Gene Information

Name : tpx (SSA_0259)
Accession : YP_001034268.1
Strain : Streptococcus sanguinis SK36
Genome accession: NC_009009
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 1.11.1.-
Position : 253103 - 253633 bp
Length : 531 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence :
ATGTACAATGAAGCTATCAAACATGAATGGAGACTTCCTATGACAACTTTTCTCGGAAATCCTGTAACCTTTACTGGAAA
GCAACTGCAAGTCGGCGACACCGCCCACGATTTTAGCCTGACAGCAACTGACCTTTCAAAGAAAACTCTGGCTGACTTTG
CTGGCAAAAAGAAAGTCCTGAGCATCATCCCATCTATCGATACTGGTGTCTGTTCGACTCAGACTCGTCGTTTCAATCAA
GAACTCTCTGACTTGGACAATACCGTTGTTATCACGGTTTCAGTTGATTTGCCTTTTGCTCAAGGCAAGTGGTGTGCTGC
TGAAGGCATTGAGAATGCTGTCATGCTCTCTGACTACTTCGACCATTCTTTCGGCCGTGACTATGCTGTCCTCATCAATG
AATGGCACCTTTTGGCCCGTGCGGTTCTTGTCTTAGACGAAAACAACACTGTGACCTACGCTGAATATGTCGACAATATC
AATACCGAGCCTGACTATGATGCGGCGATTGCAGCAGTTAAGAGTTTATAA

Protein sequence :
MYNEAIKHEWRLPMTTFLGNPVTFTGKQLQVGDTAHDFSLTATDLSKKTLADFAGKKKVLSIIPSIDTGVCSTQTRRFNQ
ELSDLDNTVVITVSVDLPFAQGKWCAAEGIENAVMLSDYFDHSFGRDYAVLINEWHLLARAVLVLDENNTVTYAEYVDNI
NTEPDYDAAIAAVKSL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 5e-22 42
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 2e-22 42
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 3e-22 42
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 2e-22 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001034268.1 thiol peroxidase VFG0087 Protein 6e-23 42