAGAAGGACTTATTGTGACTCCGG GAGGAATTGATACACATATACATTTTATATGCCCCCAGCAGATTGAGACCGCATTGTTCAGCGGTATCACAACAATGATT GGTGGCGGAACGGGACCGGCAGACGGAACCAATGCCACCACTTGCACACCGGGAGCCTTTAACATCCGGAAAATGTTAGA GGCGGCAGAGGACTTTCCGGTAAATTTAGGTTTTTTGGGGAAAGGGAATGCTTCTTTTGAGACTCCTCTGATAGAACAGA TTGAAGCAGGGGCGATTGGCTTAAAGCTCCATGAGGATTGGGGAACCACACCCAAGGCTATAGATACATGCCTGAAAGTT GCGGATCTTTTTGATGTACAGGTGGCTATACATACCGATACACTGAACGAGGCAGGATTTGTAGAGAATACTATAGCGGC TATAGCCGGAAGGACAATTCACACTTACCATACCGAGGGAGCGGGCGGCGGGCACGCACCGGACATAATTAAAATTGCAT CACGCATGAATGTACTGCCCTCGTCTACCAATCCCACCATGCCTTTTACCGTCAATACATTGGATGAACATCTCGATATG CTTATGGTATGCCATCATCTTGACAGCAAGGTAAAAGAGGACGTTGCTTTTGCCGATTCGAGGATCCGGCCTGAGACAAT AGCCGCAGAAGACATACTGCACGATATGGGAGTATTCAGCATGATGAGTTCCGATTCCCAGGCCATGGGACGCGTGGGAG AGGTTATTATAAGGACCTGGCAGACTGCACATAAAATGAAGCTTCAAAGAGGTGCCCTGCCGGGGGAAAAGAGCGGCTGT GACAATATAAGGGCTAAAAGATACCTTGCCAAGTATACCATAAACCCTGCTATAACCCATGGAATTTCACAGTATGTGGG CTCCCTGGAGAAAGGGAAAATAGCCGACTTGGTCCTCTGGAAGCCTGCAATGTTTGGTGTAAAGCCTGAAATGATTATTA AGGGCGGCTTTATAATAGCCGGCAGGATGGGCGATGCAAATGCGTCCATACCCACACCTCAGCCTGTAATATATAAAAAC ATGTTCGGTGCCTTCGGAAAGGCAAAGTACGGAACCTGTGTGACTTTTGTTTCAAAGGCTTCGCTGGAAAATGGCGTTGT GGAAAAGATGGGGCTTCAAAGAAAAGTGCTTCCGGTCCAGGGATGCAGGAATATCTCAAAAAAATATATGGTACACAACA ATGCAACGCCTGAAATTGAAGTTGATCCTGAAACCTATGAGGTAAAGGTGGACGGTGAGATTATCACCTGCGAACCATTA AAGGTCTTACCCATGGCGCAGAGATATTTCTTGTTTTAA Protein sequence : MSVKISGKDYAGMYGPTKGDRVRLADTDLIIEIEEDYTVYGDECKFGGGKSIRDGMGQSPSAARDDKVLDLVITNAIIFD TWGIVKGDIGIKDGKIAGIGKAGNPKVMSGVSEDLIIGASTEVITGEGLIVTPGGIDTHIHFICPQQIETALFSGITTMI GGGTGPADGTNATTCTPGAFNIRKMLEAAEDFPVNLGFLGKGNASFETPLIEQIEAGAIGLKLHEDWGTTPKAIDTCLKV ADLFDVQVAIHTDTLNEAGFVENTIAAIAGRTIHTYHTEGAGGGHAPDIIKIASRMNVLPSSTNPTMPFTVNTLDEHLDM LMVCHHLDSKVKEDVAFADSRIRPETIAAEDILHDMGVFSMMSSDSQAMGRVGEVIIRTWQTAHKMKLQRGALPGEKSGC DNIRAKRYLAKYTINPAITHGISQYVGSLEKGKIADLVLWKPAMFGVKPEMIIKGGFIIAGRMGDANASIPTPQPVIYKN MFGAFGKAKYGTCVTFVSKASLENGVVEKMGLQRKVLPVQGCRNISKKYMVHNNATPEIEVDPETYEVKVDGEIITCEPL KVLPMAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 5e-163 | 65 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 5e-163 | 65 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-155 | 64 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 4e-155 | 64 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 4e-155 | 64 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 7e-155 | 64 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_001038230.1 | urease subunit alpha | VFG0270 | Protein | 2e-170 | 69 |
