Gene Information

Name : pykF (SSA_0848)
Accession : YP_001034825.1
Strain : Streptococcus sanguinis SK36
Genome accession: NC_009009
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 834579 - 836084 bp
Length : 1506 bp
Strand : +
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
ATGAATAAACGTGTAAAAATCGTTGCAACATTAGGTCCTGCGGTAGAAATCCGCGGTGGTAAAAAATTCGGTGATGACGG
ATATTGGGGAGAAAAGCTGGATGTTGAAGCATCAGCTCAAAACATAGCTAAGCTGATTGAAGCTGGCGCAAATACATTCC
GTTTCAACTTCTCACACGGTGACCATGCTGAGCAAGGAGAGCGCATGGCAACTGTTAAGCGTGCAGAAGAAATTGCCGGC
CAAAAAGTTGGTTTCCTACTTGATACAAAAGGACCAGAAATTCGTACAGAATTGTTTGAAGGCGATGCAAAAGAGTACTC
TTACAAAACTGGTGAAAAAATCCGTGTTGCTACTAAGCAAGGTATCAAATCAACTCGTGATGTGATTGCTTTGAACGTTG
CTGGTGCCCTTGACATCTACGATGATGTTGAAGTTGGTCACCAAGTTTTGGTTGACGATGGTAAACTTGGTCTTCGTGTT
TTCTCAAAAGACGATGCAACTCGTGAATTTGAAGTAGTCGTTGAAAATGACGGTATCATTGCTAAGCAGAAAGGTGTGAA
CATCCCTAACACTAAGATTCCTTTCCCAGCACTTGCTGAGCGCGATAATGATGATATCCGTTTCGGTTTGGAACAAGGTA
TCAACTTCATCGCGATTTCATTCGTACGTACTGCAAAAGACGTCGACGAAGTTCGTGCAATCTGTGAAGAAACTGGCAAC
GGCCATGTTCAATTGTTCGCGAAAATCGAAAACCAACAAGGTATCGATAACTTGGACGAAATCATTGAAGCTGCTGACGG
TATCATGATTGCCCGTGGTGACATGGGTATCGAAGTACCATTCGAAATGGTTCCAGTTTACCAAAAGATGATCATAACTA
AGGTAAATGCAGCTGGTAAAGTGGTTATCACAGCAACTAACATGCTTGAAACCATGACAGAAAAACCACGTGCAACTCGT
TCAGAAGTATCAGACGTATTTAACGCTGTTATCGATGGAACTGACGCAACTATGCTTTCAGGTGAGTCTGCAAATGGTAA
ATACCCACTTGAGTCAGTAACAACAATGGCGACTATCGATAAGAATGCTCAAACCCTTCTTAACGAATATGGCCGCTTGA
CAACTGATAACTTTGAGCGTAACTCTAAGACTGAAGTTATGGCTTCAGCGGTTAAAGATGCTACAAACTCAATGGATATC
AAGTTGGTAGTTACCCTTACTAAGACTGGTCACACAGCTCGCTTGATTTCTAAATACCGTCCAAATGCTGATATCTTAGC
TATCACTTTTGACGAATTGACTCAACGTGGTCTTATGCTGAACTGGGGTGTTATTCCAGTGACTACTGAAACTCCATCTA
ACACAGATGATATGTTTGAAATCGCTGAAAAGATTGCAGTTGAGCAAGGCTTGGTTGAATCTGGTGATGATATCGTTATC
GTTGCTGGTGTGCCGCTTGGTGAAGCAGTTCGTACCAACACAATGCGTATCCGTACAGTACGTTAA

Protein sequence :
MNKRVKIVATLGPAVEIRGGKKFGDDGYWGEKLDVEASAQNIAKLIEAGANTFRFNFSHGDHAEQGERMATVKRAEEIAG
QKVGFLLDTKGPEIRTELFEGDAKEYSYKTGEKIRVATKQGIKSTRDVIALNVAGALDIYDDVEVGHQVLVDDGKLGLRV
FSKDDATREFEVVVENDGIIAKQKGVNIPNTKIPFPALAERDNDDIRFGLEQGINFIAISFVRTAKDVDEVRAICEETGN
GHVQLFAKIENQQGIDNLDEIIEAADGIMIARGDMGIEVPFEMVPVYQKMIITKVNAAGKVVITATNMLETMTEKPRATR
SEVSDVFNAVIDGTDATMLSGESANGKYPLESVTTMATIDKNAQTLLNEYGRLTTDNFERNSKTEVMASAVKDATNSMDI
KLVVTLTKTGHTARLISKYRPNADILAITFDELTQRGLMLNWGVIPVTTETPSNTDDMFEIAEKIAVEQGLVESGDDIVI
VAGVPLGEAVRTNTMRIRTVR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 2e-79 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 8e-80 42
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 8e-80 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 3e-80 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
pykF YP_001034825.1 pyruvate kinase VFG0479 Protein 3e-80 42