Gene Information

Name : guaA (Mlab_1133)
Accession : YP_001030569.1
Strain : Methanocorpusculum labreanum Z
Genome accession: NC_008942
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1145912 - 1147438 bp
Length : 1527 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGAATCGATATTAGTCCTTGATTTCGGCGGCCAGTACAACCAGCTGATCTCCCGCCGCGTCAGAGAAGCACATGTTTT
CTGCGAAGTAAAGCCCTGCACGATCCCCCTTTCGGAAATAAAAGAAGGAAACTATGCGGGAATTATTTTCACCGGCGGAC
CGGCGAGCGTGTATGCGAAGAACGCTCCGACCGTTGATGCCGGTATCTTCGAGCTAGGAATCCCGATTCTCGGGATCTGC
TACGGCGCACAGCTCACGGCATATCTCCTTGGAGGAAACGTCGCTTCTGCGACGACCCGCGAGTACGGCAAAACTTCCAT
TTCAACGGAAGAGTCCCCTATCTTCAAAAATGTCCCAAGAGAGACGACCTGCTGGATGAGCCACACGGATTACATCAGCG
AGGTCCCTGCCGGATTCGTCAAGGTCGCCCACACGAGTGTGTGCCCGGTCGCCGCCATGGCAAACCCCGCAAAGAAGATC
TACGCGGTCCAGTTCCACCCCGAGGTCATGCACACCCCTGAGGGCATGACGATGATCAAAAACTTCCTTTACGATGTCTG
CGGGTGCAAAGGAACCTGGCATATGTCCTCTTTTGTCGAGGATCAGGTCCTGCAGCTTCGCGAGAAGATCGGCGACAAAA
AAGTCCTCTGTGCCCTCTCCGGCGGCGTCGACTCATCCGTTGCCGCTGTTTTGATCAACAAAGCGGTCGGCAAACAACTG
ACCTGCATCTTTGTCGATCACGGTCTTCTCAGAAAGAACGAGGGTAACGAGGTCGAAGAGATCTTCAGAAATCAGTTCGA
TATCAATCTGATCCGCGTCAATGTCGAGGACCAGTTCCTCGGAAAACTCGCCGGCGTTTCCGACCCTGAAAAGAAACGCA
AGATCATCGGCGAGGAGTTCATCCGCGTCTTCGAAGCAGAGGCAAAAAAGATCGGCACGGTCGATTTCCTTGTGCAGGGA
ACGATCTATCCCGATGTGATAGAGTCAGGACCGGGCGCGGCTGCCGTGATCAAAAGCCACCACAATGTCGGCGGTCTGCC
GGACAATGTGGATTTCAAGGAGATCATCGAGCCGCTTCGTATCCTTTTCAAGGATGAGGTCCGCCGGGCCGGTCTCGAAC
TCGGCATCCCTGAGAAGCTTGTCTGGCGTCAGCCGTTCCCGGGCCCGGGTCTTGCTATCCGGGTGATCGGCGACATCACA
AAAGAAAAACTCGAGATCGTCCGCGACGCCGATGCGATCTACCGCGAGGAGATCGCCAAAGCCGGAATCGATCGGGACAT
CAATCAGTATTTTGCGGCCTTAACGAATATGCGCAGCGTCGGTGTGATGGGCGATGAGAGGACATATGACTACGCCGTCG
TTTTGCGGGCCGTAACAACGACCGATTTCATGACTGCCGACTGGGCCCAGATCCCGTTTGCGGTGCTTGAAAAGGTTTCA
AGCCGGATCATCAACGAAGTCAGGCACGTGAACCGGGTCTTATACGACATTACAAGCAAGCCTCCGGCAACGATCGAGTA
CGAATAA

Protein sequence :
MESILVLDFGGQYNQLISRRVREAHVFCEVKPCTIPLSEIKEGNYAGIIFTGGPASVYAKNAPTVDAGIFELGIPILGIC
YGAQLTAYLLGGNVASATTREYGKTSISTEESPIFKNVPRETTCWMSHTDYISEVPAGFVKVAHTSVCPVAAMANPAKKI
YAVQFHPEVMHTPEGMTMIKNFLYDVCGCKGTWHMSSFVEDQVLQLREKIGDKKVLCALSGGVDSSVAAVLINKAVGKQL
TCIFVDHGLLRKNEGNEVEEIFRNQFDINLIRVNVEDQFLGKLAGVSDPEKKRKIIGEEFIRVFEAEAKKIGTVDFLVQG
TIYPDVIESGPGAAAVIKSHHNVGGLPDNVDFKEIIEPLRILFKDEVRRAGLELGIPEKLVWRQPFPGPGLAIRVIGDIT
KEKLEIVRDADAIYREEIAKAGIDRDINQYFAALTNMRSVGVMGDERTYDYAVVLRAVTTTDFMTADWAQIPFAVLEKVS
SRIINEVRHVNRVLYDITSKPPATIEYE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-152 60
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 9e-153 60
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-153 60
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-130 51