Gene Information

Name : guaA (llmg_1008)
Accession : YP_001032328.1
Strain : Lactococcus lactis MG1363
Genome accession: NC_009004
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 972641 - 974182 bp
Length : 1542 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGTCCGACACTACACTTGAAAAAATCATTGTACTCGACTATGGTTCACAATACAATCAACTTATTGCGCGTCGTATCCG
AGAAATCGGTGTTTTCTCAGAACTCATGAGTCACAAAGTCACAGCCAAAGAAATTCGTGAGATTAATCCAATCGGTATTA
TTCTTTCAGGCGGTCCAAATTCAGTTTATGATGAAGGTTCATTCGATATTGACCCTGAAATCTTCGAACTTGGTTTGCCA
GTTCTTGGTATTTGCTACGGCATGCAATTGATGAGCTACAAACTTGGCGGTATGGTAGAAGCAGCAGGCGAACGCGAATA
CGGCGTTGCACCACTTCAACTCACTGAAAAATCAGCATTGTTTGCAGGAACTCCAGAAGTTCAAGATGTTTTGATGAGCC
ATGGTGACCGTGTAACAGCTATTCCTGAAGGTTTCCACGTTGTCGGAACTTCACCAAACAGTCCATTTGCTGCCGTTGAA
AACACTGAACGCAATTTGTACGGCATCCAATTTCACCCAGAAGTTCGTCATTCAGTTCACGGAACAGAAATGCTCAGAAA
CTTTGCGCTTAACATCTGTGGAGCCAAAGGGAACTGGTCAATGGAAAACTTCATTGATATGCAAATCAAAGATATTCGTG
AAAAAGTTGGCGACAAAAAAGTACTCCTTGGACTTTCAGGCGGTGTAGATTCATCAGTTGTGGGTGTTCTTTTACAACGT
GCCATTGGTGACCAATTGACATCAATCTTTGTTGACCACGGTTTCCTTCGTAAAGGCGAAGCTGACCAAGTCATGGAAAC
ATTGGGCGGAAAATTTGGTCTTAATATCATCAAAGTAGATGCTCAAAAACGTTTCATGGACAAACTTGTTGGCCTTTCAG
ACCCAGAAACAAAACGTAAAATTATCGGTAACGAATTTGTTTATGTTTTTGATGATGAAGCAAACAAATTAGAAGGTGTT
GACTTCCTTGCTCAAGGAACACTTTACACCGATGTCATTGAATCAGGAACAGATACAGCTCAAACAATTAAGTCACACCA
TAATGTTGGTGGACTTCCAGAAGACATGCAATTCCAATTGATTGAACCATTGAACACACTTTTCAAAGATGAAGTTCGTG
CGCTTGGAACACAACTTGGAATGCCTGATGAAATTGTTTGGCGTCAACCTTTCCCAGGTCCAGGACTTGCCATTCGTGTC
CTTGGTGATTTAACAGAAGAAAAATTAGAAACTGTTCGCGAATCAGACGCAATTCTTCGCGAAGAAATTGCTGCTTCAGG
ACTTGAACGTGATGTTTGGCAATATTTCACAGTAAATACAGACGTGAAATCAGTCGGTGTCATGGGAGACCAACGGACAT
ATGACTATACATTAGCCATCCGTGCCATCACTTCAATTGATGGGATGACAGCAGACTTTGCCCAACTTCCTTGGGATCTT
CTCCAAAAAATCTCAAAACGTATCGTCAATGAGGTTGACCACGTCAACCGTATCGTCTACGATATTACGAGCAAACCACC
AGCAACTGTTGAGTGGCAATAG

Protein sequence :
MSDTTLEKIIVLDYGSQYNQLIARRIREIGVFSELMSHKVTAKEIREINPIGIILSGGPNSVYDEGSFDIDPEIFELGLP
VLGICYGMQLMSYKLGGMVEAAGEREYGVAPLQLTEKSALFAGTPEVQDVLMSHGDRVTAIPEGFHVVGTSPNSPFAAVE
NTERNLYGIQFHPEVRHSVHGTEMLRNFALNICGAKGNWSMENFIDMQIKDIREKVGDKKVLLGLSGGVDSSVVGVLLQR
AIGDQLTSIFVDHGFLRKGEADQVMETLGGKFGLNIIKVDAQKRFMDKLVGLSDPETKRKIIGNEFVYVFDDEANKLEGV
DFLAQGTLYTDVIESGTDTAQTIKSHHNVGGLPEDMQFQLIEPLNTLFKDEVRALGTQLGMPDEIVWRQPFPGPGLAIRV
LGDLTEEKLETVRESDAILREEIAASGLERDVWQYFTVNTDVKSVGVMGDQRTYDYTLAIRAITSIDGMTADFAQLPWDL
LQKISKRIVNEVDHVNRIVYDITSKPPATVEWQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 5e-171 70
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-171 70
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 8e-171 69
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-122 50