Gene Information

Name : guaA (P9303_00451)
Accession : YP_001016067.1
Strain : Prochlorococcus marinus MIT 9303
Genome accession: NC_008820
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 44874 - 46460 bp
Length : 1587 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTCCAATTCCCAGTCTGAAGGTCAGCGCCAGCCGGCAATCGTCATTCTCGATTTTGGCTCTCAGTATTCAGAGCTGAT
TGCCCGTCGGGTGCGAGAAACAGAGGTCTACTCATTGGTGATGAGCTATAGCACCTCAGCGGATGAGCTTCGCCAGCTTG
CCCCGAAGGGCATCATTTTGAGTGGCGGACCTAGCTCTGTGTATGCCGAGAGAGCGCCGCTGTGTGATCCGAACATTTGG
GATTTGGGTATTCCTGTGCTGGGGGTTTGTTATGGCATGCAATTGATGGTGCAGCAGTTGGGTGGTCGGGTGGAAATGGC
AACGGGCAAGGCCGAATACGGCAAGGCTCCTCTTGAAATTGATGACCCGACGGATCTGCTCACCAATGTTGAGAATGGAT
CCACCATGTGGATGAGCCATGGTGATTCAGTGCGCGCCTTACCTGAGGGGTTTGTGCGACTTGCTCATACAGCGAATACA
CCAGATGCGGCTGTGGCTTACCACACGCGTTCTCTTTATGGCGTGCAATTTCATCCTGAGGTGGTTCATTCCACTGATGG
AATGTCGTTGATTAGAAATTTTGTTTATCACATTTGTGGCTGTGAACCGGATTGGACTACGACCGCATTTATTGAAGAAG
CCGTTAGCCAGGTTCGTTCTCAAGTCGGAGATAAACGGGTGTTGCTTGCTTTGTCTGGTGGTGTTGATTCTTCCACTCTT
GCCTTTCTTTTAAAAAAGGCCATTGGAGATCAGCTCACGTGCATGTTTATTGATCAGGGGTTTATGCGTAAAGGTGAACC
TGAGTTTTTGATGGATTTCTTTGATCGTAAGTTCAATATTAATGTTGAATATATCAATGCAAGACAACGGTTTATTTCTA
AGTTGAATGGCATTGTTGATCCGGAAGAGAAACGTAAAATTATTGGTACCGAATTCATCAGGGTGTTTGAGGAGGAAAGC
AATCGTCTCGGTCCCTTTGATTATCTTGCGCAGGGCACTCTTTATCCGGATGTGATCGAGAGTGCTGGTACCAACATCGA
TCCGAAAACCGGAGAGCGGGTGGCGGTAAAGATCAAGAGCCACCACAATGTGGGCGGTCTTCCTAAAGATCTGCAGTTCA
AATTGGTGGAGCCGCTTAGGCGATTGTTTAAAGACGAGGTGCGAAAAGTAGGTCGTTCTTTGGGCTTGCCGGAAGAGATT
GTCCGCCGTCACCCTTTCCCTGGTCCAGGTCTGGCGATTCGCATTCTTGGTGAAGTGACCGACGAGAAGTTGAATTGTTT
GCGTGATGCCGATTTGATTGTTCGCGAAGAAATTCGTGAAGCTGGTTTGTATCACGAGATTTGGCAGGCTTTTGCCGTCT
TACTGCCGGTGCGCTCCGTCGGGGTAATGGGGGATCAGCGCACTTACGCTTGGCCGATTGTTTTGCGATGTGTCTCCAGT
GAGGACGGCATGACAGCGGATTGGTCGCGTTTACCTGATGAACTTTTGGAGCGTATCTCCAATCGAATTGTCAATGAAGT
GAGAGGTGTCAACCGTGTTGTGCTTGACATCACCAGCAAGCCTCCTGGAACGATTGAGTGGGAATAG

Protein sequence :
MSNSQSEGQRQPAIVILDFGSQYSELIARRVRETEVYSLVMSYSTSADELRQLAPKGIILSGGPSSVYAERAPLCDPNIW
DLGIPVLGVCYGMQLMVQQLGGRVEMATGKAEYGKAPLEIDDPTDLLTNVENGSTMWMSHGDSVRALPEGFVRLAHTANT
PDAAVAYHTRSLYGVQFHPEVVHSTDGMSLIRNFVYHICGCEPDWTTTAFIEEAVSQVRSQVGDKRVLLALSGGVDSSTL
AFLLKKAIGDQLTCMFIDQGFMRKGEPEFLMDFFDRKFNINVEYINARQRFISKLNGIVDPEEKRKIIGTEFIRVFEEES
NRLGPFDYLAQGTLYPDVIESAGTNIDPKTGERVAVKIKSHHNVGGLPKDLQFKLVEPLRRLFKDEVRKVGRSLGLPEEI
VRRHPFPGPGLAIRILGEVTDEKLNCLRDADLIVREEIREAGLYHEIWQAFAVLLPVRSVGVMGDQRTYAWPIVLRCVSS
EDGMTADWSRLPDELLERISNRIVNEVRGVNRVVLDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 3e-139 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-139 55
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-139 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 6e-134 53