Gene Information

Name : guaA (Mpe_A1622)
Accession : YP_001020819.1
Strain : Methylibium petroleiphilum PM1
Genome accession: NC_008825
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1749632 - 1751236 bp
Length : 1605 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCACGACAAGATCCTCATCCTCGACTTCGGTTCCCAGGTCACGCAGCTGATCGCAAGGCGCGTCCGCGAGGCGCATGT
GTACTGCGAGATCCACCCGAACGACGTGTCGGACGAGTTCATCCGCGAGTTCGCGCCGAAGGGCATCATCCTGTCGGGCA
GCCACGCCAGCACCTACGAGGACCACGACCTGCGCGCCCCGCAGGCGGTGTGGGAGCTGGGCGTGCCGGTGCTCGGCATC
TGCTACGGCATGTTCACGATGGTGGTCCAGCAGGGCGGCGAGGTTGAGGCCAGCGCGCACCGCGAGTTCGGCTACGCCGA
GGTGAGGGCGCATGGCCACACCCGGCTGCTGCAGGGCATCGAGGACTTCAGCACCCCTGAGGGCCATGGCATGCTGAAGG
TGTGGATGAGCCACGGCGACAAGGTCACCAAGCTGCCGCCCGGCTTTAAGCTGATGGCCAGCACGCCGAGCTGCCCGATC
GCCGGCATGGCCGACGAATCGCGCGGCTACTACGCGGTGCAGTTCCACCCCGAGGTCACGCACACGGTGCAGGGGCGCGC
GCTGCTGGAGCGCTTCGTGCTCGAGATCGCGAAGGCGCAGCCCGACTGGGTGATGAAGGATCATGTCGCCGAGGCGGTGG
CGGCGATCCGTGCGCAGGTGGGTGACGAGGAGGTGATCCTCGGCCTGTCGGGTGGCGTGGACTCCAGCGTGGCGGCGGCG
CTGATCCACCGCGCCATCGGCGACCGGCTGACCTGCGTGTTCGTCGATCACGGCCTGCTGCGCCTGAACGAAGGCGACAT
GGTGATGGAGATGTTCGCCGGCAAGCTGCACGCGAAGGTGGTCCGCGTCGATGCCGCCGAGCTGTTCATGAACGAGCTGG
CCGGCGTGGCCGACCCCGAGGCCAAGCGCAAGATCATCGGCCGGCTGTTCGTCGATGTCTTCAAGGCCGAGGCGGCCAAG
CTCAAGGCGAGCGGCGCGGGGCACCGCGGCGCGACCTTTCTGGCGCAGGGCACGATCTACCCGGACGTCATCGAGTCGGG
CGGTGCCAAGACCAAGAAGGCCACCACGATCAAGAGCCACCACAACGTCGGCGGCCTGCCCGAGCAGCTCGGCCTGAAGC
TGCTCGAGCCGCTGCGCGACCTGTTCAAGGACGAGGTGCGCGAGCTGGGCGTGGCCCTGGGCCTGCCGCACGACATGGTC
TACCGCCATCCCTTCCCGGGCCCTGGCCTGGGCGTGCGCATCCTCGGCGAGGTGAAGAAGGACTACGCCGACCTGCTGCG
CCGCGCCGACGCGATCTTCATCGAGGAGCTGCGCAACACCGTCGACCCGGCCTCCGGCAAGACCTGGTACGAGCTCACCA
GCCAGGCCTTCGCGGTCTTCCTGCCGGTCAAGAGCGTGGGCGTGATGGGAGACGGTCGCACCTACGACTACGTGGTCGCG
CTGCGCGCGGTGCAGACCAGCGACTTCATGACCGCCGACTGGGCCGAACTGCCCTATGCGCTGCTCAAGCGCACCTCGGG
CCGCATCATCAACGAGGTGCGCGGCATCAACCGCGTGACCTACGACGTGAGCAGCAAGCCGCCAGCGACGATCGAGTGGG
AATGA

Protein sequence :
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFIREFAPKGIILSGSHASTYEDHDLRAPQAVWELGVPVLGI
CYGMFTMVVQQGGEVEASAHREFGYAEVRAHGHTRLLQGIEDFSTPEGHGMLKVWMSHGDKVTKLPPGFKLMASTPSCPI
AGMADESRGYYAVQFHPEVTHTVQGRALLERFVLEIAKAQPDWVMKDHVAEAVAAIRAQVGDEEVILGLSGGVDSSVAAA
LIHRAIGDRLTCVFVDHGLLRLNEGDMVMEMFAGKLHAKVVRVDAAELFMNELAGVADPEAKRKIIGRLFVDVFKAEAAK
LKASGAGHRGATFLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPEQLGLKLLEPLRDLFKDEVRELGVALGLPHDMV
YRHPFPGPGLGVRILGEVKKDYADLLRRADAIFIEELRNTVDPASGKTWYELTSQAFAVFLPVKSVGVMGDGRTYDYVVA
LRAVQTSDFMTADWAELPYALLKRTSGRIINEVRGINRVTYDVSSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-117 50
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-117 50
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-117 50
guaA NP_938969.1 GMP synthase Not tested Not named Protein 8e-110 48