Gene Information

Name : thyA (Mpe_A2051)
Accession : YP_001021244.1
Strain : Methylibium petroleiphilum PM1
Genome accession: NC_008825
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 2192971 - 2193822 bp
Length : 852 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGTCAGCTCTTCCTTCCCCCTCGCCCCGCCCCGCCCGCTCCCAGTACGAGGACTTCCTGCGCCACGTGCGCGACCACGG
TGTGGTCAAGGCCGACCGCACCGGCACCGGCACCACCAGCGTGTTCGGCCACCAGATGCGCTTCGACCTGCGCGAGGGCT
TTCCGCTGGTCACGACCAAGAAGGTCCATCTCAAGAGCATCGTCCTCGAACTGCTGTGGTTCCTGCGCGGCGACGGGAAC
GCCACCTGGCTGCAGGAACGCGGCGTGACGATCTGGGACGAGTGGGCCGCGCCCGACGGCGACCTCGGCCCGGTCTATGG
TGTGCAGTGGCGCAGTTGGCCCACGCCGGACGGCGGCCACGTCGACCAGATCGCCGAGGTGGTGAAGCAGCTCAAGACCA
ACCCTGATTCGCGGCGCATCATCGTCAGCGCGTGGAACGTGGCCGACTTGCCGAAGATGGCACTGATGCCCTGCCACGCC
TTCTTCCAGTTCTATGTGGCGCCCGGCGACTCGCCTTCGGCTCGGGGTCGGCTGTCGTGCCAGCTCTACCAGCGCAGCGC
CGACATCTTCCTCGGCGTGCCCTTCAACATCGCCAGCTACGCGCTGCTGACGCACATGCTGGCGCAGCAGTGCGACCTGG
AGGTGGGCGACTTCGTCTGGACCGGCGGCGACTGCCACATCTACAGCAACCACCGCGAGCAGGTCGAGCTGCAGCTCTCG
CGCGCGCCGCGCCCCTACCCCACGCTGCAGATCAAGCGCCGGCCGCCGTCGATCTTCGACTACGCCTACGAGGACTTCGA
GATCATCGGCTACGACCCGCACCCGGCCATCAAGGCGCCGGTCGCGGTCTGA

Protein sequence :
MSALPSPSPRPARSQYEDFLRHVRDHGVVKADRTGTGTTSVFGHQMRFDLREGFPLVTTKKVHLKSIVLELLWFLRGDGN
ATWLQERGVTIWDEWAAPDGDLGPVYGVQWRSWPTPDGGHVDQIAEVVKQLKTNPDSRRIIVSAWNVADLPKMALMPCHA
FFQFYVAPGDSPSARGRLSCQLYQRSADIFLGVPFNIASYALLTHMLAQQCDLEVGDFVWTGGDCHIYSNHREQVELQLS
RAPRPYPTLQIKRRPPSIFDYAYEDFEIIGYDPHPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 8e-91 68