Gene Information

Name : Cthe_1559 (Cthe_1559)
Accession : YP_001037978.1
Strain : Clostridium thermocellum ATCC 27405
Genome accession: NC_009012
Putative virulence/resistance : Resistance
Product : cystathionine gamma-lyase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 4.4.1.1
Position : 1887838 - 1889001 bp
Length : 1164 bp
Strand : +
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: hhe:HH0062 cystathionine gamma-synthase

DNA sequence :
TTGGCACATTACAAACATATTGAATCGGCAGTCATCCATGGTGGCATTTATGGAGATTTCCATACCGGTTCGGTAAATAC
CCCTATTTATCAAACCTCCACCTTTGAACAGGACGGTTTGGGCAAGCCCCGCTCAAATTGGGAATATTCCCGAACGGGAA
ATCCCACTCGGGCAGCTTTGGAGGCTTTGATTGCAGAGTTGGAGGGTGGGTCCCGGGGATTTGCATTTTCTTCCGGTATG
GCAGCCATTGATGCAGTTCTGCATCTCTTCCAATCCGGAGACAGCGTCATTATTTCCGACAATGTATATGGAGGGACTTT
TCGAATTCTGGATAAAATCTTCAAGCAGTATGGCTTAAACTATAAAATTGTGGACACCACTGATTTGGCAGCACTCGAAA
GTGCATTTACTTCGGATGTTAAAGCTTTGTTGCTTGAATCCCCGGCCAATCCGCTGCTCAAAGTTACGGATATCGCGGCG
GCAGCTGAGATAGCAAGATCCAAAGGAGCGCTGACTGTAGTGGATAACACCTTTATGACCCCTTATCTTCAACGGCCTTT
AGAGCTTGGAGCGGATATCGTCGTGCATTCGGCAACCAAATATCTTGGCGGACATAGCGATGTCATTGCAGGACTTGTCA
TCGTTAAAGACGGTGAACTGGCAGAAAAGCTGCATTTCATACAAAATGCGGTGGGTGCCGTTGCCGGGCCGTTTGATTCT
TTCCTGCTCATTCGAAGTATCAAGACGTTGGCAGTGCGCATGGAAGCCCATGTGGCCAACGCAGAAAAACTAGCAGAGGC
TTTAAAAAGTAATCCGGCAGTTAAAAACGTCTATTATCCCGGCTTAAAATCCGCTCAAGGATATGAGATTCAAAAGAGAC
AGGCAAAAAACGGCGGAGCCATGATTTCCTTTGAGTTACATAACAATTATGACATCAACAGGTTTTTTGAAGGTTTGGAG
TTGATTGCCCTTGCGGAAAGCTTGGGCGGTGTTGAAAGTCTTGTCTGCCATCCTTCAAGCATGACCCATGCATCTGTTCC
AAAGGAAATACGCGAAAAGATCGGCATCACGGATACATTGATCCGCTTGTCGGTAGGTATTGAAAATTATGATGATTTAA
AAAACGATTTATTTTCTGCTATAAAAGGAGCGCGAGTACTATGA

Protein sequence :
MAHYKHIESAVIHGGIYGDFHTGSVNTPIYQTSTFEQDGLGKPRSNWEYSRTGNPTRAALEALIAELEGGSRGFAFSSGM
AAIDAVLHLFQSGDSVIISDNVYGGTFRILDKIFKQYGLNYKIVDTTDLAALESAFTSDVKALLLESPANPLLKVTDIAA
AAEIARSKGALTVVDNTFMTPYLQRPLELGADIVVHSATKYLGGHSDVIAGLVIVKDGELAEKLHFIQNAVGAVAGPFDS
FLLIRSIKTLAVRMEAHVANAEKLAEALKSNPAVKNVYYPGLKSAQGYEIQKRQAKNGGAMISFELHNNYDINRFFEGLE
LIALAESLGGVESLVCHPSSMTHASVPKEIREKIGITDTLIRLSVGIENYDDLKNDLFSAIKGARVL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 5e-84 51
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 3e-85 51
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 3e-64 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Cthe_1559 YP_001037978.1 cystathionine gamma-lyase BAC0207 Protein 2e-65 46